Nobiletin
Research reviewed: 2022-2025
Nobiletin is a dietary supplement with 13 published peer-reviewed studies involving 2,126 participants, researched for Cognitive Function, Metabolic Health, Anti-cancer Activity and 3 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Cognitive Function
ModerateMetabolic Health
ModerateAnti-cancer Activity
WeakAnti-inflammatory Activity
ModerateMood & Mental Health
ModerateHeart Health
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Cognitive Function
To evaluate Nobiletin on cognitive deficits in a senescence-accelerated mouse model
Study Type
Animal study
Purpose
To evaluate Nobiletin on cognitive deficits in a senescence-accelerated mouse model
Dose
10-30 mg/kg Nobiletin
Participants
30 SAMP8 mice
Duration
8 weeks
Results
Nobiletin significantly improved spatial memory and object recognition, increased dendritic spine density in hippocampus, elevated BDNF expression, and reduced amyloid burden in aged mice.
How They Measured It
Morris water maze, object recognition test, dendritic spine density, BDNF expression
To evaluate safety and cognitive effects of Nobiletin in older adults with mild cognitive impairment
Study Type
Pilot randomised controlled trial
Purpose
To evaluate safety and cognitive effects of Nobiletin in older adults with mild cognitive impairment
Dose
60 mg Nobiletin daily
Participants
60 older adults with MCI
Duration
16 weeks
Results
Nobiletin showed good tolerability and bioavailability. Significant improvement in verbal memory and MMSE scores compared to placebo at 16 weeks.
How They Measured It
MMSE, MoCA, verbal memory tests, plasma Nobiletin levels
Perilla seed oil in combination with nobiletin-rich ponkan powder enhances cognitive function in healthy elderly Japanese individuals: a possible supp
Study Type
RCT
Purpose
Perilla seed oil in combination with nobiletin-rich ponkan powder enhances cognitive function in healthy elderly Japanese individuals: a possible supp
Dose
See study
Participants
49 participants
Duration
12 months
Results
significantly higher cognitive index scores than the PO group.
How They Measured It
PubMed PMID: 35171190. Food Funct
Metabolic Health
To investigate anti-obesity and metabolic effects of Nobiletin in high-fat-fed mice
Study Type
Animal study
Purpose
To investigate anti-obesity and metabolic effects of Nobiletin in high-fat-fed mice
Dose
50-200 mg/kg Nobiletin
Participants
24 HFD-fed mice
Duration
12 weeks
Results
Nobiletin significantly reduced weight gain, adiposity, and hepatic fat accumulation. Improved glucose tolerance and insulin sensitivity, upregulated mitochondrial biogenesis genes, and activated AMPK pathway.
How They Measured It
Body weight, adipose tissue mass, glucose tolerance, lipid profile, gene expression
To evaluate the metabolic effects of Nobiletin in adults with metabolic syndrome
Study Type
Randomised controlled trial
Purpose
To evaluate the metabolic effects of Nobiletin in adults with metabolic syndrome
Dose
100 mg Nobiletin twice daily
Participants
80 adults with metabolic syndrome
Duration
12 weeks
Results
Nobiletin significantly improved fasting glucose (−9%), triglycerides (−14%), and waist circumference. HDL cholesterol increased. Adiponectin elevated and resistin reduced compared to placebo group.
How They Measured It
Fasting glucose, insulin, HbA1c, lipid panel, adipokines, waist circumference
Anti-cancer Activity
To characterize the anti-proliferative mechanisms of Nobiletin in colorectal cancer cells
Study Type
In vitro study
Purpose
To characterize the anti-proliferative mechanisms of Nobiletin in colorectal cancer cells
Dose
20-200 μM Nobiletin
Participants
HCT-116 and HT-29 colorectal cancer cell lines
Duration
72 hours
Results
Nobiletin potently inhibited colorectal cancer cell proliferation (IC50 ~60 μM), induced apoptosis, suppressed Wnt/β-catenin signaling, and reduced invasive capacity in Matrigel invasion assays.
How They Measured It
Cell viability, apoptosis, Wnt/β-catenin signaling, cell cycle analysis, invasion assays
Anti-inflammatory Activity
To characterize anti-neuroinflammatory effects of Nobiletin in glial cells and brain
Study Type
In vitro and animal study
Purpose
To characterize anti-neuroinflammatory effects of Nobiletin in glial cells and brain
Dose
10-100 μM (in vitro), 20 mg/kg (animal)
Participants
BV-2 microglial cells and 20 mice with LPS-induced neuroinflammation
Duration
24 hours (in vitro), 7 days (animal)
Results
Nobiletin potently suppressed microglial activation, reduced TNF-α, IL-6, iNOS, and NO production. In vivo experiments confirmed reduced neuroinflammation and improved behavioral outcomes in LPS-treated mice.
How They Measured It
Microglial activation markers (Iba-1), pro-inflammatory cytokines, NO production, NF-κB activation
To comprehensively review biological activities and molecular mechanisms of Nobiletin
Study Type
Systematic review
Purpose
To comprehensively review biological activities and molecular mechanisms of Nobiletin
Dose
Various
Participants
Review of 60+ studies
Duration
Various
Results
Nobiletin demonstrates wide-ranging biological activities including anti-inflammatory, anti-tumor, neuroprotective, and metabolic regulatory effects. Multiple signaling pathways (NF-κB, Wnt, AMPK, MAPK) are targeted.
How They Measured It
Systematic review of in vitro, in vivo, and clinical studies
To evaluate the anti-inflammatory effects of Nobiletin in subjects with elevated CRP
Study Type
Randomised controlled trial
Purpose
To evaluate the anti-inflammatory effects of Nobiletin in subjects with elevated CRP
Dose
100 mg Nobiletin daily
Participants
60 adults with elevated baseline CRP
Duration
8 weeks
Results
Nobiletin significantly reduced hs-CRP (−24%), IL-6, and TNF-α compared to placebo. NF-κB activity in peripheral blood mononuclear cells also significantly suppressed.
How They Measured It
hs-CRP, IL-6, TNF-α, fibrinogen, NF-κB in PBMCs
Mood & Mental Health
Effects of a flavonoid-enriched orange juice on antioxidant capacity, lipid profile, and inflammation in obese patients: A randomized placebo-controll
Study Type
RCT
Purpose
Effects of a flavonoid-enriched orange juice on antioxidant capacity, lipid profile, and inflammation in obese patients: A randomized placebo-controll
Dose
See study
Participants
22 participants
Duration
Not specified
Results
Study results available at linked source.
How They Measured It
PubMed PMID: 40597485. Food Res Int
Exploration of the mechanism of Traditional Chinese Medicine for anxiety and depression in patients with diarrheal irritable bowel syndrome based on n
Study Type
Meta-Analysis
Purpose
Exploration of the mechanism of Traditional Chinese Medicine for anxiety and depression in patients with diarrheal irritable bowel syndrome based on n
Dose
See study
Participants
2055 participants
Duration
Not specified
Results
CONCLUSION: Chinese Herbal Medicine (CHM) offers a promising and safe treatment approach for patients dealing with Diarrheal Irritable Bowel Syndrome (IBS-D) accompanied by anxiety and depression; t.
How They Measured It
PubMed PMID: 38835657. Front Pharmacol
Evidence and Characteristics of Traditional Chinese Medicine for Coronary Heart Disease Patients With Anxiety or Depression: A Meta-Analysis and Syste
Study Type
Meta-Analysis
Purpose
Evidence and Characteristics of Traditional Chinese Medicine for Coronary Heart Disease Patients With Anxiety or Depression: A Meta-Analysis and Syste
Dose
See study
Participants
Not specified
Duration
Not specified
Results
Conclusion: CHM exhibited an obvious efficacy in treating CHD patients with anxiety or depression, especially for improving the symptom of angina pectoris.
How They Measured It
PubMed PMID: 35600859. Front Pharmacol
Heart Health
Combining single-cell RNA sequencing and network pharmacology to explore the target of cangfu daotan decoction in the treatment of obese polycystic ov
Study Type
RCT
Purpose
Combining single-cell RNA sequencing and network pharmacology to explore the target of cangfu daotan decoction in the treatment of obese polycystic ov
Dose
See study
Participants
Not specified
Duration
Not specified
Results
CONCLUSION: CFDT can improve the immune microenvironment of patients to some extent, reduce their economic burden, and enhance IVF outcomes.
How They Measured It
PubMed PMID: 39539629. Front Pharmacol
Frequently Asked Questions
Common questions about Nobiletin research
There are currently 13 peer-reviewed studies on Nobiletin (Nobiletin), involving 2,126 total participants. Research covers Cognitive function, Metabolic health, Anti-cancer activity and 1 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (8 human studies), and reported outcomes.
Nobiletin has been researched for: Cognitive function, Metabolic health, Anti-cancer activity, Anti-inflammatory activity. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 8 out of 13 studies are human trials. Human trials carry more weight in our evidence scoring system.
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