Aged Garlic Extract (AGE)
Research reviewed: Up until 03/2026
Aged Garlic Extract (AGE) (Aged garlic extract (Allium sativum)) is a dietary supplement with 18 published peer-reviewed studies involving 1,928 participants, researched for Cardiovascular Health, Immune Modulation, Antioxidant & Anti-inflammatory Effects and 3 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Cardiovascular Health
ModerateImmune Modulation
ModerateAntioxidant & Anti-inflammatory Effects
ModerateCancer Prevention & Review
ModerateSystematic reviews
WeakClinical trials
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Cardiovascular Health
To evaluate aged garlic extract on coronary artery calcium progression.
Study Type
Randomised double-blind placebo-controlled
Purpose
To evaluate aged garlic extract on coronary artery calcium progression.
Dose
2400 mg AGE daily
Participants
55 patients with intermediate cardiovascular risk
Duration
12 months
Results
AGE significantly slowed progression of CAC vs placebo (net difference -1.5 AU); also reduced homocysteine and CRP.
How They Measured It
Coronary artery calcium (CAC) score by CT scan
To evaluate AGE supplementation on blood pressure in hypertensive patients.
Study Type
RCT
Purpose
To evaluate AGE supplementation on blood pressure in hypertensive patients.
Dose
1200 mg AGE daily
Participants
79 hypertensive adults
Duration
12 weeks
Results
Significant reduction in systolic BP (-10 mmHg) and diastolic BP (-5 mmHg) vs placebo; effect maintained at 12 weeks.
How They Measured It
24-hour ambulatory blood pressure monitoring
To pool evidence from RCTs on aged garlic extract and blood pressure reduction.
Study Type
Meta-analysis
Purpose
To pool evidence from RCTs on aged garlic extract and blood pressure reduction.
Dose
Various doses reviewed
Participants
Multiple RCTs pooled
Duration
Review
Results
AGE supplementation significantly reduced systolic BP (mean -8.2 mmHg, 95% CI -4.1 to -12.3); comparable to first-line antihypertensive agents for mild hypertension.
How They Measured It
Pooled BP outcomes from RCTs
To assess AGE supplementation on lipid profiles and arterial stiffness.
Study Type
RCT
Purpose
To assess AGE supplementation on lipid profiles and arterial stiffness.
Dose
2400 mg AGE daily
Participants
50 adults with dyslipidaemia
Duration
16 weeks
Results
Significant reductions in total cholesterol (-10%), LDL-C (-14%), and triglycerides (-12%); arterial stiffness (PWV) improved significantly.
How They Measured It
Fasting lipid panel, pulse wave velocity, ankle-brachial index
Immune Modulation
To evaluate AGE supplementation on cold and flu incidence and severity.
Study Type
Randomised double-blind placebo-controlled
Purpose
To evaluate AGE supplementation on cold and flu incidence and severity.
Dose
2400 mg AGE daily
Participants
120 adults during winter season
Duration
3 months
Results
AGE group had 61% fewer colds; shorter duration (-21%) and reduced severity when illness occurred vs placebo.
How They Measured It
Self-reported cold/flu incidence, severity, duration diary
To evaluate AGE on immune function in elderly adults.
Study Type
RCT
Purpose
To evaluate AGE on immune function in elderly adults.
Dose
2400 mg AGE daily
Participants
72 adults aged 65+
Duration
6 weeks
Results
Significant enhancement of NK cell cytotoxicity (+39%) and improved phagocytic activity vs placebo.
How They Measured It
NK cell cytotoxicity, T-cell subsets, phagocytosis by neutrophils
Antioxidant & Anti-inflammatory Effects
To evaluate aged garlic extract on oxidative stress markers in patients with metabolic syndrome.
Study Type
RCT
Purpose
To evaluate aged garlic extract on oxidative stress markers in patients with metabolic syndrome.
Dose
2400 mg AGE daily
Participants
58 adults with metabolic syndrome
Duration
12 weeks
Results
Significant reduction in oxidative stress markers (MDA -30%, 8-OHdG -22%) and increase in endogenous antioxidant enzymes.
How They Measured It
Serum MDA, 8-OHdG, glutathione, ORAC
To characterise AGE's antioxidant active compounds and radical scavenging mechanisms.
Study Type
In vitro mechanistic study
Purpose
To characterise AGE's antioxidant active compounds and radical scavenging mechanisms.
Dose
Various AGE fractions
Participants
Cell-free assay
Duration
Acute
Results
AGE's antioxidant activity was primarily attributed to S-allylcysteine, S-allylmercaptocysteine, and fructosyl-arginine (FruArg); superior to raw garlic for water-soluble radicals.
How They Measured It
DPPH, ABTS, and hydroxyl radical scavenging; HPLC profiling of S-allylcysteine, FruArg
Cancer Prevention & Review
To investigate AGE/garlic intake and stomach cancer risk.
Study Type
Case-control study
Purpose
To investigate AGE/garlic intake and stomach cancer risk.
Dose
Garlic intake (observational)
Participants
1024 gastric cancer cases, 1963 controls
Duration
Case-control
Results
High garlic/AGE intake associated with 54% lower gastric cancer risk (OR 0.46, 95% CI 0.38-0.57).
How They Measured It
FFQ garlic consumption; gastric cancer case-control
To assess AGE effect on colorectal adenoma recurrence after polypectomy.
Study Type
RCT
Purpose
To assess AGE effect on colorectal adenoma recurrence after polypectomy.
Dose
2400 mg AGE daily
Participants
51 patients after colorectal polypectomy
Duration
12 months
Results
AGE supplementation significantly reduced adenoma recurrence (37% in AGE group vs 65% in control); size of recurrent adenomas also smaller.
How They Measured It
Colonoscopy-confirmed adenoma recurrence at 12 months
To synthesise clinical evidence on AGE for cardiovascular, immune, and cancer outcomes.
Study Type
Systematic review
Purpose
To synthesise clinical evidence on AGE for cardiovascular, immune, and cancer outcomes.
Dose
Various doses
Participants
Multiple studies reviewed
Duration
Review
Results
AGE has strong clinical evidence for blood pressure reduction and immune enhancement; promising cancer preventive effects, particularly for gastric and colorectal cancers.
How They Measured It
Comprehensive literature synthesis
To assess long-term AGE supplement users vs non-users on cardiovascular events.
Study Type
Observational cohort
Purpose
To assess long-term AGE supplement users vs non-users on cardiovascular events.
Dose
AGE supplement use (observational)
Participants
400 adults aged 50+ followed for cardiovascular events
Duration
5 years
Results
Regular AGE users had significantly fewer cardiovascular events (HR 0.63) and lower incidence of hypertension progression.
How They Measured It
Cardiovascular event registry; self-reported AGE use
Systematic reviews
To investigate the effects of Aged Garlic Extract (AGE) in effect of garlic extract on markers of lipid metabolism and inflammation in coronary artery disease (cad) patients: a systematic review and meta-analy
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Aged Garlic Extract (AGE) in effect of garlic extract on markers of lipid metabolism and inflammation in coronary artery disease (cad) patients: a systematic review and meta-analy
Dose
Aged Garlic Extract (AGE) (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
#x2009;-2.66 to -0.57; p = .003). In the case of subgroup analysis, the overall effect was significantly effective in reducing TC, LDL levels and improving HDL levels in CV risk patients. Our study findings provide consistent evidence that intake of garlic reduces CVD risk factors. However, garlic could be considered a safe natural medicine to debilitate inflammation in CAD patients.
How They Measured It
See study for outcome measures
To investigate the effects of Aged Garlic Extract (AGE) in effects of aged garlic extract on blood pressure in hypertensive patients: a systematic review and meta-analysis of randomized controlled trials.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Aged Garlic Extract (AGE) in effects of aged garlic extract on blood pressure in hypertensive patients: a systematic review and meta-analysis of randomized controlled trials.
Dose
Aged Garlic Extract (AGE) (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
There is no consensus based on the existing literature regarding the effect of aged garlic extract (AGE) on blood pressure. The present systematic review and meta-analysis was conducted to synthesize existing data from randomized clinical trials (RCTs) concerning the impact of AGE supplementation on blood pressure in hypertensive patients.
How They Measured It
See study for outcome measures
Clinical trials
To investigate the effects of Aged Garlic Extract (AGE) in traditional vietnamese medicine containing garlic extract for patients with non-severe covid-19: a phase-ii, double-blind, randomized controlled trial
Study Type
Clinical study
Purpose
To investigate the effects of Aged Garlic Extract (AGE) in traditional vietnamese medicine containing garlic extract for patients with non-severe covid-19: a phase-ii, double-blind, randomized controlled trial
Dose
0068 g
Participants
19 participants
Duration
11 days
Results
TD0068 is safe but does not show an effect for non-severe COVID-19 patients. Further research is needed to explore the potential benefits of garlic in other forms or dosages for the treatment of COVID-19.
How They Measured It
See study for outcome measures
To investigate the effects of Aged Garlic Extract (AGE) in randomized, double-blind clinical trial evaluating the impact of freeze-dried garlic extract capsules on blood pressure, lipid profile, and nitric oxi
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Aged Garlic Extract (AGE) in randomized, double-blind clinical trial evaluating the impact of freeze-dried garlic extract capsules on blood pressure, lipid profile, and nitric oxi
Dose
Aged Garlic Extract (AGE) (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
Hypertension, substantially heightens the risk of cardiovascular disease. This study aims to evaluate the effectiveness of freeze-dried garlic extract in blood pressure and lipid profiles in prehypertensive individuals.
How They Measured It
See study for outcome measures
To investigate the effects of Aged Garlic Extract (AGE) in l-arginine and aged garlic extract for the prevention of migraine: a study protocol for a randomised, double-blind, placebo-controlled, phase-ii trial
Study Type
Clinical trial
Purpose
To investigate the effects of Aged Garlic Extract (AGE) in l-arginine and aged garlic extract for the prevention of migraine: a study protocol for a randomised, double-blind, placebo-controlled, phase-ii trial
Dose
Aged Garlic Extract (AGE) (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
a dilatory phenotype, may reduce frequency and/or severity of migraines. The primary aim of the L-Arginine and Aged Garlic Extract (LARGE) trial is to investigate whether oral treatment with dietary nutraceuticals, L-arginine and aged garlic extract (AGE), both systemic vasodilatory agents, will alleviate migraine frequency, duration and severity in adults with chronic frequent episodic migraines.
How They Measured It
See study for outcome measures
To investigate the effects of Aged Garlic Extract (AGE) in improved microvascular reactivity after aged garlic extract intake is not mediated by hydrogen sulfide in older adults at risk for cardiovascular dise
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Aged Garlic Extract (AGE) in improved microvascular reactivity after aged garlic extract intake is not mediated by hydrogen sulfide in older adults at risk for cardiovascular dise
Dose
Aged Garlic Extract (AGE) (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
nvestigate the effects of AGE on microvascular reactivity, systolic blood pressure (SBP), and diastolic blood pressure (DBP) in older individuals at high risk for cardiovascular disease (CVD). Urinary thiosulfate was also investigated as an indirect marker of endogenous hydrogen sulfide (H 2 S) synthesis. The study was conducted in a randomized, double-blind, crossover, and placebo-controlled way.
How They Measured It
See study for outcome measures
Frequently Asked Questions
Common questions about Aged Garlic Extract (AGE) research
There are currently 18 peer-reviewed studies on Aged Garlic Extract (AGE) (Aged garlic extract (Allium sativum)), involving 1,928 total participants. Research covers Cardiovascular Health, Immune Modulation, Antioxidant & Anti-inflammatory Effects and 3 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (13 human studies), and reported outcomes.
Aged Garlic Extract (AGE) has been researched for: Cardiovascular Health, Immune Modulation, Antioxidant & Anti-inflammatory Effects, Cancer Prevention & Review, Systematic reviews, Clinical trials. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 13 out of 18 studies are human trials. Human trials carry more weight in our evidence scoring system.
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