Rutin
Research reviewed: Up until 03/2026
Rutin is a dietary supplement with 9 published peer-reviewed studies involving 346 participants, researched for Cardiovascular & Venous Health, Anti-inflammatory & Antioxidant, Metabolic Health and 1 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Cardiovascular & Venous Health
StrongAnti-inflammatory & Antioxidant
StrongMetabolic Health
StrongMetabolic Health & Inflammation
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Cardiovascular & Venous Health
To evaluate rutin on venous insufficiency and leg edema
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate rutin on venous insufficiency and leg edema
Dose
500 mg/day rutin
Participants
60 patients with chronic venous insufficiency
Duration
12 weeks
Results
Significant reduction in leg edema (p=0.01) and pain. CEAP venous disease classification improved. Capillary fragility and permeability reduced. Symptomatic venous insufficiency improved.
How They Measured It
Edema circumference, CEAP classification, pain VAS
To assess rutin on blood pressure and cardiovascular biomarkers
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To assess rutin on blood pressure and cardiovascular biomarkers
Dose
500 mg/day rutin
Participants
55 adults with prehypertension
Duration
8 weeks
Results
Significant reduction in SBP (-6 mmHg, p=0.02) and oxidised LDL (-15%). CRP reduced. HDL increased by 8%. Cardioprotective effects demonstrated.
How They Measured It
SBP, DBP, LDL, HDL, oxLDL, CRP
To evaluate rutin on anti-platelet and anti-thrombotic effects
Study Type
Randomised, controlled trial
Purpose
To evaluate rutin on anti-platelet and anti-thrombotic effects
Dose
250 mg/day rutin
Participants
40 adults at cardiovascular risk
Duration
4 weeks
Results
Significant reduction in platelet aggregation (p=0.02) and thromboxane B2. Fibrinogen levels reduced. Anti-thrombotic properties confirmed. Cardiovascular risk reduction demonstrated.
How They Measured It
Platelet aggregation, thromboxane B2, fibrinogen
Anti-inflammatory & Antioxidant
To evaluate rutin supplementation on antioxidant status and inflammation
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate rutin supplementation on antioxidant status and inflammation
Dose
500 mg/day rutin
Participants
46 healthy adults
Duration
8 weeks
Results
Significant increases in SOD (+18%) and GSH antioxidant enzyme activities. CRP reduced by 16%. TEAC antioxidant capacity increased. Well-tolerated.
How They Measured It
TEAC, SOD, GSH, CRP, IL-6
To assess rutin on inflammation in patients with type 2 diabetes
Study Type
Randomised, placebo-controlled
Purpose
To assess rutin on inflammation in patients with type 2 diabetes
Dose
500 mg/day rutin
Participants
50 type 2 diabetes patients
Duration
12 weeks
Results
Significant reduction in CRP (22%), IL-6 (19%), and TNF-alpha (14%) vs placebo. HbA1c trended lower. Oxidative stress markers reduced.
How They Measured It
CRP, IL-6, TNF-alpha, HbA1c
Metabolic Health
To evaluate rutin on lipid profile and insulin resistance
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate rutin on lipid profile and insulin resistance
Dose
500 mg/day rutin
Participants
50 overweight adults with dyslipidaemia
Duration
12 weeks
Results
Significant reductions in triglycerides (13%), LDL (9%), and HOMA-IR (-14%). HDL increased by 7%. Insulin sensitivity improved.
How They Measured It
LDL, HDL, triglycerides, HOMA-IR, fasting insulin
To assess rutin effects on bone health and osteoporosis prevention
Study Type
Randomised, controlled trial
Purpose
To assess rutin effects on bone health and osteoporosis prevention
Dose
100 mg/day rutin
Participants
45 postmenopausal women
Duration
6 months
Results
Significant reduction in bone resorption marker CTX (p=0.03). BMD trended toward maintenance vs loss in placebo. Calcium absorption markers improved.
How They Measured It
BMD, bone turnover markers (OC, CTX), calcium metabolism
To summarize clinical evidence for rutin supplementation benefits
Study Type
Systematic review
Purpose
To summarize clinical evidence for rutin supplementation benefits
Dose
Various
Participants
Systematic review
Duration
Various
Results
Evidence supports cardiovascular, anti-inflammatory, and metabolic benefits. Venous insufficiency benefit well-established. Antioxidant and anti-platelet effects consistent. Bone health preliminary. Generally well-tolerated.
How They Measured It
Systematic review of human trials
Metabolic Health & Inflammation
To evaluate the effects of a PEA-rutin and hydroxytyrosol food supplement in patients with metabolic syndrome.
Study Type
Randomized Controlled Trial
Purpose
To evaluate the effects of a PEA-rutin and hydroxytyrosol food supplement in patients with metabolic syndrome.
Dose
PEA co-micronized with rutin 700 mg/day plus hydroxytyrosol
Participants
Metabolic syndrome patients
Duration
3 months
Results
The PEA-rutin and hydroxytyrosol supplement significantly improved metabolic syndrome components including lipid profile, blood pressure, and waist circumference.
How They Measured It
Metabolic syndrome components (waist circumference, blood pressure, lipid profile, glucose)
Frequently Asked Questions
Common questions about Rutin research
There are currently 9 peer-reviewed studies on Rutin (Rutin), involving 346 total participants. Research covers Cardiovascular health, Anti-inflammatory, Antioxidant status and 2 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (8 human studies), and reported outcomes.
Rutin has been researched for: Cardiovascular health, Anti-inflammatory, Antioxidant status, Blood pressure, Venous health. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 8 out of 9 studies are human trials. Human trials carry more weight in our evidence scoring system.
Similar Supplements
Other supplements researched for similar health goals
