Maitake Mushroom
Research reviewed: 2022-2023
Maitake Mushroom (Grifola frondosa) is a dietary supplement with 6 published peer-reviewed studies involving 153 participants, researched for Immune Support, Blood Sugar Balance, Cognitive Function and 1 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Immune Support
ModerateBlood Sugar Balance
ModerateCognitive Function
ModerateAthletic Performance
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Immune Support
To evaluate immunological effects of Grifola frondosa extract in breast cancer patients.
Study Type
Phase I/II clinical trial
Purpose
To evaluate immunological effects of Grifola frondosa extract in breast cancer patients.
Dose
Oral Maitake D-fraction extract
Participants
34 breast cancer patients
Duration
3 weeks
Results
Bidirectional immunomodulatory effects demonstrated: maitake modulated multiple immune measures. Supports potential for clinical immunomodulation in cancer context.
How They Measured It
NK cell activity, lymphocyte proliferation, cytokine profiles
To assess whether maitake MD-fraction can aid cancer patients.
Study Type
Non-randomised case series
Purpose
To assess whether maitake MD-fraction can aid cancer patients.
Dose
MD-fraction 50-150mg + whole maitake powder 4-6g daily
Participants
35 cancer patients (liver, breast, lung, stomach, ovary)
Duration
Variable
Results
Tumor regression or symptom improvement in 58.3% of liver, 68.8% of breast, 62.5% of lung cancer cases. Enhanced NK cell and macrophage activity observed.
How They Measured It
Tumor regression, immune cell activity, symptom assessment
To evaluate effect of Maitake D-Fraction on NK cell activation in cancer patients.
Study Type
Clinical study
Purpose
To evaluate effect of Maitake D-Fraction on NK cell activation in cancer patients.
Dose
Maitake D-fraction 20-35mg/kg body weight
Participants
36 cancer patients
Duration
4 weeks
Results
Significant NK cell activation in cancer patients. NK cell activity increased 1.2-1.7 fold. Combination with standard therapy showed synergistic immune benefits.
How They Measured It
NK cell cytotoxicity, T cell counts, immune activation markers
Blood Sugar Balance
To assess Maitake SX-fraction effect on blood glucose control in type 2 diabetes.
Study Type
Pilot clinical study
Purpose
To assess Maitake SX-fraction effect on blood glucose control in type 2 diabetes.
Dose
SX-fraction 5mg/kg twice daily
Participants
30 non-insulin-dependent diabetic patients
Duration
2 months
Results
Significant reduction in insulin resistance index. Improved fasting blood glucose. SX-fraction demonstrated meaningful insulin-sensitizing properties.
How They Measured It
Insulin resistance index, fasting blood glucose, HbA1c
Cognitive Function
Medicinal Mushroom Supplements in Cancer: A Systematic Review of Clinical Studies.
Study Type
Meta-Analysis
Purpose
Medicinal Mushroom Supplements in Cancer: A Systematic Review of Clinical Studies.
Dose
See study
Participants
12 participants
Duration
Not specified
Results
Study results available at linked source.
How They Measured It
PubMed PMID: 36995535. Curr Oncol Rep
Athletic Performance
Effect of Maitake D-fraction in advanced laryngeal and pharyngeal cancers during concurrent chemoradiotherapy: A randomized clinical trial.
Study Type
RCT
Purpose
Effect of Maitake D-fraction in advanced laryngeal and pharyngeal cancers during concurrent chemoradiotherapy: A randomized clinical trial.
Dose
See study
Participants
141 participants
Duration
5 weeks
Results
CONCLUSION: In conclusion, this randomized clinical trial demonstrated that in advanced laryngeal and pharyngeal cancer patients, the oral administration of Maitake D-Fraction alleviated CCRT-relate.
How They Measured It
PubMed PMID: 36070433. Acta Biochim Pol
Frequently Asked Questions
Common questions about Maitake Mushroom research
There are currently 6 peer-reviewed studies on Maitake Mushroom (Grifola frondosa), involving 153 total participants. Research covers Immune support, Blood sugar balance, Cancer support and 1 more areas. The overall evidence strength is rated as Moderate.
The evidence is currently rated as "Moderate Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (6 human studies), and reported outcomes.
Maitake Mushroom has been researched for: Immune support, Blood sugar balance, Cancer support, Cholesterol management. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 6 out of 6 studies are human trials. Human trials carry more weight in our evidence scoring system.
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