Immunoglobulins
Research reviewed: 2000–2018
Immunoglobulins (Bovine immunoglobulins (IgG)) is a dietary supplement with 8 published peer-reviewed studies involving 654 participants, researched for Gut Health, Immune Function, Gut Permeability and 1 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Gut Health
StrongImmune Function
ModerateGut Permeability
ModerateMuscle Recovery & Performance
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Gut Health
Evaluate bovine immunoglobulin concentrate on gut health in IBS
Study Type
Randomised Controlled Trial
Purpose
Evaluate bovine immunoglobulin concentrate on gut health in IBS
Dose
5 g/day bovine IgG
Participants
80
Duration
8 weeks
Results
Significant improvement in IBS symptoms; reduced gut permeability; quality of life scores improved vs placebo
How They Measured It
IBS-SSS, stool frequency, quality of life, gut permeability
Assess serum-derived bovine immunoglobulin (SBI) for IBS
Study Type
Randomised Controlled Trial
Purpose
Assess serum-derived bovine immunoglobulin (SBI) for IBS
Dose
5 g/day SBI
Participants
66
Duration
8 weeks
Results
SBI significantly reduced IBS-SSS by 35% vs placebo; bowel habit normalised; faecal calprotectin reduced
How They Measured It
IBS-SSS, bowel habits, inflammatory markers
Test bovine IgG on gut health and microbiome composition
Study Type
Randomised Controlled Trial
Purpose
Test bovine IgG on gut health and microbiome composition
Dose
10 g/day
Participants
55
Duration
12 weeks
Results
Improved gut microbiome diversity; reduced pathogenic bacteria; SCFA production increased; inflammation markers reduced
How They Measured It
16S rRNA sequencing, SCFA, inflammatory markers
Immune Function
Assess bovine immunoglobulins on mucosal immune function
Study Type
Randomised Controlled Trial
Purpose
Assess bovine immunoglobulins on mucosal immune function
Dose
10 g/day
Participants
90
Duration
12 weeks
Results
sIgA significantly elevated; NK cell activity improved; fewer upper respiratory infections vs placebo
How They Measured It
Secretory IgA, NK cell activity, infection frequency
Evaluate serum bovine immunoglobulin on gut permeability
Study Type
Randomised Controlled Trial
Purpose
Evaluate serum bovine immunoglobulin on gut permeability
Dose
5 g/day SBI
Participants
48
Duration
4 weeks
Results
Significant reduction in gut permeability markers; zonulin reduced; intestinal barrier integrity improved
How They Measured It
Lactulose:mannitol ratio, zonulin, inflammatory markers
Gut Permeability
Test bovine immunoglobulin on gut permeability in exercising adults
Study Type
Randomised Controlled Trial
Purpose
Test bovine immunoglobulin on gut permeability in exercising adults
Dose
10 g/day
Participants
50
Duration
4 weeks
Results
Significant reduction in exercise-induced gut permeability increase; plasma LPS reduced; ZO-1 expression maintained
How They Measured It
Lactulose:mannitol ratio, plasma LPS, ZO-1 expression
Muscle Recovery & Performance
Evaluate bovine immunoglobulins as protein supplement for muscle recovery
Study Type
Randomised Controlled Trial
Purpose
Evaluate bovine immunoglobulins as protein supplement for muscle recovery
Dose
10 g/day in protein shake
Participants
120
Duration
8 weeks
Results
Lean mass gains comparable to whey; muscle damage markers lower; DOMS severity reduced; immune markers maintained
How They Measured It
Lean mass, strength, muscle damage markers (CK, DOMS)
Assess serum bovine immunoglobulin clinical outcomes in GI conditions
Study Type
Observational Clinical Study
Purpose
Assess serum bovine immunoglobulin clinical outcomes in GI conditions
Dose
5–10 g/day
Participants
145
Duration
8 weeks
Results
Clinically meaningful improvements in GI symptoms, bloating, and quality of life across IBS and IBD patients
How They Measured It
GI symptoms, inflammatory markers, quality of life
Frequently Asked Questions
Common questions about Immunoglobulins research
There are currently 8 peer-reviewed studies on Immunoglobulins (Bovine immunoglobulins (IgG)), involving 654 total participants. Research covers Gut Health, Immune Function, Muscle Recovery and 1 more areas. The overall evidence strength is rated as Very Strong.
The evidence is currently rated as "Very Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (8 human studies), and reported outcomes.
Immunoglobulins has been researched for: Gut Health, Immune Function, Muscle Recovery, Gut Permeability. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 8 out of 8 studies are human trials. Human trials carry more weight in our evidence scoring system.
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