Magnesium Glycinate
Research reviewed: 2022-2022
Magnesium Glycinate (Magnesium Bisglycinate) is a dietary supplement with 8 published peer-reviewed studies involving 0 participants, researched for Sleep, Sleep Quality, Anxiety & Muscle Health and 1 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Sleep
ModerateSleep Quality
ModerateAnxiety & Muscle Health
ModerateHeart Health
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Sleep
To determine the effects of magnesium supplementation in individuals with major depressive disorder
Study Type
Case histories (Case #1)
Purpose
To determine the effects of magnesium supplementation in individuals with major depressive disorder
Dose
300 mg/d of magnesium as glycinate and later as taurinate Participant: A 59-year-old male with a history of mild depression, previously managed with antidepressants, suddenly developed severe anxiety, insomnia, muscle spasms, and suicidal depression after a year of intense stress and poor dietary habits.
Results
The subject reported that after the first night of starting magnesium, his sleep returned to near normal. Over the next four days, depression was significantly reduced for 4-6 hours after each dose, anxiety gradually faded, and headaches quickly disappeared. In the months that followed, normalcy was maintained only by frequent magnesium ingestion.
To determine the combined effect of vitamin D and magnesium glycinate supplementation on bone turnover markers and glycemic control
Study Type
Randomized, controlled clinical trial
Purpose
To determine the combined effect of vitamin D and magnesium glycinate supplementation on bone turnover markers and glycemic control
Dose
1000 IU Vitamin D3 + 360 mg Magnesium Glycinate daily
Participants
78 overweight and obese adults (both men and women)
Duration
12 weeks
Results
Combined supplementation did not significantly improve bone turnover markers or glycemic control compared to placebo
How They Measured It
Osteocalcin, bone turnover markers, fasting glucose, HbA1c
To investigate the effect of magnesium bisglycinate supplementation on sleep quality in adults reporting poor sleep
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To investigate the effect of magnesium bisglycinate supplementation on sleep quality in adults reporting poor sleep
Dose
350 mg magnesium bisglycinate/day
Participants
100 healthy adults with self-reported poor sleep quality
Duration
4 weeks
Results
Magnesium bisglycinate modestly improved insomnia severity scores vs placebo. Significant improvements seen in sleep onset latency and overall sleep quality on the ISI.
How They Measured It
Insomnia Severity Index (ISI), Pittsburgh Sleep Quality Index (PSQI)
To examine the clinical evidence for magnesium supplementation on sleep quality and anxiety in human subjects
Study Type
Systematic review of randomized controlled trials
Purpose
To examine the clinical evidence for magnesium supplementation on sleep quality and anxiety in human subjects
Dose
Various magnesium forms including glycinate/bisglycinate
Participants
Multiple RCTs reviewed
Duration
Various
Results
Magnesium supplementation associated with improvements in sleep quality and reductions in anxiety symptoms. Glycinate/bisglycinate forms showed good tolerability and bioavailability.
How They Measured It
PRISMA 2020 systematic review methodology; sleep and anxiety outcome measures
Sleep Quality
To evaluate magnesium bisglycinate on insomnia severity in adults with self-reported primary insomnia
Study Type
Randomized, placebo-controlled trial
Purpose
To evaluate magnesium bisglycinate on insomnia severity in adults with self-reported primary insomnia
Dose
250 mg elemental magnesium as magnesium bisglycinate, 1523 mg glycine
Participants
Adults with self-reported primary insomnia
Duration
28 days
Results
Magnesium bisglycinate resulted in 28% reduction in insomnia severity scores, significantly greater than 18% in placebo group.
How They Measured It
Insomnia severity scores (ISI), polysomnography
To examine effects of supplemental magnesium on self-reported anxiety and sleep quality
Study Type
Systematic review of randomized controlled trials
Purpose
To examine effects of supplemental magnesium on self-reported anxiety and sleep quality
Dose
Magnesium (various forms including glycinate)
Participants
Systematic review of multiple RCTs
Duration
Various study periods
Results
Magnesium supplementation, particularly glycinate forms, showed potential benefits for sleep quality and anxiety reduction.
How They Measured It
Sleep quality scores, anxiety measures
Anxiety & Muscle Health
To evaluate magnesium glycinate on muscle cramps, anxiety, and sleep in older adults
Study Type
Randomized trial
Purpose
To evaluate magnesium glycinate on muscle cramps, anxiety, and sleep in older adults
Dose
Magnesium glycinate supplement
Participants
Older adults with muscle cramps and sleep issues
Duration
8-12 weeks
Results
Magnesium glycinate reduced muscle cramps, improved anxiety symptoms, and enhanced sleep quality in older population.
How They Measured It
Muscle cramp frequency, anxiety scores, sleep quality
Heart Health
The effect of combined magnesium and vitamin D supplementation on vitamin D status, systemic inflammation, and blood pressure: A randomized double-bli
Study Type
RCT
Purpose
The effect of combined magnesium and vitamin D supplementation on vitamin D status, systemic inflammation, and blood pressure: A randomized double-bli
Dose
See study
Participants
Not specified
Duration
12 weeks
Results
CONCLUSIONS: A combined MagD treatment may be more effective in increasing serum 25OHD concentrations compared with VitD supplementation alone in Owt/Ob individuals.
How They Measured It
PubMed PMID: 35576873. Nutrition
Frequently Asked Questions
Common questions about Magnesium Glycinate research
There are currently 8 peer-reviewed studies on Magnesium Glycinate (Magnesium Bisglycinate), involving 0 total participants. Research covers Sleep. The overall evidence strength is rated as Moderate.
The evidence is currently rated as "Moderate Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (6 human studies), and reported outcomes.
Magnesium Glycinate has been researched for: Sleep. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 6 out of 8 studies are human trials. Human trials carry more weight in our evidence scoring system.
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