NMN
Research reviewed: up until 02/2023
NMN (Nicotinamide Mononucleotide) is a dietary supplement with 22 published peer-reviewed studies involving 471 participants, researched for Anti-ageing, NAD+ Levels, Diabetes and 3 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Anti-ageing
ModerateNAD+ Levels
ModerateDiabetes
ModerateAlzheimer's disease
WeakExercise performance
StrongSafety
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Anti-ageing
To evaluate whether chronic NMN supplementation elevates blood NAD+ levels and affects physiological dysfunctions in healthy older participants. NAD+ is a critical molecule that supports energy production, DNA repair, and cellular communication. NMN dose: 250 mg/day or a placebo
Study Type
Randomised, double-blind, placebo-controlled, parallel-group trial
Purpose
To evaluate whether chronic NMN supplementation elevates blood NAD+ levels and affects physiological dysfunctions in healthy older participants. NAD+ is a critical molecule that supports energy production, DNA repair, and cellular communication. NMN dose: 250 mg/day or a placebo
Participants
42 men aged over 65 years
Duration
6 or 12 weeks
Results
Long-term NMN supplementation was well tolerated and caused no significant adverse effects. Blood analyses revealed significant increases in NAD+ and its related metabolites concentrations, which play crucial roles in processes associated with energy production and tissue repair Research has found that NAD+ levels naturally decline with age, and an increase in NAD+ may enhance energy metabolism, support cell and tissue repair, and contribute to overall well-being. The researchers observed significant improvements in muscle performance like grip strength and walking speed. It is worth noting that reductions in strength are a clinical indicator of ageing. The authors concluded that long-term NMN supplementation may be used to boost NAD+ for preventing age-related muscle dysfunctions in humans.
To investigate the long-term effects of NMN administration on age-associated physiological decline in mice. Age-related complication: Age-associated physiological decline NMN dose: 100 and 300 mg/kg for 12 months
Study Type
Animal study (mice)
Purpose
To investigate the long-term effects of NMN administration on age-associated physiological decline in mice. Age-related complication: Age-associated physiological decline NMN dose: 100 and 300 mg/kg for 12 months
Duration
12 months
Results
The study found that orally administered NMN was quickly absorbed, efficiently transported into blood circulation, and immediately converted to NAD+ in major metabolic tissues (tissues are groups of similar cells that work together to perform a specific function in the body). NAD+ is a crucial coenzyme involved in various cellular processes, including energy production, DNA repair, and cell signalling. In addition, the study found that NMN suppressed age-associated body weight gain and enhanced energy metabolism, improved insulin sensitivity, eye function, and other features with no toxic effects. NMN also prevented age-associated gene expression changes. This means that NMN may have the ability to counteract or prevent the alterations in gene activity that typically occur as a result of ageing. These effects indicate that NMN (and other NAD+ intermediates) may be an effective anti-ageing intervention in humans, although clinical studies are required.
To investigate the effects of NMN supplementation on blood vessel dysfunction (a condition where the inner lining of blood vessels does not function properly) and oxidative stress (an imbalance between harmful molecules called free radicals and antioxidants in the body), which are both associated with ageing and contribute to an increased risk of cardiovascular diseases, impaired cellular function, chronic inflammation, and accelerated ageing. Age-related complication: Age-associated vascular dysfunction and oxidative stress NMN dose: 300 mg/kg body weight/day in drinking water or a control (just drinking water)
Study Type
Animal study (aged mice)
Purpose
To investigate the effects of NMN supplementation on blood vessel dysfunction (a condition where the inner lining of blood vessels does not function properly) and oxidative stress (an imbalance between harmful molecules called free radicals and antioxidants in the body), which are both associated with ageing and contribute to an increased risk of cardiovascular diseases, impaired cellular function, chronic inflammation, and accelerated ageing. Age-related complication: Age-associated vascular dysfunction and oxidative stress NMN dose: 300 mg/kg body weight/day in drinking water or a control (just drinking water)
Duration
8 weeks
Results
8 weeks of NMN supplementation restored a marker of arterial sirtuin activity. Sirtuins are proteins that are known to have protective effects on blood vessels and promote healthy ageing. NMN also improved age-associated blood vessel dysfunction and artery stiffening. Artery stiffening refers to the loss of flexibility and increased rigidity of blood vessel walls, which can lead to reduced blood flow, elevated blood pressure, and an increased risk of cardiovascular diseases. These improvements were associated with restored nitric oxide, a molecule that plays a crucial role in regulating blood vessel function, as well as the either complete or partial normalisation of structural proteins in the arterial wall and a reduction of vascular oxidative stress, which is important for maintaining the health and function of blood vessels and reducing the risk of related diseases. The results provide evidence that oral supplementation with NMN may restore SIRT1 activity (a sirtuin gene) and potentially combat or reverse age-related arterial dysfunction by decreasing oxidative stress.
Animal study (aged mice) Age-related complication: Age-associated decline in DNA repair NMN dose: 500 mg/kg body weight/day
Study Type
Animal study (aged mice) Age-related complication: Age-associated decline in DNA repair NMN dose: 500 mg/kg body weight/day
Duration
7 days
Results
NMN treatment reduced DNA damage and protected against changes in haemoglobin, a protein found in red blood cells that plays a crucial role in transporting oxygen from the lungs to the body's tissues and organs. NMN also protected against changes in white blood cell count (including lymphocytes). Reducing DNA damage and maintaining stable haemoglobin and white blood cell levels contribute to better cellular health, improved oxygen transport, and a well-functioning immune system. These factors collectively support overall health and reduce the risk of various age-related diseases and health complications.
To compare NMN with nicotinamide (vitamin B3) as a superior precursor of NAD in mice. NAD plays a vital role in supporting mitochondrial function for cellular energy production, but its levels decrease with age, affecting energy production, DNA repair, and essential processes. Maintaining healthy NAD levels may help mitigate some of the effects of ageing. NMN dose: 45 μmol//kg body weight injected intraperitoneally (single dose)
Study Type
Animal study (rats)
Purpose
To compare NMN with nicotinamide (vitamin B3) as a superior precursor of NAD in mice. NAD plays a vital role in supporting mitochondrial function for cellular energy production, but its levels decrease with age, affecting energy production, DNA repair, and essential processes. Maintaining healthy NAD levels may help mitigate some of the effects of ageing. NMN dose: 45 μmol//kg body weight injected intraperitoneally (single dose)
Results
Compared to nicotinamide, NMN resulted in a higher increase in NAD+, activated a higher response of SIRT1 (a sirtuin gene linked to healthy ageing) and had greater anti-aging activity.These findings may indicate enhanced energy production, improved DNA repair, better cellular health, and potentially slowing down of the ageing process.
In mice supplemented with NMN, researchers assessed the role of NAD+ (a critical molecule for cellular functions) and SIRT1 (a protein known as a sirtuin, which is involved in regulating cellular processes related to ageing and relies on NAD for its activity) in acute kidney injury susceptibility. NMN is known as the building block for NAD. Age-related complication: Age-associated susceptibility to acute kidney injury NMN dose: 500 mg/kg body weight/day (intraperitoneal)
Study Type
Animal study (aged mice)
Purpose
In mice supplemented with NMN, researchers assessed the role of NAD+ (a critical molecule for cellular functions) and SIRT1 (a protein known as a sirtuin, which is involved in regulating cellular processes related to ageing and relies on NAD for its activity) in acute kidney injury susceptibility. NMN is known as the building block for NAD. Age-related complication: Age-associated susceptibility to acute kidney injury NMN dose: 500 mg/kg body weight/day (intraperitoneal)
Duration
4 days
Results
NMN supplementation increased NAD+ levels (an important molecule for energy production, DNA repair, and cell signalling) in aged kidneys. This increase in NAD+ levels was also associated with increased activity of SIRT1 (a protective protein), and protected aged kidneys from both ischemia–reperfusion (reduced blood flow) and chemotherapy-related kidney injuries.
To explore the potential of NMN in restoring capillary density and improving endurance in old mice. Capillaries are the smallest blood vessels in the body. Capillary density is important for the exchange of oxygen, nutrients, and waste products between the blood and tissues. Age-related complication: Blood vessel ageing NMN dose: 400 mg/kg body weight/day (in drinking water)
Study Type
Animal study (aged mice)
Purpose
To explore the potential of NMN in restoring capillary density and improving endurance in old mice. Capillaries are the smallest blood vessels in the body. Capillary density is important for the exchange of oxygen, nutrients, and waste products between the blood and tissues. Age-related complication: Blood vessel ageing NMN dose: 400 mg/kg body weight/day (in drinking water)
Duration
2 months
Results
NMN improved blood flow by restoring the capillary density (the number of tiny blood vessels) of elderly mice to youthful levels. Capillary density is important for various physiological processes, including tissue growth, repair, and metabolism. NMN also improved the treadmill endurance of old mice towards youthful levels.
NAD+ Levels
The primary objective was to evaluate blood concentrations of nicotinamide adenine dinucleotide (NAD) with different doses of NMN. NAD is a vital molecule that acts like a helper in the body's cells, participating in important processes like turning food into energy and helping to repair damaged DNA. The secondary objectives were to assess the safety, tolerability and clinical efficacy of NMN supplementation. Measurement methods: Clinical efficacy was evaluated by conducting a subjective general health assessment (survey) and measuring NAD blood concentration, physical performance (six-minute walking test), blood biological age (Aging.Ai 3.0 calculator) and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). The HOMA-IR calculation involves analysing fasting blood glucose and insulin levels to provide an estimate of insulin resistance. NMN dose: 300, 600 or 900 mg/day, or a placebo
Study Type
Randomised, multicentre, double-blind, placebo-controlled, parallel group, dose-dependent trial
Purpose
The primary objective was to evaluate blood concentrations of nicotinamide adenine dinucleotide (NAD) with different doses of NMN. NAD is a vital molecule that acts like a helper in the body's cells, participating in important processes like turning food into energy and helping to repair damaged DNA. The secondary objectives were to assess the safety, tolerability and clinical efficacy of NMN supplementation. Measurement methods: Clinical efficacy was evaluated by conducting a subjective general health assessment (survey) and measuring NAD blood concentration, physical performance (six-minute walking test), blood biological age (Aging.Ai 3.0 calculator) and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). The HOMA-IR calculation involves analysing fasting blood glucose and insulin levels to provide an estimate of insulin resistance. NMN dose: 300, 600 or 900 mg/day, or a placebo
Participants
80 middle-aged healthy adults
Duration
60 days
Results
Compared to the placebo, the blood concentration of NAD significantly improved as the NMN dose increased (dose-dependent). An increase in NAD+ may enhance energy metabolism, support cell and tissue repair, and contribute to overall well-being. Research has found that NAD+ levels naturally decline with age. The most beneficial effects in the study, particularly on blood NAD levels and physical performance, were achieved with a daily oral intake of 600 mg. Oral administration of NMN up to 900 mg/day for 60 days was safe and well tolerated. The 900 mg/day oral dose did not have significantly better efficacy than the 600 mg/day dose. In addition, the study found an association between NMN supplementation and improvements in physical endurance and general health conditions, as evidenced by significant improvements in measures such as the six-minute walking test, blood biological age, and general health survey when compared to a placebo. Overall, these findings suggest that NMN supplementation may improve health and physical performance.
To investigate the influence of 12-week NMN supplementation on biochemical and metabolic health parameters. NMN dose: 250 mg/day (2 x 125 mg/day) or a placebo
Study Type
Randomised, double-blind, placebo-controlled, parallel-group trial
Purpose
To investigate the influence of 12-week NMN supplementation on biochemical and metabolic health parameters. NMN dose: 250 mg/day (2 x 125 mg/day) or a placebo
Participants
36 healthy, middle-aged men and women
Duration
12 weeks
Results
The researchers observed that serum nicotinamide (NAD+) levels were significantly higher in the NMN intake group than in the placebo group. Nicotinamide is a form of vitamin B3 and a building block for NAD+, which plays a critical role in cellular energy production and other cellular processes. Low levels of nicotinamide in the blood may indicate a vitamin B3 deficiency, potentially impacting various aspects of health, as NAD+ is involved in many vital processes within the cells. NMN supplementation showed potential in reducing arterial stiffness as indicated by a tendency of pulse wave velocity values, a measure of arterial stiffness, to decrease in the NMN group. Stiff arteries hinder blood flow, which can increase the risk of heart-related problems. However, no significant difference was found between the NMN and placebo groups. Long-term NMN supplementation at 250 mg/day was well tolerated and did not cause adverse events. NMN safely and effectively elevated NAD+ metabolism in healthy middle-aged adults.
Diabetes
To investigate the effect of NMN supplementation on metabolic function in postmenopausal women with prediabetes who are overweight or obese NMN dose: 250 mg/day or placebo
Study Type
Randomised double-blind placebo-controlled trial
Purpose
To investigate the effect of NMN supplementation on metabolic function in postmenopausal women with prediabetes who are overweight or obese NMN dose: 250 mg/day or placebo
Participants
25 postmenopausal women with prediabetes
Duration
10 weeks
Results
The study found an association between NMN supplementation and increased muscle insulin signalling, which involves the phosphorylation (activation) of certain proteins such as protein kinase AKT and the targeting of rapamycin (mTOR), compared to the placebo group. These proteins work together and are crucial for maintaining proper blood sugar levels and ensuring the muscles have the energy they need to function effectively. In addition, NMN supplementation was associated with increased muscle insulin sensitivity, indicating that the muscles became more responsive to the effects of insulin, a crucial factor for managing blood sugar levels and overall metabolic well-being. This improvement was measured by how quickly glucose was removed per unit of fat-free mass.
To investigate whether NMN could help treat diabetes caused by diet and ageing in mice. Age-related complication: Age- and diet-induced diabetes NMN dose: 500 mg/kg body weight/day intraperitoneally for 7–10 days
Study Type
Animal study (age-induced and diet-induced diabetic mice)
Purpose
To investigate whether NMN could help treat diabetes caused by diet and ageing in mice. Age-related complication: Age- and diet-induced diabetes NMN dose: 500 mg/kg body weight/day intraperitoneally for 7–10 days
Results
Researchers observed several positive effects of NMN in mice with type 2 diabetes. Firstly, NMN improved glucose and lipid metabolism, specifically enhancing insulin secretion, insulin sensitivity, lipid profile, hepatic insulin sensitivity, and glucose tolerance. Improvements in these factors collectively contribute to maintaining healthy blood sugar levels, efficient energy metabolism, and overall cardiovascular health. When these aspects are functioning optimally, the risk of chronic diseases such as type 2 diabetes and cardiovascular diseases is lowered. Secondly, NMN restored NAD+ levels (a molecule involved in energy metabolism) in the liver and body fat. Elevated NAD+ levels are generally associated with improved cellular health, enhanced metabolism, and potential benefits for longevity and overall well-being. Thirdly, NMN normalised the inflammatory response, circadian rhythm (the body's internal clock that regulates sleep and other functions) and oxidative stress (cell damage caused by harmful molecules) affected by high-fat diets and ageing. These improvements were partly attributed to increased NAD+ levels and the activation of SIRT1, a protein associated with metabolic regulation and longevity. The results provide evidence that promoting NAD+ biosynthesis by administering NMN may be an effective intervention to treat the pathophysiology of diet- and age-induced type 2 diabetes.
To study the impact of NMN on beta-amyloid oligomer-induced neuronal death and cognitive impairment. These oligomers are considered to be toxic and are thought to play a significant role in the development and progression of Alzheimer's disease. Age-related complication:
Study Type
Animal (rats) and cellular study
Purpose
To study the impact of NMN on beta-amyloid oligomer-induced neuronal death and cognitive impairment. These oligomers are considered to be toxic and are thought to play a significant role in the development and progression of Alzheimer's disease. Age-related complication:
Alzheimer's disease
To investigate the effect of NMN on brain mitochondrial impairments. Mitochondria are the energy-producing "powerhouses" of our cells. Age-related complication under study: Alzheimer’s disease NMN dose: 100 mg/kg body weight subcutaneously every other day for 28 days
Study Type
Animal study (a mice model of Alzheimer’s disease)
Purpose
To investigate the effect of NMN on brain mitochondrial impairments. Mitochondria are the energy-producing "powerhouses" of our cells. Age-related complication under study: Alzheimer’s disease NMN dose: 100 mg/kg body weight subcutaneously every other day for 28 days
Duration
28 days
Results
Researchers observed improvements in the functioning of mitochondria, the energy-producing “powerhouses” of cells. In Alzheimer’s disease, there are known issues with the functioning of mitochondria. There was also a reduction in mutant amyloid precursor proteins, which may potentially slow down or prevent the progression of Alzheimer's disease. NMN treatment also increased the levels of SIRT1 and CD38, which are proteins that play important roles in cellular processes that normally decline with age.
To investigate the effects of NMN and its underlying mechanisms in mice with Alzheimer's disease. Age-related complication: Alzheimer’s disease NMN dose: 100 mg/kg body weight/every other day (subcutaneously)
Study Type
Animal study (mice)
Purpose
To investigate the effects of NMN and its underlying mechanisms in mice with Alzheimer's disease. Age-related complication: Alzheimer’s disease NMN dose: 100 mg/kg body weight/every other day (subcutaneously)
Duration
28 days
Results
NMN substantially improved cognitive impairments, neuroinflammation, beta-amyloid pathology and synaptic loss. Both beta-amyloid pathology (plaques) and synaptic loss are key features of Alzheimer's disease and are associated with cognitive decline and memory problems characteristic of the condition.
To investigate the effect of NMN on cognitive outcomes in aged rats. Age-related complication: Cognitive impairment due to ageing NMN dose: 100 mg/kg body weight/ every other day
Study Type
Animal study (aged rats)
Purpose
To investigate the effect of NMN on cognitive outcomes in aged rats. Age-related complication: Cognitive impairment due to ageing NMN dose: 100 mg/kg body weight/ every other day
Duration
28 days
Results
NMN had neuroprotective effects, reduced cognitive decline and helped improve age-associated memory and learning impairments.
Exercise performance
Randomised double-blind placebo-controlled trial NMN dose: There were 3 different dosage groups and a placebo group: 300 mg/day (low dosage group) 600 mg/day (medium dosage group) 1200 mg/day (high dosage group) Each group consisted of 10 male participants and 2 female participants.
Study Type
Randomised double-blind placebo-controlled trial NMN dose: There were 3 different dosage groups and a placebo group: 300 mg/day (low dosage group) 600 mg/day (medium dosage group) 1200 mg/day (high dosage group) Each group consisted of 10 male participants and 2 female participants.
Participants
48 young and middle-aged recreational runners
Duration
6 weeks
Results
The researchers observed significant improvements in aerobic capacity (a measure of the body's ability to take in, transport, and utilise oxygen during sustained physical activity) and the endurance of amateur runners during exercise training after NMN supplementation, when compared to the placebo group. These improvements were dose dependent, meaning that the higher the NMN dose, the greater the effect on aerobic capacity and endurance. The authors attribute this improvement to enhanced oxygen utilisation in skeletal muscles. The moderate and higher doses were associated with greater improvements in aerobic capacity than the lower dose.
To investigate the effects of the time-dependent intake of nicotinamide mononucleotide (NMN) on sleep quality, fatigue, and physical performance in older adults. NMN dosage: 250 mg or a placebo either in the morning or in the evening to compare the effect of intake at different times.
Study Type
Randomised double-blind placebo-controlled trial
Purpose
To investigate the effects of the time-dependent intake of nicotinamide mononucleotide (NMN) on sleep quality, fatigue, and physical performance in older adults. NMN dosage: 250 mg or a placebo either in the morning or in the evening to compare the effect of intake at different times.
Participants
108 male and female participants with an average age of 73 years
Duration
12 weeks
Results
The participants in the study reported reduced drowsiness after NMN supplementation. The study also revealed an association between NMN intake in the afternoon and significant improvements in lower limb function which include lower body strength, balance, and functional mobility (the ability to move and perform daily tasks without difficulty). Overall, the authors concluded that NMN may have the potential to improve fatigue and prevent the loss of physical performance.
Safety
To investigate the safety of orally administered NMN and its efficacy to increase NAD+ levels. NMN dose: 250 mg/day or a placebo
Study Type
Randomised, double blind, parallel-group trial
Purpose
To investigate the safety of orally administered NMN and its efficacy to increase NAD+ levels. NMN dose: 250 mg/day or a placebo
Participants
30 healthy subjects
Duration
12 weeks
Results
Oral supplementation of NMN for 12 weeks caused no abnormalities in physiological and laboratory tests, and no obvious adverse effects were observed. NAD+ levels in whole blood were significantly increased after NMN administration. NAD+ plays a vital role in multiple cellular processes, and an increase in its levels suggests that the body has additional support for these vital processes, potentially resulting in favourable impacts on overall health and well-being. The authors concluded that oral administration of NMN may be a safe and practical strategy to boost NAD+ levels in humans.
To evaluate the safety of 1250mg of β-NMN administered orally once daily. NMN dose: 1250 mg/day or a placebo
Study Type
Randomised, double-blind, placebo-controlled, parallel-group trial
Purpose
To evaluate the safety of 1250mg of β-NMN administered orally once daily. NMN dose: 1250 mg/day or a placebo
Participants
31 healthy adult men and women aged 20-65
Duration
4 weeks
Results
The researchers observed that oral administration of 1250 mg of NMN once daily for 4 weeks did not result in any severe adverse events during the study period. The findings suggest that NMN is safe and well-tolerated in healthy adults.
To verify the safety of NMN administered through human veins. NMN dose: 300 mg dissolved in 100mL of salt solution
Study Type
Uncontrolled exploratory trial
Purpose
To verify the safety of NMN administered through human veins. NMN dose: 300 mg dissolved in 100mL of salt solution
Participants
5 males and 5 females (aged 20-70)
Duration
12 weeks
Results
The study found an association between intravenous NMN administration and increased blood NAD+, a vital molecule that helps keep proper cell functioning and supports various aspects of overall health, without damaging blood cells. Researchers also observed that NMN did not affect the participants’ heart's electrical activity, pulse, or blood pressure. It also did not impact metabolic markers in the liver, heart, pancreas, and kidneys. Additionally, the researchers noted a reduction in blood triglyceride (fat) levels after NMN administration. Elevated triglyceride levels have been linked to an increased risk of heart disease and other health issues. Intravenous administration normally carries a higher risk of damaging major organs compared to oral administration. This is because nutrients and drugs administered intravenously circulate directly in the blood without going through the liver, the body's centre for detoxification. These findings indicate that intravenous NMN administration is not only safe but also potentially beneficial for humans.
To investigate the safety of single NMN administration in 10 healthy men NMN dose: 100, 250, and 500 mg (single administrations)
Study Type
Uncontrolled trial
Purpose
To investigate the safety of single NMN administration in 10 healthy men NMN dose: 100, 250, and 500 mg (single administrations)
Duration
Acute (5 hours)
Results
The study found an association between NMN administration and a significant increase in the levels of NMN metabolites, the chemical compounds produced as a result of the metabolic processes of NMN. Previous research has already demonstrated a positive correlation between changes in NMN metabolite levels and changes in NAD+, a crucial component in cell functions such as energy production and DNA repair. Therefore, an increase in these NMN metabolites may indicate an elevation in NAD+ levels, potentially benefiting overall health and addressing age-related concerns. In addition, a single oral administration of NMN up to 500 mg was safe and well-tolerated in healthy men. No significant adverse effects were observed. The authors concluded that oral administration of NMN is feasible and could be used as a potential therapeutic strategy to replenish cellular NAD+ levels to mitigate age-related functional disorders in humans.
To evaluate the anti-aging effect of NMN and its safety in middle-aged and older adults NMN dose: 300 mg of NMN (2 x 150 mg capsules) or a placebo
Study Type
Randomised, double-blind, placebo-controlled, parallel-group trial
Purpose
To evaluate the anti-aging effect of NMN and its safety in middle-aged and older adults NMN dose: 300 mg of NMN (2 x 150 mg capsules) or a placebo
Participants
66 healthy subjects aged 40-65 years
Duration
60 days
Results
At day 30, NMN was associated with an 11.3% increase in molecules called NAD+/NADH that play crucial roles in various processes within the cells, whereas no change was observed in the placebo group. At day 50, there was a further 38% increase in these molecules compared to baseline, whereas there was only a 14.3% increase in the placebo group. Higher levels of NAD+ have been correlated with higher energy levels and an anti-ageing effect. NMN was also associated with increased sensitivity to insulin, which is beneficial as it indicates that the body is better managing blood sugar levels. There was a slight change in the “HOMA” measurement of insulin sensitivity in the NMN group (0.6%), whereas there was a noteworthy rise in the placebo group (30.6%). An increase in this measurement indicates a decrease in insulin sensitivity. A decrease in insulin sensitivity has been linked to ageing and is detrimental as it indicates that the body cells respond to insulin in regulating blood sugar levels.. However, there was no significant difference in the HOMA IR Index between the NMN group and placebo group.
Frequently Asked Questions
Common questions about NMN research
There are currently 22 peer-reviewed studies on NMN (Nicotinamide Mononucleotide), involving 471 total participants. Research covers Anti-ageing, NAD+ Levels, Diabetes and 3 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (11 human studies, 11 animal studies), and reported outcomes.
NMN has been researched for: Anti-ageing, NAD+ Levels, Diabetes, Alzheimer's disease, Exercise performance, Safety. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 11 out of 22 studies are human trials. The remaining 11 are animal studies. Human trials carry more weight in our evidence scoring system.
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