Aloe Vera
Research reviewed: Up until 03/2026
Aloe Vera (Aloe barbadensis) is a dietary supplement with 10 published peer-reviewed studies involving 680 participants, researched for Skin Health & Wound Healing, Blood Sugar Control, Gut Health.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Skin Health & Wound Healing
StrongBlood Sugar Control
ModerateGut Health
StrongResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Skin Health & Wound Healing
To review clinical trials on Aloe vera for skin wound prevention and healing
Study Type
Systematic review
Purpose
To review clinical trials on Aloe vera for skin wound prevention and healing
Dose
Various topical formulations
Participants
Multiple RCTs reviewed
Duration
Various
Results
Aloe vera significantly accelerated wound healing in minor burns and surgical wounds across the majority of included trials.
How They Measured It
Wound healing time, skin parameters
To evaluate Aloe vera 0.5% cream on psoriasis vulgaris
Study Type
Randomised controlled trial
Purpose
To evaluate Aloe vera 0.5% cream on psoriasis vulgaris
Dose
0.5% cream applied three times daily
Participants
60 patients with psoriasis
Duration
16 weeks
Results
Aloe vera cream achieved significantly higher clinical remission rates (83.3%) vs placebo (6.6%) with no side effects.
How They Measured It
PASI score, skin biopsy
To assess Aloe vera mouthwash on oral mucositis in chemotherapy patients
Study Type
Randomised controlled trial
Purpose
To assess Aloe vera mouthwash on oral mucositis in chemotherapy patients
Dose
Oral rinse with Aloe vera
Participants
58 cancer patients
Duration
3 weeks
Results
Aloe vera mouthwash significantly reduced severity and pain of oral mucositis compared to chlorhexidine (p<0.05).
How They Measured It
WHO mucositis scale, pain VAS
Blood Sugar Control
To evaluate Aloe vera on glycaemic control
Study Type
Systematic review and meta-analysis
Purpose
To evaluate Aloe vera on glycaemic control
Dose
Various
Participants
9 RCTs, 537 participants
Duration
4-12 weeks
Results
Aloe vera significantly reduced fasting blood glucose (-46.6 mg/dL) and HbA1c in pre-diabetic and diabetic patients. PMID: 26687403
How They Measured It
Fasting blood glucose, HbA1c, insulin
To assess Aloe vera gel on type 2 diabetes blood sugar and lipids
Study Type
Randomised controlled trial
Purpose
To assess Aloe vera gel on type 2 diabetes blood sugar and lipids
Dose
300 mg/day dried gel powder
Participants
72 type 2 diabetic patients
Duration
8 weeks
Results
Aloe vera significantly reduced fasting blood glucose and triglycerides compared to placebo in type 2 diabetics.
How They Measured It
Fasting glucose, HbA1c, lipid profile
To investigate Aloe vera hypoglycaemic activity in diabetic rat models
Study Type
Animal study
Purpose
To investigate Aloe vera hypoglycaemic activity in diabetic rat models
Dose
200 mg/kg leaf extract
Participants
Streptozotocin-induced diabetic rats
Duration
42 days
Results
Aloe vera significantly reduced blood glucose in both type I and type II diabetic rat models with dose-dependent effects. PMID: 11268118
How They Measured It
Blood glucose, insulin levels
Gut Health
To evaluate Aloe vera gel in active ulcerative colitis
Study Type
Randomised controlled trial
Purpose
To evaluate Aloe vera gel in active ulcerative colitis
Dose
100 mL gel twice daily
Participants
44 patients with active ulcerative colitis
Duration
4 weeks
Results
Aloe vera gel achieved clinical response in 47% vs 14% placebo (OR 5.36, p=0.04) and remission in 30% vs 7%.
How They Measured It
SCCAI score, histology
To evaluate Aloe vera on IBS symptoms
Study Type
Randomised controlled trial
Purpose
To evaluate Aloe vera on IBS symptoms
Dose
Aloe vera liquid 100 mL twice daily
Participants
58 IBS patients
Duration
1 month
Results
Aloe vera significantly reduced pain and discomfort in IBS-D patients compared to placebo (p<0.05).
How They Measured It
IBS symptom score, stool frequency
To assess Aloe vera on blood lipids in hyperlipidemic patients
Study Type
Randomised controlled trial
Purpose
To assess Aloe vera on blood lipids in hyperlipidemic patients
Dose
300 mg/day
Participants
90 hyperlipidemic patients
Duration
12 weeks
Results
Aloe vera supplementation significantly reduced total cholesterol and LDL-C levels compared to placebo with no adverse effects.
How They Measured It
Total cholesterol, LDL, triglycerides
To review nutritional and metabolic effects of Aloe vera
Study Type
Review
Purpose
To review nutritional and metabolic effects of Aloe vera
Dose
Various
Participants
N/A
Duration
N/A
Results
Aloe vera contains acemannan, aloesin, and aloe-emodin with demonstrated effects on blood sugar, GI inflammation, and wound healing. Multiple evidence-based mechanisms identified.
How They Measured It
Literature review
Frequently Asked Questions
Common questions about Aloe Vera research
There are currently 10 peer-reviewed studies on Aloe Vera (Aloe barbadensis), involving 680 total participants. Research covers Skin health & wound healing, Blood sugar control, Gut health. The overall evidence strength is rated as Very Strong.
The evidence is currently rated as "Very Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (9 human studies, 1 animal study), and reported outcomes.
Aloe Vera has been researched for: Skin health & wound healing, Blood sugar control, Gut health. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 9 out of 10 studies are human trials. The remaining 1 is an animal study. Human trials carry more weight in our evidence scoring system.
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