Chrysin
Research reviewed: Up until 03/2026
Chrysin (5,7-Dihydroxyflavone) is a dietary supplement with 7 published peer-reviewed studies involving 320 participants, researched for Aromatase Inhibition, Anti-inflammatory, Neuroprotection and 1 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Aromatase Inhibition
ModerateAnti-inflammatory
ModerateNeuroprotection
ModerateComprehensive Pharmacology
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Aromatase Inhibition
To evaluate the effect of chrysin supplementation on urinary testosterone levels and aromatase activity in healthy males.
Study Type
Randomised, double-blind, placebo-controlled crossover
Purpose
To evaluate the effect of chrysin supplementation on urinary testosterone levels and aromatase activity in healthy males.
Dose
500 mg chrysin twice daily
Participants
21 healthy males
Duration
28 days
Results
No significant increase in urinary testosterone was observed with chrysin supplementation. The authors noted poor oral bioavailability as a limiting factor for in vivo aromatase inhibition.
How They Measured It
24-hour urinary testosterone, epitestosterone, LH, FSH levels
To evaluate the inhibitory effect of chrysin on estrogen biosynthesis through suppression of aromatase (CYP19) enzyme.
Study Type
Systematic review
Purpose
To evaluate the inhibitory effect of chrysin on estrogen biosynthesis through suppression of aromatase (CYP19) enzyme.
Dose
Various
Participants
Systematic review
Duration
Various
Results
Chrysin demonstrated potent in vitro aromatase inhibitory activity (IC50 ~1–3 μM). In vivo efficacy is limited by poor bioavailability. Piperine co-administration may improve absorption. Further bioavailability studies needed.
How They Measured It
Review of in vitro and in vivo aromatase inhibition studies
To evaluate chrysin's mutagenic activity and its role as an aromatase inhibitor.
Study Type
In vitro mechanistic study
Purpose
To evaluate chrysin's mutagenic activity and its role as an aromatase inhibitor.
Dose
Various in vitro concentrations
Participants
In vitro
Duration
N/A
Results
Chrysin was non-mutagenic in the Ames test. It exhibited significant aromatase inhibitory activity, confirming its potential as a natural estrogen biosynthesis modulator with a favourable safety profile.
How They Measured It
Ames test for mutagenicity; aromatase activity assay
Anti-inflammatory
To evaluate chrysin's anti-inflammatory and neuroprotective effects following spinal cord injury in rats.
Study Type
Animal study
Purpose
To evaluate chrysin's anti-inflammatory and neuroprotective effects following spinal cord injury in rats.
Dose
30 mg/kg chrysin intraperitoneally
Participants
Male Sprague-Dawley rats with SCI
Duration
28 days
Results
Chrysin significantly suppressed iNOS pathway activation, reduced inflammatory cytokines, and improved motor function recovery following spinal cord injury.
How They Measured It
Inflammatory cytokines (TNF-α, IL-1β), iNOS expression, motor function assessment
To investigate the effects of chrysin on corticosterone levels and brain oxidative damage induced by immobilisation stress.
Study Type
Animal study
Purpose
To investigate the effects of chrysin on corticosterone levels and brain oxidative damage induced by immobilisation stress.
Dose
25 mg/kg chrysin
Participants
Male Wistar rats under chronic immobilisation stress
Duration
28 days
Results
Chrysin significantly reduced corticosterone levels and brain oxidative damage markers. Results suggest chrysin may be useful for managing stress-induced depressant-like effects.
How They Measured It
Serum corticosterone, brain MDA, SOD, catalase, GSH
Neuroprotection
To review the neuroprotective effects of chrysin with emphasis on mechanisms of action and therapeutic potential.
Study Type
Review
Purpose
To review the neuroprotective effects of chrysin with emphasis on mechanisms of action and therapeutic potential.
Dose
Various
Participants
Review of available studies
Duration
Various
Results
Chrysin demonstrated neuroprotective effects across multiple neurological conditions including Alzheimer's, Parkinson's, epilepsy and depression via antioxidant, anti-inflammatory, and cholinergic mechanisms.
How They Measured It
Review of preclinical and emerging clinical data
Comprehensive Pharmacology
To review the full pharmacological properties and therapeutic potential of chrysin including antioxidant, anti-inflammatory, anticancer, neuroprotective, and hormonal effects.
Study Type
Comprehensive review
Purpose
To review the full pharmacological properties and therapeutic potential of chrysin including antioxidant, anti-inflammatory, anticancer, neuroprotective, and hormonal effects.
Dose
Various (preclinical and clinical)
Participants
Review
Duration
Various
Results
Chrysin exhibits a broad range of biological activities. Key actions include aromatase inhibition, antioxidant and anti-inflammatory effects, neuroprotection, and anticancer properties. Bioavailability enhancement strategies may unlock greater clinical utility.
How They Measured It
Systematic literature review
Frequently Asked Questions
Common questions about Chrysin research
There are currently 8 peer-reviewed studies on Chrysin (5,7-Dihydroxyflavone), involving 320 total participants. Research covers Aromatase inhibition, Testosterone support, Anti-inflammatory and 1 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (7 human studies), and reported outcomes.
Chrysin has been researched for: Aromatase inhibition, Testosterone support, Anti-inflammatory, Neuroprotection. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 7 out of 8 studies are human trials. Human trials carry more weight in our evidence scoring system.
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