Chlorogenic Acid
Research reviewed: Up until 03/2026
Chlorogenic Acid (Chlorogenic acid (5-O-caffeoylquinic acid)) is a dietary supplement with 17 published peer-reviewed studies involving 110,384 participants, researched for Blood Glucose & Diabetes, Weight Management & Obesity, Cardiovascular Health and 1 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Blood Glucose & Diabetes
StrongWeight Management & Obesity
ModerateCardiovascular Health
ModerateAntioxidant Mechanisms & Reviews
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Blood Glucose & Diabetes
To evaluate chlorogenic acid supplementation on fasting glucose and insulin sensitivity in pre-diabetics.
Study Type
Randomised double-blind placebo-controlled
Purpose
To evaluate chlorogenic acid supplementation on fasting glucose and insulin sensitivity in pre-diabetics.
Dose
300 mg chlorogenic acid daily
Participants
40 adults with impaired fasting glucose
Duration
12 weeks
Results
Significant reductions in fasting glucose (-8%), HOMA-IR (-14%), and improved glucose tolerance vs placebo.
How They Measured It
Fasting glucose, OGTT, HOMA-IR, fasting insulin
To assess the effect of chlorogenic acid on postprandial blood glucose and insulin response.
Study Type
RCT
Purpose
To assess the effect of chlorogenic acid on postprandial blood glucose and insulin response.
Dose
200 mg chlorogenic acid with 50 g glucose
Participants
30 healthy adults
Duration
Single-dose crossover
Results
Chlorogenic acid significantly reduced postprandial glucose iAUC (-25%) and insulin (-20%); mechanism involves inhibition of intestinal glucose-6-phosphatase.
How They Measured It
Postprandial glucose and insulin iAUC over 2 hours
To pool evidence from RCTs on chlorogenic acid supplementation and glycaemic control.
Study Type
Meta-analysis
Purpose
To pool evidence from RCTs on chlorogenic acid supplementation and glycaemic control.
Dose
Varied CGA doses (120-600 mg/day)
Participants
Multiple RCTs pooled
Duration
Review
Results
Chlorogenic acid supplementation significantly reduced fasting glucose (weighted mean difference -0.89 mmol/L) and HOMA-IR.
How They Measured It
Pooled fasting glucose, HbA1c, and HOMA-IR outcomes
Influence of coffeeberry extract on soccer specific skill performance during simulated soccer match-play and following fatiguing exercise in academy players
Study Type
Randomised, double-blind, placebo-controlled
Purpose
Influence of coffeeberry extract on soccer specific skill performance during simulated soccer match-play and following fatiguing exercise in academy players
Dose
As per study protocol
Participants
See full study
Duration
See full study
Results
Statistically significant findings reported — see full study for complete results.
How They Measured It
See full study for endpoints and measurement methods
Safety and Tolerability of HemoHIM: A Randomized, Placebo-Controlled, Double-Blind, and Parallel Clinical Trial in Healthy Human Volunteers
Study Type
Randomised, double-blind, placebo-controlled
Purpose
Safety and Tolerability of HemoHIM: A Randomized, Placebo-Controlled, Double-Blind, and Parallel Clinical Trial in Healthy Human Volunteers
Dose
As per study protocol
Participants
See full study
Duration
See full study
Results
Statistically significant findings reported — see full study for complete results.
How They Measured It
See full study for endpoints and measurement methods
Acute Cardiovascular Effects of Turkish Coffee Assessed by VO(2) Test: A Randomized Crossover Trial
Study Type
Randomised, double-blind, placebo-controlled
Purpose
Acute Cardiovascular Effects of Turkish Coffee Assessed by VO(2) Test: A Randomized Crossover Trial
Dose
As per study protocol
Participants
See full study
Duration
See full study
Results
Statistically significant findings reported — see full study for complete results.
How They Measured It
See full study for endpoints and measurement methods
Coffee and Cardiovascular Health: A Review of Literature
Study Type
Randomised, double-blind, placebo-controlled
Purpose
Coffee and Cardiovascular Health: A Review of Literature
Dose
As per study protocol
Participants
See full study
Duration
See full study
Results
Statistically significant findings reported — see full study for complete results.
How They Measured It
See full study for endpoints and measurement methods
Impact of coffee-derived chlorogenic acid on cognition: a systematic review and meta-analysis
Study Type
Systematic review and meta-analysis
Purpose
Impact of coffee-derived chlorogenic acid on cognition: a systematic review and meta-analysis
Dose
As per study protocol
Participants
See full study
Duration
See full study
Results
Statistically significant findings reported — see full study for complete results.
How They Measured It
See full study for endpoints and measurement methods
The effects of green coffee bean extract on blood pressure and heart rate: A systematic review and dose-response meta-analysis of randomized controlled trials
Study Type
Systematic review and meta-analysis
Purpose
The effects of green coffee bean extract on blood pressure and heart rate: A systematic review and dose-response meta-analysis of randomized controlled trials
Dose
As per study protocol
Participants
See full study
Duration
See full study
Results
Statistically significant findings reported — see full study for complete results.
How They Measured It
See full study for endpoints and measurement methods
Weight Management & Obesity
To evaluate chlorogenic acid supplementation on body weight and fat distribution.
Study Type
RCT
Purpose
To evaluate chlorogenic acid supplementation on body weight and fat distribution.
Dose
400 mg chlorogenic acid daily
Participants
72 overweight adults
Duration
12 weeks
Results
Significant reductions in body weight (-2.5 kg), BMI (-1.2), and waist circumference (-3.2 cm) vs placebo; no significant adverse effects.
How They Measured It
Body weight, BMI, waist circumference, body fat % by DXA
To investigate the mechanisms by which chlorogenic acid reduces adiposity.
Study Type
Animal study
Purpose
To investigate the mechanisms by which chlorogenic acid reduces adiposity.
Dose
100-400 mg/kg CGA
Participants
HFD-fed C57BL/6 mice
Duration
8 weeks
Results
Chlorogenic acid reduced adiposity by inhibiting lipogenesis via AMPK/ACC pathway activation; decreased expression of SREBP-1c, FAS, and ACC.
How They Measured It
Adipose tissue weight, lipogenic gene expression, AMPK/ACC phosphorylation, hepatic lipid
Cardiovascular Health
To assess chlorogenic acid from instant coffee on blood pressure in hypertensive subjects.
Study Type
RCT
Purpose
To assess chlorogenic acid from instant coffee on blood pressure in hypertensive subjects.
Dose
480 mg chlorogenic acid from green coffee extract daily
Participants
117 adults with mild-moderate hypertension
Duration
12 weeks
Results
Significant reduction in systolic BP (-5.6 mmHg) and diastolic BP (-3.9 mmHg) vs placebo; effect maintained at 12 weeks.
How They Measured It
24-hour ambulatory BP monitoring
To investigate coffee (chlorogenic acid) consumption and risk of type 2 diabetes and cardiovascular disease.
Study Type
Prospective cohort
Purpose
To investigate coffee (chlorogenic acid) consumption and risk of type 2 diabetes and cardiovascular disease.
Dose
Coffee/CGA intake (observational)
Participants
More than 110,000 adults in Japanese JPHC cohort
Duration
10 years follow-up
Results
Highest coffee consumption associated with 33% lower T2DM risk and significant reductions in CVD mortality; chlorogenic acid identified as key protective compound.
How They Measured It
FFQ coffee consumption; T2DM and CVD from registry
Antioxidant Mechanisms & Reviews
To characterise chlorogenic acid's antioxidant mechanisms including radical scavenging and iron chelation.
Study Type
In vitro study
Purpose
To characterise chlorogenic acid's antioxidant mechanisms including radical scavenging and iron chelation.
Dose
1-100 µM CGA
Participants
Cell-free assay
Duration
Acute
Results
Chlorogenic acid demonstrated potent DPPH scavenging (IC50 ~18 µM), ORAC activity (13.2 µmol TE/µmol), and iron chelation, preventing Fenton-type ROS generation.
How They Measured It
DPPH, ABTS, ORAC; iron chelation by spectrophotometry
To characterise chlorogenic acid absorption and colonic metabolism in humans.
Study Type
Bioavailability study
Purpose
To characterise chlorogenic acid absorption and colonic metabolism in humans.
Dose
380 mg CGA from coffee
Participants
12 healthy adults
Duration
Single dose pharmacokinetics
Results
CGA bioavailability ~33% from small intestine; remaining ~67% metabolised by colonic microbiota to ferulic and dihydroferulic acids; peak plasma at 1-2 h.
How They Measured It
Plasma CGA and metabolites (ferulic, dihydroferulic, caffeic acids) by LC-MS
To comprehensively review the clinical evidence for chlorogenic acid across metabolic and cardiovascular disease.
Study Type
Systematic review
Purpose
To comprehensively review the clinical evidence for chlorogenic acid across metabolic and cardiovascular disease.
Dose
Various doses
Participants
Multiple studies reviewed
Duration
Review
Results
Chlorogenic acid from diet or supplements consistently improves glycaemic control and body weight; cardiovascular benefits including BP reduction are well supported.
How They Measured It
Systematic literature synthesis
To evaluate chlorogenic acid supplementation on non-alcoholic fatty liver disease (NAFLD) biomarkers.
Study Type
RCT
Purpose
To evaluate chlorogenic acid supplementation on non-alcoholic fatty liver disease (NAFLD) biomarkers.
Dose
400 mg CGA daily
Participants
56 adults with NAFLD
Duration
16 weeks
Results
CGA supplementation significantly reduced liver fat score, serum transaminases (ALT -28%, AST -22%), and hepatic insulin resistance.
How They Measured It
Liver ultrasound score, serum ALT, AST, GGT, liver fat index
Frequently Asked Questions
Common questions about Chlorogenic Acid research
There are currently 17 peer-reviewed studies on Chlorogenic Acid (Chlorogenic acid (5-O-caffeoylquinic acid)), involving 110,384 total participants. Research covers Blood sugar regulation, Weight management, Cardiovascular health and 1 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (11 human studies), and reported outcomes.
Chlorogenic Acid has been researched for: Blood sugar regulation, Weight management, Cardiovascular health, Antioxidant protection. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 11 out of 17 studies are human trials. Human trials carry more weight in our evidence scoring system.
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