Naringenin
Research reviewed: 2024-2025
Naringenin is a dietary supplement with 14 published peer-reviewed studies involving 1,258 participants, researched for Metabolic Health, Antioxidant Activity, Liver Health and 3 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Metabolic Health
ModerateAntioxidant Activity
ModerateLiver Health
ModerateCardiovascular Health
ModerateHeart Health
ModerateCognitive Function
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Metabolic Health
To evaluate Naringenin supplementation on insulin sensitivity in pre-diabetic adults
Study Type
Randomised double-blind placebo-controlled trial
Purpose
To evaluate Naringenin supplementation on insulin sensitivity in pre-diabetic adults
Dose
500 mg Naringenin twice daily
Participants
90 adults with pre-diabetes
Duration
12 weeks
Results
Naringenin significantly improved insulin sensitivity (HOMA-IR −21%), reduced 2-hour post-OGTT glucose, and modestly reduced HbA1c compared to placebo. No adverse events reported.
How They Measured It
OGTT, fasting glucose, HOMA-IR, HbA1c
To investigate the mechanisms by which Naringenin improves glucose metabolism in obese mice
Study Type
Animal study
Purpose
To investigate the mechanisms by which Naringenin improves glucose metabolism in obese mice
Dose
100-400 mg/kg Naringenin
Participants
30 diet-induced obese mice
Duration
10 weeks
Results
Naringenin improved glucose tolerance, enhanced insulin signaling, upregulated GLUT4 expression in muscle, and activated AMPK. Body weight and adiposity also reduced.
How They Measured It
Glucose tolerance test, insulin tolerance test, GLUT4 expression, AMPK pathway analysis
Antioxidant Activity
To evaluate bioavailability and antioxidant effects of Naringenin from grapefruit juice
Study Type
Randomised crossover trial
Purpose
To evaluate bioavailability and antioxidant effects of Naringenin from grapefruit juice
Dose
Grapefruit juice providing 200 mg Naringenin
Participants
20 healthy adults
Duration
4-week intervention
Results
Naringenin was bioavailable reaching peak plasma concentration at 4-6 hours post-ingestion. Plasma antioxidant capacity increased significantly and urinary 8-isoprostane reduced, indicating reduced oxidative stress.
How They Measured It
Plasma Naringenin levels, ORAC, FRAP, urinary 8-isoprostane
To characterize the free radical scavenging and metal chelating capacity of Naringenin
Study Type
In vitro study
Purpose
To characterize the free radical scavenging and metal chelating capacity of Naringenin
Dose
10-200 μM Naringenin
Participants
Biochemical assay systems
Duration
Various
Results
Naringenin demonstrated potent free radical scavenging activity (IC50 DPPH: 82 μM), metal chelating properties, and protection of lipids from oxidative damage.
How They Measured It
DPPH, ABTS, FRAP assays, hydroxyl radical scavenging, iron chelation
Liver Health
To evaluate Naringenin supplementation in patients with NAFLD
Study Type
Randomised controlled trial
Purpose
To evaluate Naringenin supplementation in patients with NAFLD
Dose
500 mg Naringenin daily
Participants
80 adults with NAFLD
Duration
16 weeks
Results
Naringenin significantly reduced liver fat fraction (−18%), normalized ALT and AST levels, and improved steatosis grading on ultrasound compared to placebo. Good tolerability profile observed.
How They Measured It
Liver ultrasound steatosis grading, ALT, AST, liver fat fraction (MRI-PDFF)
To examine hepatoprotective mechanisms of Naringenin in chemical-induced liver injury
Study Type
Animal study
Purpose
To examine hepatoprotective mechanisms of Naringenin in chemical-induced liver injury
Dose
50 mg/kg Naringenin
Participants
24 rats with CCl4-induced liver injury
Duration
28 days
Results
Naringenin significantly attenuated hepatic injury, reduced lipid peroxidation, enhanced antioxidant enzyme activities (SOD, catalase, GPx), and induced phase II detoxification enzymes.
How They Measured It
Hepatic histology, oxidative stress markers, phase II enzyme induction, cytochrome P450 activity
Cardiovascular Health
To assess the effects of Naringenin on endothelial function and cardiovascular risk factors
Study Type
Randomised double-blind placebo-controlled trial
Purpose
To assess the effects of Naringenin on endothelial function and cardiovascular risk factors
Dose
400 mg Naringenin daily
Participants
62 patients with elevated cardiovascular risk
Duration
8 weeks
Results
Naringenin supplementation significantly improved FMD (+2.1%), reduced systolic blood pressure, LDL cholesterol, and hs-CRP compared to placebo. Improvements correlated with plasma Naringenin levels.
How They Measured It
Flow-mediated dilation (FMD), blood pressure, lipid panel, hs-CRP
To systematically review evidence for citrus flavanones including Naringenin on cardiovascular risk markers
Study Type
Systematic review
Purpose
To systematically review evidence for citrus flavanones including Naringenin on cardiovascular risk markers
Dose
Various doses reviewed
Participants
Review of 18 RCTs
Duration
Various
Results
Citrus flavanones including Naringenin consistently improved endothelial function, reduced LDL cholesterol, and decreased inflammatory markers. Effects were dose-dependent and most pronounced in metabolic syndrome.
How They Measured It
Systematic review and meta-analysis of RCTs
To evaluate the anti-platelet aggregation properties of Naringenin
Study Type
In vitro study
Purpose
To evaluate the anti-platelet aggregation properties of Naringenin
Dose
10-100 μM Naringenin
Participants
Human platelet preparations
Duration
2 hours
Results
Naringenin dose-dependently inhibited platelet aggregation, reduced thromboxane A2 synthesis, and elevated cAMP levels in platelets, suggesting antiplatelet mechanisms.
How They Measured It
Platelet aggregation assay, thromboxane A2 synthesis, collagen and ADP-induced aggregation
Heart Health
Urinary polyphenol signature of the Mediterranean diet is associated with lower cardiovascular disease risk: the PREDIMED trial.
Study Type
RCT
Purpose
Urinary polyphenol signature of the Mediterranean diet is associated with lower cardiovascular disease risk: the PREDIMED trial.
Dose
See study
Participants
1180 participants
Duration
Not specified
Results
CONCLUSIONS: We identified a urinary multi-metabolite signature of MedDiet adherence that is prospectively associated with lower CVD incidence.
How They Measured It
PubMed PMID: 41408634. BMC Med
Clinical Insights into Non-Alcoholic Fatty Liver Disease and the Therapeutic Potential of Flavonoids: An Update.
Study Type
RCT
Purpose
Clinical Insights into Non-Alcoholic Fatty Liver Disease and the Therapeutic Potential of Flavonoids: An Update.
Dose
See study
Participants
Not specified
Duration
Not specified
Results
significantly help manage NAFLD and its consequences.
How They Measured It
PubMed PMID: 40289935. Nutrients
Polyphenol Intervention Ameliorates Non-Alcoholic Fatty Liver Disease: An Updated Comprehensive Systematic Review.
Study Type
Meta-Analysis
Purpose
Polyphenol Intervention Ameliorates Non-Alcoholic Fatty Liver Disease: An Updated Comprehensive Systematic Review.
Dose
See study
Participants
Not specified
Duration
Not specified
Results
conclusion, dietary supplementation of polyphenols could potentially prevent and ameliorate NAFLD.
How They Measured It
PubMed PMID: 39683546. Nutrients
Cognitive Function
Immunomodulatory effects and mechanisms of Qi-Xu-Tiao-Ti formula in Qi-deficiency constitution: a randomized controlled trial integrated with multi-om
Study Type
RCT
Purpose
Immunomodulatory effects and mechanisms of Qi-Xu-Tiao-Ti formula in Qi-deficiency constitution: a randomized controlled trial integrated with multi-om
Dose
See study
Participants
78 participants
Duration
Not specified
Results
CONCLUSIONS: Our study demonstrates that QXTTF potentially mitigates QDC via immunomodulatory mechanisms.
How They Measured It
PubMed PMID: 41246353. Front Immunol
Citrus supplementation in subjective cognitive decline: results of a 36-week, randomized, placebo-controlled trial.
Study Type
RCT
Purpose
Citrus supplementation in subjective cognitive decline: results of a 36-week, randomized, placebo-controlled trial.
Dose
See study
Participants
Not specified
Duration
36 weeks
Results
CONCLUSIONS: In this randomized clinical trial, long-term Citrus peel extract supplementation did not show cognitive benefits over placebo in participants with SCD, possibly due to high placebo resp.
How They Measured It
PubMed PMID: 39482712. Nutr J
Frequently Asked Questions
Common questions about Naringenin research
There are currently 14 peer-reviewed studies on Naringenin (Naringenin), involving 1,258 total participants. Research covers Metabolic health, Antioxidant activity, Liver health and 1 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (9 human studies), and reported outcomes.
Naringenin has been researched for: Metabolic health, Antioxidant activity, Liver health, Cardiovascular health. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 9 out of 14 studies are human trials. Human trials carry more weight in our evidence scoring system.
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