CoQ10
Research reviewed: Up until 03/2026
CoQ10 is a dietary supplement with 13 published peer-reviewed studies involving 976 participants, researched for Cardiovascular Health, Migraine, Blood Sugar & Diabetes and 1 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Cardiovascular Health
StrongMigraine
StrongBlood Sugar & Diabetes
ModerateMale Fertility
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Cardiovascular Health
To evaluate the effects of CoQ10 supplementation, in addition to standard heart failure therapy on major adverse cardiovascular events and mortality (lifespan) in patients with moderate to severe chronic heart failure.
Study Type
Randomised, double-blind, placebo-controlled, multicentre trial
Purpose
To evaluate the effects of CoQ10 supplementation, in addition to standard heart failure therapy on major adverse cardiovascular events and mortality (lifespan) in patients with moderate to severe chronic heart failure.
Dose
300 mg/day CoQ10 (3 x 100 mg) or placebo
Participants
420 men and women with moderate to severe chronic heart failure, with an average age of 62 years
Duration
2 years
Results
The researchers observed that CoQ10 supplementation led to significantly fewer major adverse cardiovascular events at 2 years compared to placebo: 15% vs. 26%. All-cause mortality was also significantly lower: 10% vs. 18% (p = 0.018; hazard ratio 0.51), meaning the CoQ10 group had about a 49% lower risk of all-cause mortality compared to the control group over the study period. Cardiovascular mortality was likewise significantly reduced: 9% vs. 16%. Hospitalisations for worsening heart failure were significantly fewer in the CoQ10 group.
To investigate the effects of CoQ10 supplementation on cardiac function, cardiac stress markers, and exercise capacity and quality of life in heart failure patients.
Study Type
Randomised, double-blind, placebo-controlled trial
Purpose
To investigate the effects of CoQ10 supplementation on cardiac function, cardiac stress markers, and exercise capacity and quality of life in heart failure patients.
Dose
120 mg/day CoQ10 (2 x 60 mg) or placebo
Participants
120 men and women with heart failure with an average age of 67 years
Duration
6 months
Results
The study found that taking CoQ10 supplements daily for six months significantly improved several key health markers compared to a placebo group. Significant improvements in the CoQ10 group included a significant enhancement in the heart muscle's ability to contract and relax which indicates better heart pump function. Additionally, levels of NT-proBNP, a biomarker that indicates the severity of heart failure and cardiac stress, decreased significantly in the CoQ10 group (from 1401.9 pg/mL to 815.6 pg/mL) compared to the placebo group. Patients also experienced improved functional capacity, as shown by an increase in the 6-minute walk test distance (from 267 meters to 349.3 meters). Blood pressure also saw significant reductions in the CoQ10 group, with systolic blood pressure dropping from 135.8 mmHg to 124.2 mmHg and diastolic blood pressure from 80.3 mmHg to 74.2 mmHg. While Left Ventricular Ejection Fraction (LVEF), another measure of heart pumping ability, showed a slight but not statistically significant improvement in the CoQ10 group (from 38.9% to 40.6%), the overall findings suggest that CoQ10 can enhance cardiac function, reduce heart stress, and improve the quality of life for individuals with heart failure.
Evaluation of in vivo supplementation of 2660 mg D-aspartic acid and 200 mg ubiquinol and 10 mg zinc on different semen parameters in idiopathic male infertility: a randomized double blind placebo controlled study
Study Type
Randomised, double-blind, placebo-controlled
Purpose
Evaluation of in vivo supplementation of 2660 mg D-aspartic acid and 200 mg ubiquinol and 10 mg zinc on different semen parameters in idiopathic male infertility: a randomized double blind placebo controlled study
Dose
As per study protocol
Participants
See full study
Duration
See full study
Results
Statistically significant findings reported — see full study for complete results.
How They Measured It
See full study for endpoints and measurement methods
The effect of coenzyme Q10 pretreatment on ovarian reserve in women undergoing hysterectomy with bilateral salpingectomy: a randomised, double-blind, placebo-controlled trial
Study Type
Randomised, double-blind, placebo-controlled
Purpose
The effect of coenzyme Q10 pretreatment on ovarian reserve in women undergoing hysterectomy with bilateral salpingectomy: a randomised, double-blind, placebo-controlled trial
Dose
As per study protocol
Participants
See full study
Duration
See full study
Results
Statistically significant findings reported — see full study for complete results.
How They Measured It
See full study for endpoints and measurement methods
Effect of ubiquinol on electrophysiology during high-altitude acclimatization and de-acclimatization: A substudy of the Shigatse CARdiorespiratory fitness (SCARF) randomized clinical trial
Study Type
Randomised, double-blind, placebo-controlled
Purpose
Effect of ubiquinol on electrophysiology during high-altitude acclimatization and de-acclimatization: A substudy of the Shigatse CARdiorespiratory fitness (SCARF) randomized clinical trial
Dose
As per study protocol
Participants
See full study
Duration
See full study
Results
Statistically significant findings reported — see full study for complete results.
How They Measured It
See full study for endpoints and measurement methods
Effects of a mitochondrial-targeted ubiquinol on vascular function and exercise capacity in chronic kidney disease: a randomized controlled pilot study
Study Type
Randomised, double-blind, placebo-controlled
Purpose
Effects of a mitochondrial-targeted ubiquinol on vascular function and exercise capacity in chronic kidney disease: a randomized controlled pilot study
Dose
As per study protocol
Participants
See full study
Duration
See full study
Results
Statistically significant findings reported — see full study for complete results.
How They Measured It
See full study for endpoints and measurement methods
Clinical and biochemical assessment of the effect of topical use of coenzyme Q10 versus topical corticosteroid in management of symptomatic oral lichen planus: randomized controlled clinical trial
Study Type
Randomised, double-blind, placebo-controlled
Purpose
Clinical and biochemical assessment of the effect of topical use of coenzyme Q10 versus topical corticosteroid in management of symptomatic oral lichen planus: randomized controlled clinical trial
Dose
As per study protocol
Participants
See full study
Duration
See full study
Results
Statistically significant findings reported — see full study for complete results.
How They Measured It
See full study for endpoints and measurement methods
Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction
Study Type
Randomised, double-blind, placebo-controlled
Purpose
Effects of Ubiquinol and/or D-ribose in Patients With Heart Failure With Preserved Ejection Fraction
Dose
As per study protocol
Participants
See full study
Duration
See full study
Results
Statistically significant findings reported — see full study for complete results.
How They Measured It
See full study for endpoints and measurement methods
Migraine
To evaluate the effects of CoQ10 supplementation in reducing the frequency, severity, and duration of migraine attacks, on top of standard migraine prevention drugs, in women.
Study Type
Randomised, double-blind, placebo-controlled trial
Purpose
To evaluate the effects of CoQ10 supplementation in reducing the frequency, severity, and duration of migraine attacks, on top of standard migraine prevention drugs, in women.
Dose
400 mg/day CoQ10 or placebo alongside usual migraine preventive medication
Participants
84 women aged 18–50 years with episodic migraine (77 completed the study)
Duration
12 weeks
Results
The researchers observed that CoQ10 supplementation alongside usual migraine preventive medication significantly reduced migraine frequency (−56.7% vs. −41.9%), severity (−46.6% vs. −30.1%), and duration (−60.0% vs. −37.8%) compared to placebo. Quality of life scores also improved significantly in the CoQ10 group. No side effects were reported.
To study the effects of CoQ10 supplementation on migraine prevention, measuring attack frequency, headache days, and days with nausea in migraine patients.
Study Type
Randomised, double-blind, placebo-controlled trial
Purpose
To study the effects of CoQ10 supplementation on migraine prevention, measuring attack frequency, headache days, and days with nausea in migraine patients.
Dose
300 mg/day CoQ10 (3 x 100 mg) or placebo
Participants
42 adults with episodic migraine
Duration
3 months
Results
By the third treatment month, the researchers observed that CoQ10 supplementation was significantly superior to placebo for attack frequency, headache days, and days with nausea. The 50%-responder rate (the proportion of patients who achieved at least a 50% significant reduction in attack frequency) was 47.6% for CoQ10 versus only 14.4% for placebo, a nearly 3-fold difference.
Blood Sugar & Diabetes
To evaluate the effects of CoQ10 supplementation on blood sugar management and lipid profiles in patients with type 2 diabetes.
Study Type
Randomised, double-blind, placebo-controlled trial
Purpose
To evaluate the effects of CoQ10 supplementation on blood sugar management and lipid profiles in patients with type 2 diabetes.
Dose
150 mg/day CoQ10 or placebo
Participants
50 patients with type 2 diabetes mellitus; 40 completed the study
Duration
12 weeks
Results
After 12 weeks, the researchers observed that fasting plasma glucose (blood sugar levels after fasting overnight) was significantly lower in the CoQ10 group compared to placebo. HbA1c (a 2–3-month average of blood sugar levels) was also significantly lower in the CoQ10 group, indicating better blood sugar control. There were no significant changes in serum insulin or the insulin resistance index.
Male Fertility
To evaluate the effect of CoQ10 alone (monotherapy) and in combination with L-carnitine on sperm parameters and DNA fragmentation in infertile men with oligoasthenoteratozoospermia.
Study Type
Randomised, double-blind, placebo-controlled trial
Purpose
To evaluate the effect of CoQ10 alone (monotherapy) and in combination with L-carnitine on sperm parameters and DNA fragmentation in infertile men with oligoasthenoteratozoospermia.
Dose
200 mg/day CoQ10, or L-carnitine 1 g/day, or combination, or placebo
Participants
200 men with oligoasthenoteratozoospermia; 174 completed the study
Duration
3 months
Results
Compared to the placebo group, which showed no improvement, the CoQ10 monotherapy group demonstrated highly statistically significant improvements in all semen parameters including sperm count, motility, and morphology, as well as a significant reduction in sperm DNA fragmentation (the proportion of sperm with damaged DNA). Testosterone levels also increased significantly in the CoQ10 group, while luteinising hormone decreased, both suggesting improved testicular function. The combination of CoQ10 and L-carnitine produced superior results compared to either alone.
To assess the effects of CoQ10 in improving semen quality in men with idiopathic infertility.
Study Type
Randomised, double-blind, placebo-controlled trial
Purpose
To assess the effects of CoQ10 in improving semen quality in men with idiopathic infertility.
Dose
200 mg/day CoQ10 or placebo
Participants
60 infertile male patients (27-39 years of age)
Duration
6 months
Results
The researchers observed that CoQ10 levels in seminal plasma significantly increased significantly in the treatment group (from 61.29 to 99.39 ng/mL), as did CoQ10 in sperm cells. Both total sperm motility (from 33.14% to 39.41%) and progressive motility improved significantly. After a 6-month washout period (no supplementation), sperm parameters returned to near-baseline, supporting a cause-and-effect relationship.
Frequently Asked Questions
Common questions about CoQ10 research
There are currently 13 peer-reviewed studies on CoQ10 (CoQ10), involving 976 total participants. Research covers Cardiovascular Health, Migraine, Blood Sugar & Diabetes and 1 more areas. The overall evidence strength is rated as Very Strong.
The evidence is currently rated as "Very Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (13 human studies), and reported outcomes.
CoQ10 has been researched for: Cardiovascular Health, Migraine, Blood Sugar & Diabetes, Male Fertility. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 13 out of 13 studies are human trials. Human trials carry more weight in our evidence scoring system.
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