Fisetin
Research reviewed: Up until 03/2026
Fisetin is a dietary supplement with 8 published peer-reviewed studies involving 254 participants, researched for Senolytic & Anti-aging, Neuroprotection & Cognitive Function, Anti-inflammatory & Antioxidant and 1 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Senolytic & Anti-aging
ModerateNeuroprotection & Cognitive Function
ModerateAnti-inflammatory & Antioxidant
StrongMetabolic Health
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Senolytic & Anti-aging
To evaluate fisetin on senescence biomarkers and inflammation in older adults
Study Type
Randomised, double-blind, placebo-controlled pilot
Purpose
To evaluate fisetin on senescence biomarkers and inflammation in older adults
Dose
20 mg/kg/day fisetin for 2 consecutive days per month
Participants
40 adults aged 65-85
Duration
3 months
Results
Significant reduction in SASP factors including IL-6 and MMP-9 vs placebo. Physical function improved. First human senolytic trial for fisetin.
How They Measured It
Plasma SASP factors, p21, p16 in PBMCs, physical function
To assess fisetin safety and senolytic activity in diabetic kidney disease patients
Study Type
Open-label pilot study
Purpose
To assess fisetin safety and senolytic activity in diabetic kidney disease patients
Dose
20 mg/kg/day for 2 days
Participants
9 patients with diabetic kidney disease
Duration
Single 2-day treatment
Results
Significant reduction in multiple senescence markers in adipose tissue biopsies. Kidney function markers trended favorably. No serious adverse events.
How They Measured It
Senescence biomarkers in adipose tissue, kidney function
Neuroprotection & Cognitive Function
To evaluate fisetin supplementation on cognitive function in older adults with subjective cognitive decline
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate fisetin supplementation on cognitive function in older adults with subjective cognitive decline
Dose
100 mg/day fisetin
Participants
60 adults over age 60 with subjective cognitive decline
Duration
16 weeks
Results
Significant improvement in memory performance and attention vs placebo. MoCA scores improved by 1.8 points. Oxidative stress markers reduced.
How They Measured It
Cognitive battery, MoCA, memory performance, attention
To examine fisetin mechanisms for neuroprotection including SIRT1 activation
Study Type
In vitro and animal study (mechanistic)
Purpose
To examine fisetin mechanisms for neuroprotection including SIRT1 activation
Dose
Various concentrations
Participants
Cell and animal models
Duration
Various
Results
Fisetin activated SIRT1, reduced tau hyperphosphorylation, and protected against oxidative neuronal death. Synapse formation promoted in hippocampal neurons.
How They Measured It
Neuronal cell survival, SIRT1 activity, tau phosphorylation, oxidative stress
Anti-inflammatory & Antioxidant
To evaluate fisetin on inflammatory and oxidative stress markers in healthy adults
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate fisetin on inflammatory and oxidative stress markers in healthy adults
Dose
50 mg/day fisetin
Participants
35 healthy adults with mild inflammation
Duration
8 weeks
Results
Significant reduction in CRP (p=0.04), IL-6 (p=0.03) and oxidative stress markers. ORAC antioxidant capacity increased by 22%.
How They Measured It
CRP, IL-6, TNF-alpha, 8-OHdG, ORAC
To assess fisetin effects on inflammation in type 2 diabetes patients
Study Type
Randomised, controlled trial
Purpose
To assess fisetin effects on inflammation in type 2 diabetes patients
Dose
100 mg/day fisetin
Participants
50 type 2 diabetes patients
Duration
12 weeks
Results
Significant reductions in CRP (23%), IL-6 (18%), and TNF-alpha (15%). NF-kB pathway activity reduced.
How They Measured It
CRP, IL-6, TNF-alpha, HbA1c, fasting glucose
Metabolic Health
To evaluate fisetin on glucose regulation and insulin sensitivity
Study Type
Randomised, controlled trial
Purpose
To evaluate fisetin on glucose regulation and insulin sensitivity
Dose
100 mg/day fisetin
Participants
60 overweight adults with insulin resistance
Duration
12 weeks
Results
Significant improvement in HOMA-IR (p=0.02) and fasting insulin. Adiponectin increased. Lipid profile improved.
How They Measured It
FPG, HOMA-IR, insulin, adiponectin, lipids
To summarize the emerging clinical evidence for fisetin supplementation
Study Type
Systematic review
Purpose
To summarize the emerging clinical evidence for fisetin supplementation
Dose
Various
Participants
Systematic review
Duration
Various
Results
Emerging evidence for senolytic, anti-inflammatory, neuroprotective, and metabolic benefits. Multiple active mechanisms identified. Human evidence growing but early-stage.
How They Measured It
Systematic review of clinical and preclinical data
Frequently Asked Questions
Common questions about Fisetin research
There are currently 8 peer-reviewed studies on Fisetin (Fisetin), involving 254 total participants. Research covers Cellular health & senescence, Neuroprotection, Anti-inflammatory and 2 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (6 human studies), and reported outcomes.
Fisetin has been researched for: Cellular health & senescence, Neuroprotection, Anti-inflammatory, Antioxidant status, Longevity. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 6 out of 8 studies are human trials. Human trials carry more weight in our evidence scoring system.
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