Magnesium Oxide
Research reviewed: 2024-2025
Magnesium Oxide (MgO) is a dietary supplement with 7 published peer-reviewed studies involving 7,085 participants, researched for General, Sleep, Constipation and 2 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
General
ModerateSleep
ModerateConstipation
ModerateAthletic Performance
ModeratePain Relief
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
General
To examine the effects of oral magnesium supplementation on blood pressure in patients with essential hypertension, a condition where a person has high blood pressure in their arteries without any specific identifiable cause.
Study Type
Single-arm non-blinded intervention study
Purpose
To examine the effects of oral magnesium supplementation on blood pressure in patients with essential hypertension, a condition where a person has high blood pressure in their arteries without any specific identifiable cause.
Dose
300 mg/day of oral magnesium-oxide supplementation
Participants
48 men and women with essential hypertension
Duration
1 month
Results
After taking magnesium supplements, both systolic (upper value of BP reading) and diastolic (lower value of BP reading) blood pressures significantly decreased. On average, systolic pressure significantly dropped from 139.7 to 130.8 mmHg, and diastolic pressure significantly decreased from 88.0 to 82.2 mmHg. Overall, results suggest that magnesium supplements may help lower blood pressure.
Sleep
To investigate the effect of magnesium supplementation on insomnia in elderly.
Study Type
Randomised, double-blind, placebo-controlled trial
Purpose
To investigate the effect of magnesium supplementation on insomnia in elderly.
Dose
500 mg/d elemental magnesium (2 x 250 mg tablets) or placebo
Participants
43 men and women with an average age of 65 years
Duration
8 weeks
Results
The researchers observed that participants who took magnesium supplements had significant improvements compared to the placebo group. These included significantly longer sleep time, better sleep efficiency, higher levels of serum renin and melatonin, and a significant decrease in insomnia severity, time to fall asleep, and stress levels. They also observed trends in reduced early morning awakenings and increased magnesium levels.
How They Measured It
Insomnia was assessed using the Insomnia Severity Index (ISI), a seven-item questionnaire measuring sleep difficulties and satisfaction. Participants also kept daily sleep logs to track their sleep time.
Constipation
Efficacy and safety of pharmacological therapies for functional constipation in children: a systematic review and meta-analysis.
Study Type
Meta-Analysis
Purpose
Efficacy and safety of pharmacological therapies for functional constipation in children: a systematic review and meta-analysis.
Dose
See study
Participants
7045 participants
Duration
2 weeks
Results
Study results available at linked source.
How They Measured It
PubMed PMID: 41101321. Lancet Child Adolesc Health
Dietary management of chronic constipation: a review of evidence-based strategies and clinical guidelines.
Study Type
Meta-Analysis
Purpose
Dietary management of chronic constipation: a review of evidence-based strategies and clinical guidelines.
Dose
See study
Participants
Not specified
Duration
Not specified
Results
demonstrated that psyllium supplements, specific probiotic supplements, magnesium oxide supplements, kiwifruits, prunes, rye bread and high mineral water content may be effective in the management o.
How They Measured It
PubMed PMID: 40888045. Proc Nutr Soc
Athletic Performance
British Dietetic Association Guidelines for the Dietary Management of Chronic Constipation in Adults.
Study Type
Meta-Analysis
Purpose
British Dietetic Association Guidelines for the Dietary Management of Chronic Constipation in Adults.
Dose
See study
Participants
Not specified
Duration
Not specified
Results
CONCLUSIONS: These are the first comprehensive evidence-based dietary guidelines for the management of constipation based upon a robust systematic review and GRADE processes.
How They Measured It
PubMed PMID: 41081513. J Hum Nutr Diet
British Dietetic Association Guidelines for the Dietary Management of Chronic Constipation in Adults.
Study Type
Meta-Analysis
Purpose
British Dietetic Association Guidelines for the Dietary Management of Chronic Constipation in Adults.
Dose
See study
Participants
Not specified
Duration
Not specified
Results
CONCLUSIONS: These are the first comprehensive evidence-based dietary guidelines for the management of constipation based upon a robust systematic review and GRADE processes.
How They Measured It
PubMed PMID: 41081381. Neurogastroenterol Motil
Pain Relief
Comparative Clinical Study on Magnesium Absorption and Side Effects After Oral Intake of Microencapsulated Magnesium (MAGSHAPE(TM) Microcapsules) Vers
Study Type
RCT
Purpose
Comparative Clinical Study on Magnesium Absorption and Side Effects After Oral Intake of Microencapsulated Magnesium (MAGSHAPE(TM) Microcapsules) Vers
Dose
See study
Participants
40 participants
Duration
7 days
Results
CONCLUSIONS: Altogether, this clinical study introduced MAGSHAPETM microcapsules as a bioavailable and well-tolerated alternative to existing Mg-based ingredients used in food supplements.
How They Measured It
PubMed PMID: 39770988. Nutrients
Frequently Asked Questions
Common questions about Magnesium Oxide research
There are currently 7 peer-reviewed studies on Magnesium Oxide (MgO), involving 7,085 total participants. Research covers General, Sleep. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (7 human studies), and reported outcomes.
Magnesium Oxide has been researched for: General, Sleep. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 7 out of 7 studies are human trials. Human trials carry more weight in our evidence scoring system.
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