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MgCl₂

Magnesium Chloride

Research reviewed: updated 08/24

Magnesium Chloride (MgCl₂) is a dietary supplement with 2 published peer-reviewed studies involving 277 participants, researched for General.

2
Studies
277
Participants
2009–2017
Research Span

Evidence at a Glance

Strength is scored by study design, sample size, study type, and outcomes

Overall: Moderate Evidence

General

Strong
2 studies 2 of 2 positive 277 participants

Research Visualised

Visual breakdown of the clinical data.

Study Quality Breakdown

What types of studies were conducted

2/2
Randomised
2/2
Double-Blind
2/2
Placebo-Controlled

Participants Per Study

Larger samples = more reliable results

Study 1 (2009)
79
Study 2 (2017)
198

Research Timeline

When the studies were published

1
2009
1
2017

All Studies

Detailed breakdown of each trial. Click to expand.

General

1

To investigate the effects of magnesium supplementation on blood pressure in diabetic hypertensive adults with low magnesium levels.

2009 79 participants 4 months 450 mg/day of magnesium, administered over a 4-month period.
Human Study RCT Double-Blind Placebo Positive

Study Type

Randomised, double-blinded, placebo-controlled clinical trial

Purpose

To investigate the effects of magnesium supplementation on blood pressure in diabetic hypertensive adults with low magnesium levels.

Dose

450 mg/day of magnesium, administered over a 4-month period.

Participants

79 male and female diabetic hypertensive patients with an average age of 60 years old

Duration

4 months

Results

The study found an association between magnesium supplementation and significantly reduced blood pressure in diabetic hypertensive adults with low blood magnesium levels, compared to placebo. Additionally, the researchers also observed significantly increased HDL (good) cholesterol levels following magnesium supplementation. The study also found that people with lower magnesium levels in their blood are 2.8 times more likely to have high blood pressure compared to those with normal magnesium levels. Overall, magnesium may be a useful treatment for lowering blood pressure, especially in people with low magnesium levels.

Read full study
2

To evaluate the effects of oral magnesium supplementation in individuals with metabolic syndrome and who have low levels of magnesium in the blood

2017 198 participants 16 weeks 382 mg/day of elemental magnesium (30 mL of magnesium chlori...
Human Study RCT Double-Blind Placebo Positive

Study Type

Randomised, double-blinded, placebo-controlled clinical trial

Purpose

To evaluate the effects of oral magnesium supplementation in individuals with metabolic syndrome and who have low levels of magnesium in the blood

Dose

382 mg/day of elemental magnesium (30 mL of magnesium chloride 5% solution) or a placebo solution

Participants

198 men and women with an average age of 40 years

Duration

16 weeks

Results

Researchers observed significant improvements in participants who received magnesium supplementation. These included a significant drop in systolic blood pressure (the top number) by 3.6 mmHg and diastolic blood pressure (the bottom number) by 5.5 mmHg compared to placebo. In addition, the researchers also observed a significant decrease in fasting blood sugar levels, significant reduction in triglyceride levels, and a significant increase in the amount of magnesium in the blood.

Read full study

Frequently Asked Questions

Common questions about Magnesium Chloride research

What does the research say about Magnesium Chloride?

There are currently 2 peer-reviewed studies on Magnesium Chloride (MgCl₂), involving 277 total participants. Research covers General. The overall evidence strength is rated as Moderate.

How strong is the evidence for Magnesium Chloride?

The evidence is currently rated as "Moderate Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (2 human studies), and reported outcomes.

What health goals has Magnesium Chloride been studied for?

Magnesium Chloride has been researched for: General. Each area has its own body of evidence which you can explore in the study breakdowns above.

Are the studies on Magnesium Chloride based on human trials?

Yes, 2 out of 2 studies are human trials. Human trials carry more weight in our evidence scoring system.