Aloe Vera
Research reviewed: Up until 03/2026
Aloe Vera (Aloe barbadensis) is a dietary supplement with 25 published peer-reviewed studies involving 1,088 participants, researched for Skin Health & Wound Healing, Blood Sugar Control, Gut Health and 2 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Skin Health & Wound Healing
ModerateBlood Sugar Control
ModerateGut Health
StrongSystematic reviews
WeakClinical trials
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Skin Health & Wound Healing
To review clinical trials on Aloe vera for skin wound prevention and healing
Study Type
Systematic review
Purpose
To review clinical trials on Aloe vera for skin wound prevention and healing
Dose
Various topical formulations
Participants
Multiple RCTs reviewed
Duration
Various
Results
Aloe vera significantly accelerated wound healing in minor burns and surgical wounds across the majority of included trials.
How They Measured It
Wound healing time, skin parameters
To evaluate Aloe vera 0.5% cream on psoriasis vulgaris
Study Type
Randomised controlled trial
Purpose
To evaluate Aloe vera 0.5% cream on psoriasis vulgaris
Dose
0.5% cream applied three times daily
Participants
60 patients with psoriasis
Duration
16 weeks
Results
Aloe vera cream achieved significantly higher clinical remission rates (83.3%) vs placebo (6.6%) with no side effects.
How They Measured It
PASI score, skin biopsy
To assess Aloe vera mouthwash on oral mucositis in chemotherapy patients
Study Type
Randomised controlled trial
Purpose
To assess Aloe vera mouthwash on oral mucositis in chemotherapy patients
Dose
Oral rinse with Aloe vera
Participants
58 cancer patients
Duration
3 weeks
Results
Aloe vera mouthwash significantly reduced severity and pain of oral mucositis compared to chlorhexidine (p<0.05).
How They Measured It
WHO mucositis scale, pain VAS
Blood Sugar Control
To evaluate Aloe vera on glycaemic control
Study Type
Systematic review and meta-analysis
Purpose
To evaluate Aloe vera on glycaemic control
Dose
Various
Participants
9 RCTs, 537 participants
Duration
4-12 weeks
Results
Aloe vera significantly reduced fasting blood glucose (-46.6 mg/dL) and HbA1c in pre-diabetic and diabetic patients. PMID: 26687403
How They Measured It
Fasting blood glucose, HbA1c, insulin
To assess Aloe vera gel on type 2 diabetes blood sugar and lipids
Study Type
Randomised controlled trial
Purpose
To assess Aloe vera gel on type 2 diabetes blood sugar and lipids
Dose
300 mg/day dried gel powder
Participants
72 type 2 diabetic patients
Duration
8 weeks
Results
Aloe vera significantly reduced fasting blood glucose and triglycerides compared to placebo in type 2 diabetics.
How They Measured It
Fasting glucose, HbA1c, lipid profile
To investigate Aloe vera hypoglycaemic activity in diabetic rat models
Study Type
Animal study
Purpose
To investigate Aloe vera hypoglycaemic activity in diabetic rat models
Dose
200 mg/kg leaf extract
Participants
Streptozotocin-induced diabetic rats
Duration
42 days
Results
Aloe vera significantly reduced blood glucose in both type I and type II diabetic rat models with dose-dependent effects. PMID: 11268118
How They Measured It
Blood glucose, insulin levels
Gut Health
To evaluate Aloe vera gel in active ulcerative colitis
Study Type
Randomised controlled trial
Purpose
To evaluate Aloe vera gel in active ulcerative colitis
Dose
100 mL gel twice daily
Participants
44 patients with active ulcerative colitis
Duration
4 weeks
Results
Aloe vera gel achieved clinical response in 47% vs 14% placebo (OR 5.36, p=0.04) and remission in 30% vs 7%.
How They Measured It
SCCAI score, histology
To evaluate Aloe vera on IBS symptoms
Study Type
Randomised controlled trial
Purpose
To evaluate Aloe vera on IBS symptoms
Dose
Aloe vera liquid 100 mL twice daily
Participants
58 IBS patients
Duration
1 month
Results
Aloe vera significantly reduced pain and discomfort in IBS-D patients compared to placebo (p<0.05).
How They Measured It
IBS symptom score, stool frequency
To assess Aloe vera on blood lipids in hyperlipidemic patients
Study Type
Randomised controlled trial
Purpose
To assess Aloe vera on blood lipids in hyperlipidemic patients
Dose
300 mg/day
Participants
90 hyperlipidemic patients
Duration
12 weeks
Results
Aloe vera supplementation significantly reduced total cholesterol and LDL-C levels compared to placebo with no adverse effects.
How They Measured It
Total cholesterol, LDL, triglycerides
To review nutritional and metabolic effects of Aloe vera
Study Type
Review
Purpose
To review nutritional and metabolic effects of Aloe vera
Dose
Various
Participants
N/A
Duration
N/A
Results
Aloe vera contains acemannan, aloesin, and aloe-emodin with demonstrated effects on blood sugar, GI inflammation, and wound healing. Multiple evidence-based mechanisms identified.
How They Measured It
Literature review
Systematic reviews
To investigate the effects of Aloe Vera in the evaluation of periodontal ligament cell viability for an avulsed tooth using various storage media: a systematic review and meta-analysis.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Aloe Vera in the evaluation of periodontal ligament cell viability for an avulsed tooth using various storage media: a systematic review and meta-analysis.
Dose
Aloe Vera (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
Many storage mediums are available for the storage of avulsed teeth to preserve the viability of periodontal ligament (PDL) cells before replantation; however, it is unclear which medium is the optimal option .
How They Measured It
See study for outcome measures
To investigate the effects of Aloe Vera in antibiofilm effects of novel compounds in otitis media treatment: systematic review.
Study Type
Systematic review
Purpose
To investigate the effects of Aloe Vera in antibiofilm effects of novel compounds in otitis media treatment: systematic review.
Dose
Aloe Vera (dose not specified)
Participants
125 participants
Duration
Duration not specified
Results
cation were examined in five studies. This systematic review indicates that some compounds like NAC, prebiotics, nanoparticles and MESNA that have significant effects on biofilm are safe and could be researched more extensively for further clinical use. However, a lack of data about reliable and efficient compounds used in therapy of different types of otitis media still remains in the literature.
How They Measured It
See study for outcome measures
To investigate the effects of Aloe Vera in clinical effect of local aloe vera use as an adjunct to periodontal therapy: a systematic review and meta-analysis.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Aloe Vera in clinical effect of local aloe vera use as an adjunct to periodontal therapy: a systematic review and meta-analysis.
Dose
Aloe Vera (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
Aloe Vera might be beneficial to improve periodontal condition. This systematic review and meta-analysis aimed to investigate Aloe Vera's clinical efficacy as an adjunct to scaling and root planning (SRP) for nonsurgical periodontal therapy.
How They Measured It
See study for outcome measures
To investigate the effects of Aloe Vera in effectiveness of aloe vera in the treatment of oral mucositis: a systematic review and meta-analysis of randomized controlled trials.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Aloe Vera in effectiveness of aloe vera in the treatment of oral mucositis: a systematic review and meta-analysis of randomized controlled trials.
Dose
Aloe Vera (dose not specified)
Participants
355 participants
Duration
Duration not specified
Results
a subgroup analysis was conducted. A subgroup analysis showed significant improvement in grade 3 and 4 OM for AV versus placebo (odds ratio 0.22, 95% CI 0.11-0.44, P < 0.001), but not compared with sodium bicarbonate or benzydamine. The results suggest that AV may be beneficial for cancer patients undergoing radiotherapy or chemotherapy, leading to improvements in the more severe stages of OM.
How They Measured It
See study for outcome measures
To investigate the effects of Aloe Vera in different disinfection strategies in bacterial and biofilm contamination on dental unit waterlines: a systematic review.
Study Type
Systematic review
Purpose
To investigate the effects of Aloe Vera in different disinfection strategies in bacterial and biofilm contamination on dental unit waterlines: a systematic review.
Dose
Aloe Vera (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
The aim of this systematic review is to explore the effectiveness of different methods of reducing contamination and biofilms in dental unit waterlines (DUWLs) and to provide reference for future standardisation of disinfection practices in dental clinic.
How They Measured It
See study for outcome measures
To investigate the effects of Aloe Vera in the effect of different mouthwashes to prevent oral mucositis in patients with radiotherapy and chemotherapy: a network meta-analysis.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Aloe Vera in the effect of different mouthwashes to prevent oral mucositis in patients with radiotherapy and chemotherapy: a network meta-analysis.
Dose
Aloe Vera (dose not specified)
Participants
Participants not specified
Duration
13 months
Results
nts undergoing with radiotherapy and chemotherapy. Most studies are comparisons of two arms or three groups, resulting in the lack of direct comparative trial evidence for all care fluids.Therefore, it is not clear which mouthwash is better for preventing the occurrence of OM in patients. This study compares the preventive effects of13 mouthwashes currently used to treat OM in different countries.
How They Measured It
See study for outcome measures
To investigate the effects of Aloe Vera in a comprehensive systematic review of natural biomedicines for immune-mediated and inflammatory dermatologic diseases.
Study Type
Systematic review
Purpose
To investigate the effects of Aloe Vera in a comprehensive systematic review of natural biomedicines for immune-mediated and inflammatory dermatologic diseases.
Dose
Aloe Vera (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
Natural biomedicines (NBMs) are frequently used to manage immune-mediated and inflammatory dermatologic diseases (IMIDDs). This systematic review evaluates the efficacy, safety, and clinical relevance of NBMs in IMIDDs, providing an evidence-based analysis to guide dermatologic practice.
How They Measured It
See study for outcome measures
To investigate the effects of Aloe Vera in the efficacy of aloe vera against enterococcus faecalis as an intracanal medicament: a systematic review and meta-analysis.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Aloe Vera in the efficacy of aloe vera against enterococcus faecalis as an intracanal medicament: a systematic review and meta-analysis.
Dose
Aloe Vera (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
en size, mean, and standard deviation value of the outcome in CFU, at 95% confidence intervals. AV exhibits bactericidal qualities that are equal to or comparable to those of CaOH. AV displayed a nonsignificantly reduced CFU count than CaOH in a meta-analysis (p > 0.05). In summary, AV exhibits antibacterial/antimicrobial capabilities against E. faecalis that are equal to or comparable to CaOH.
How They Measured It
See study for outcome measures
To investigate the effects of Aloe Vera in clinical effectiveness of aloe vera gel as an adjunct to mechanical debridement in patients with periodontitis: a systematic review and meta-analysis.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Aloe Vera in clinical effectiveness of aloe vera gel as an adjunct to mechanical debridement in patients with periodontitis: a systematic review and meta-analysis.
Dose
Aloe Vera (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
This study aimed to evaluate the clinical effect of aloe vera gel as an adjunct to scaling and root planing (SRP) on plaque index (PI), gingival index (GI), and probing pocket depth (PPD) in periodontitis treatment.
How They Measured It
See study for outcome measures
Clinical trials
To investigate the effects of Aloe Vera in decreased inflammatory biomarkers after using artificial tears with aloe vera and hypromellose for dry eye.
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Aloe Vera in decreased inflammatory biomarkers after using artificial tears with aloe vera and hypromellose for dry eye.
Dose
Aloe Vera (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
Research has increasingly highlighted the therapeutic potential of Aloe vera and hypromellose for treating dry eye due to their healing properties and multifaceted benefits including anti-inflammatory, antioxidant, antimicrobial, and wetting capabilities.
How They Measured It
See study for outcome measures
To investigate the effects of Aloe Vera in efficacy of an iranian herbal medicine formula for postoperative constipation in trauma patients with hip and lower limb fractures: a triple-blind, pl
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Aloe Vera in efficacy of an iranian herbal medicine formula for postoperative constipation in trauma patients with hip and lower limb fractures: a triple-blind, pl
Dose
Aloe Vera (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
(POC) in patients undergoing surgeries for traumatic fractures of the hip or lower extremities. The HLC is a novel polyherbal formulation that integrates both scientifically validated botanicals, such as Cassia angustifolia and Aloe barbadensis, with traditionally employed herbs like Foeniculum vulgare, Coriandrum sativum, and Carum carvi, all of which are recognized for their laxative properties.
How They Measured It
See study for outcome measures
To investigate the effects of Aloe Vera in a split-mouth, randomized, double-blind clinical trial of a gelatin hemostatic dental sponge containing aloe vera nanoparticles for controlling bleedi
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Aloe Vera in a split-mouth, randomized, double-blind clinical trial of a gelatin hemostatic dental sponge containing aloe vera nanoparticles for controlling bleedi
Dose
Aloe Vera (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
le materials and fast hemostats that can help blood clotting in the surgical site and quick repair of the dental surgery site. In this study, we investigated the bleeding control (blood absorption ability and active bleeding) of a hemostatic gelatin sponge containing aloe vera nanoparticles as a hemostatic material after the removal of mandibular posterior teeth in a doubleblind, randomized trial.
How They Measured It
See study for outcome measures
To investigate the effects of Aloe Vera in a randomized controlled trial on the therapeutic effect of aloe vera extract on diabetic foot ulcers.
Study Type
Clinical study
Purpose
To investigate the effects of Aloe Vera in a randomized controlled trial on the therapeutic effect of aloe vera extract on diabetic foot ulcers.
Dose
Aloe Vera (dose not specified)
Participants
60 participants
Duration
Duration not specified
Results
This single-blinded randomized controlled trial shows that topical aloe vera significantly improves DFU healing compared to standard care. Its effects are likely due to the promotion of angiogenesis, reduction in inflammation, and antimicrobial action. Aloe vera is a safe, affordable option, especially for low-resource settings. Larger studies with longer follow-up are needed to confirm and expand
How They Measured It
See study for outcome measures
To investigate the effects of Aloe Vera in effectiveness of chlorhexidine and aloe vera mouthwash in patients with periodontal disease: a randomized controlled trial.
Study Type
Clinical study
Purpose
To investigate the effects of Aloe Vera in effectiveness of chlorhexidine and aloe vera mouthwash in patients with periodontal disease: a randomized controlled trial.
Dose
Aloe Vera (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
Aloe vera has gained significant attention in clinical research, and promoting natural substances is a prevailing trend in dentistry.
How They Measured It
See study for outcome measures
To investigate the effects of Aloe Vera in supporting respiratory epithelia and lowering inflammation to effectively treat common cold symptoms: a randomized controlled trial.
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Aloe Vera in supporting respiratory epithelia and lowering inflammation to effectively treat common cold symptoms: a randomized controlled trial.
Dose
6 mg
Participants
157 participants
Duration
Duration not specified
Results
2.26 [95% CI -3.04 to -1.47] (-38%)), Treatment 2 (-3.81 [95% CI -4.82 to -2.80];(-53%)), Treatment 3 (-4.49 [95% CI -5.62 to -3.57];(-69%)). As a result of this study, we conclude that supporting upper respiratory epithelia and reducing COX-mediated inflammation may be used to effectively treat common cold symptoms. Trial registration: ClinicalTrials.gov Identifier: NCT06106880 Posted 30/10/2023.
How They Measured It
See study for outcome measures
Frequently Asked Questions
Common questions about Aloe Vera research
There are currently 25 peer-reviewed studies on Aloe Vera (Aloe barbadensis), involving 1,088 total participants. Research covers Skin Health & Wound Healing, Blood Sugar Control, Gut Health and 2 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (12 human studies, 1 animal study), and reported outcomes.
Aloe Vera has been researched for: Skin Health & Wound Healing, Blood Sugar Control, Gut Health, Systematic reviews, Clinical trials. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 12 out of 25 studies are human trials. The remaining 1 is an animal study. Human trials carry more weight in our evidence scoring system.
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