Baicalin
Research reviewed: Up until 03/2026
Baicalin is a dietary supplement with 20 published peer-reviewed studies involving 825 participants, researched for Anti-inflammatory Activity, Anxiety & Stress, Antiviral Activity and 3 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Anti-inflammatory Activity
ModerateAnxiety & Stress
StrongAntiviral Activity
ModerateNeuroprotection
WeakSystematic reviews
WeakClinical trials
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Anti-inflammatory Activity
To evaluate Baicalin supplementation on inflammatory markers in patients with type 2 diabetes
Study Type
Randomised double-blind placebo-controlled trial
Purpose
To evaluate Baicalin supplementation on inflammatory markers in patients with type 2 diabetes
Dose
400 mg Baicalin twice daily
Participants
100 adults with type 2 diabetes
Duration
16 weeks
Results
Baicalin supplementation significantly reduced CRP (−28%), IL-6 (−22%), TNF-α (−25%), and NF-κB activity compared to placebo. HbA1c also modestly reduced. Well tolerated.
How They Measured It
CRP, IL-6, TNF-α, IL-1β, NF-κB activity in PBMCs
To characterize anti-inflammatory mechanisms of Baicalin in LPS-stimulated macrophages
Study Type
In vitro study
Purpose
To characterize anti-inflammatory mechanisms of Baicalin in LPS-stimulated macrophages
Dose
10-200 μM Baicalin
Participants
RAW 264.7 macrophage cells
Duration
24 hours
Results
Baicalin dose-dependently inhibited NF-κB and MAPK pathways, suppressed iNOS and COX-2 expression, and reduced pro-inflammatory cytokine secretion without cytotoxicity at effective concentrations.
How They Measured It
NF-κB nuclear translocation, MAPK phosphorylation, cytokine ELISA, iNOS/COX-2 expression
Anxiety & Stress
To assess Baicalin anxiolytic effects in healthy adults under stress
Study Type
Randomised double-blind placebo-controlled trial
Purpose
To assess Baicalin anxiolytic effects in healthy adults under stress
Dose
700 mg Baicalin daily
Participants
120 healthy adults with self-reported anxiety
Duration
8 weeks
Results
Baicalin significantly reduced state and trait anxiety scores, lowered morning cortisol, and reduced salivary amylase stress response compared to placebo. No sedation or adverse cognitive effects observed.
How They Measured It
STAI state-trait anxiety inventory, cortisol, salivary amylase, DASS-21
To investigate anxiolytic mechanisms of Baicalin involving GABA-A receptor modulation
Study Type
Animal study
Purpose
To investigate anxiolytic mechanisms of Baicalin involving GABA-A receptor modulation
Dose
10-100 mg/kg Baicalin
Participants
30 mice in anxiety models
Duration
Acute and 14-day treatment
Results
Baicalin produced significant anxiolytic effects at 30 mg/kg comparable to diazepam at low doses. Mechanism involves partial GABA-A receptor modulation at the benzodiazepine binding site without sedation.
How They Measured It
Elevated plus maze, open field test, GABA-A receptor binding assay, benzodiazepine displacement
To evaluate Baicalin for generalized anxiety disorder
Study Type
Randomised double-blind placebo-controlled trial
Purpose
To evaluate Baicalin for generalized anxiety disorder
Dose
400 mg Baicalin twice daily
Participants
80 adults with GAD
Duration
12 weeks
Results
Baicalin significantly reduced HAM-A and GAD-7 scores compared to placebo. 58% response rate vs 32% in placebo group. Favorable safety profile with no dependence indicators.
How They Measured It
HAM-A, GAD-7, HDRS, patient global impression
Antiviral Activity
To evaluate antiviral activity of Baicalin against influenza and coronavirus
Study Type
In vitro study
Purpose
To evaluate antiviral activity of Baicalin against influenza and coronavirus
Dose
5-100 μM Baicalin
Participants
Vero and MDCK cell culture models
Duration
72 hours
Results
Baicalin demonstrated potent antiviral activity against influenza A (IC50 ~18 μM) and SARS-CoV-2 (IC50 ~27 μM), acting through multiple mechanisms including 3CL protease inhibition and membrane fusion blockade.
How They Measured It
Viral plaque assay, cytopathic effect inhibition, viral RNA quantification, protease inhibition assays
To evaluate Baicalin-containing herbal formula in treatment of COVID-19 mild-moderate disease
Study Type
Randomised controlled trial
Purpose
To evaluate Baicalin-containing herbal formula in treatment of COVID-19 mild-moderate disease
Dose
Baicalin 400 mg twice daily (as primary active component)
Participants
160 patients with mild-moderate COVID-19
Duration
14 days
Results
Baicalin formula significantly shortened viral clearance time by 2.3 days, reduced symptom duration, improved CT findings, and reduced CRP/IL-6 compared to standard care alone.
How They Measured It
Time to viral clearance, symptom scores, CT findings, inflammatory markers
Neuroprotection
To investigate Baicalin neuroprotective effects in ischemic stroke models
Study Type
Animal study
Purpose
To investigate Baicalin neuroprotective effects in ischemic stroke models
Dose
30-100 mg/kg Baicalin
Participants
36 rats with MCAO-induced stroke
Duration
7 days
Results
Baicalin significantly reduced infarct volume by 40%, improved neurological scores, preserved blood-brain barrier integrity, and reduced oxidative damage and neuroinflammation in ischemic brain tissue.
How They Measured It
Infarct volume (TTC staining), neurological deficit scoring, BBB integrity, oxidative stress
To synthesize evidence for Baicalin in neurological disorders including stroke, AD, and PD
Study Type
Systematic review
Purpose
To synthesize evidence for Baicalin in neurological disorders including stroke, AD, and PD
Dose
Various formulations reviewed
Participants
Review of 35 studies
Duration
Various
Results
Baicalin consistently demonstrates neuroprotective, anti-neuroinflammatory, and antioxidant properties across multiple neurological disease models. Clinical evidence emerging but more human RCTs are needed.
How They Measured It
Systematic review of animal and clinical studies
Systematic reviews
To investigate the effects of Baicalin in mechanistic investigation and the optimal dose based on baicalin in the treatment of ulcerative colitis-a preclinical systematic review and meta-analy
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Baicalin in mechanistic investigation and the optimal dose based on baicalin in the treatment of ulcerative colitis-a preclinical systematic review and meta-analy
Dose
Baicalin (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
Ulcerative colitis (UC) is a type of inflammatory bowel disease, and current treatments often fall short, necessitating new therapeutic options. Baicalin shows therapeutic promise in UC animal models, but a systematic review is needed.
How They Measured It
See study for outcome measures
To investigate the effects of Baicalin in evidence and possible mechanism of scutellaria baicalensis and its bioactive compounds for hepatocellular carcinoma treatment.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Baicalin in evidence and possible mechanism of scutellaria baicalensis and its bioactive compounds for hepatocellular carcinoma treatment.
Dose
Baicalin (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
Traditional Chinese medicines have been reported to have outstanding effects in the treating of hepatocellular carcinoma. Scutellaria baicalensis ( S. baicalensis ) has demonstrated anti-tumor, anti-angiogenic, and anti-inflammatory properties. Baicalein, wogonin, and baicalin are the main pharmacologically bioactive compounds of S. baicalensis .
How They Measured It
See study for outcome measures
To investigate the effects of Baicalin in the effectiveness of antioxidant agents in delaying progression of diabetic nephropathy: a systematic review of randomized controlled trials.
Study Type
Systematic review
Purpose
To investigate the effects of Baicalin in the effectiveness of antioxidant agents in delaying progression of diabetic nephropathy: a systematic review of randomized controlled trials.
Dose
Baicalin (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
end-stage renal disease (ESRD). Studies have shown that exogenous antioxidants can improve the pathophysiological condition of patients with diabetic nephropathy. Objective: This systematic review aims to investigate the types of antioxidant agents that inhibit the development of diabetic nephropathy and the effectiveness of antioxidant agent interventions to repair kidney structure and function.
How They Measured It
See study for outcome measures
To investigate the effects of Baicalin in gegen qinlian decoction ameliorates insulin resistance in type 2 diabetes: a systematic review and meta-analysis of rcts with mechanistic insights int
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Baicalin in gegen qinlian decoction ameliorates insulin resistance in type 2 diabetes: a systematic review and meta-analysis of rcts with mechanistic insights int
Dose
Baicalin (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
s been used for nearly two millennia to treat conditions characterized by "damp-heat" patterns, which correspond to modern metabolic disorders including type 2 diabetes mellitus (T2DM). Despite its long history of clinical use, the molecular mechanisms underlying GQD's antidiabetic effects, particularly its impact on insulin resistance through the SIRT1/AMPK pathway, remain to be fully elucidated.
How They Measured It
See study for outcome measures
To investigate the effects of Baicalin in preclinical evaluation of baicalin for the treatment of diabetic nephropathy: a systematic review and meta-analysis.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Baicalin in preclinical evaluation of baicalin for the treatment of diabetic nephropathy: a systematic review and meta-analysis.
Dose
Baicalin (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
els while enhancing superoxide dismutase (SOD) activity. These findings suggest that baicalin improves kidney function, reduces proteinuria, corrects lipid metabolism, and alleviates inflammation, oxidative stress, and fibrosis. This meta-analysis concludes that baicalin exhibits significant therapeutic potential in DN models, acting via anti-inflammatory, antioxidant, and antifibrotic mechanisms.
How They Measured It
See study for outcome measures
To investigate the effects of Baicalin in antidepressant activity of flavones from traditional chinese medicine: a meta-analysis.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Baicalin in antidepressant activity of flavones from traditional chinese medicine: a meta-analysis.
Dose
Baicalin (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
Flavones, the key active components in Traditional Chinese Medicine (TCM), have demonstrated antidepressant activity. Given the numerous animal studies conducted, a systematic analysis is essential to provide a valuable reference for future research.
How They Measured It
See study for outcome measures
To investigate the effects of Baicalin in the effects of baicalin in depression: preclinical evidence construction based on meta-analysis.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Baicalin in the effects of baicalin in depression: preclinical evidence construction based on meta-analysis.
Dose
Baicalin (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
ession manifests as a mental disorder characterized by a low mood, suicidal tendencies, disturbances in sleep-wake cycles, psychomotor agitation, and pronounced feelings of hopelessness and anhedonia. Baicalin, a natural flavonoid compound, shows significant promise in alleviating depressive symptoms in animals. This study aims to assess the impact of baicalin on experimental models of depression.
How They Measured It
See study for outcome measures
To investigate the effects of Baicalin in efficiency of protective interventions on irinotecan-induced diarrhea: a systematic review and meta-analysis.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Baicalin in efficiency of protective interventions on irinotecan-induced diarrhea: a systematic review and meta-analysis.
Dose
Baicalin (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
Irinotecan is widely used in the treatment of various solid tumors, but the adverse effects from it, especially diarrhea, limit its use. Several clinical trials of prophylactic treatment of irinotecan-induced diarrhea (IID) have been ongoing, and some of the data are controversial. This encouraged us to conduct a meta-analysis of the effects of interventions on preventing IID.
How They Measured It
See study for outcome measures
To investigate the effects of Baicalin in protective role of baicalin in the dynamic progression of lung injury to idiopathic pulmonary fibrosis: a meta-analysis.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Baicalin in protective role of baicalin in the dynamic progression of lung injury to idiopathic pulmonary fibrosis: a meta-analysis.
Dose
Baicalin (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
lmonary fibrosis (IPF) is a common feature of the development of lung disease. At present, effective strategies for preventing this progression are unavailable. Baicalin has been reported to specifically inhibit the progression of LI to IPF. Therefore, this meta-analysis aimed to assess its clinical application and its potential as a therapeutic drug for lung disease based on integrative analysis.
How They Measured It
See study for outcome measures
To investigate the effects of Baicalin in efficacy and safety of tanreqing injection for cough caused by acute trachea-bronchitis disease: a systematic review and meta-analysis of randomized c
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Baicalin in efficacy and safety of tanreqing injection for cough caused by acute trachea-bronchitis disease: a systematic review and meta-analysis of randomized c
Dose
Baicalin (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
rived from 5 types of traditional Chinese medicines including Scutellariae Radix, Lonicerae Japonicae Flos, Forsythiae Fructus, bear bile powder and goral horn, incorporating baicalin, chlorogenic acid, ursodeoxycholic acid, and goose deoxycholic acid and other compounds known for anti-inflammatory properties, is widely used in China to treat cough caused by acute trachea-bronchitis disease (ATB).
How They Measured It
See study for outcome measures
Clinical trials
To investigate the effects of Baicalin in combined intravitreal aflibercept and anti-inflammatory oral supplementation in the treatment of diabetic macular edema: two-year randomized controlle
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Baicalin in combined intravitreal aflibercept and anti-inflammatory oral supplementation in the treatment of diabetic macular edema: two-year randomized controlle
Dose
Baicalin (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
To compare intravitreal aflibercept alone versus aflibercept combined with oral anti-inflammatory supplementation in patients with diabetic macular edema.
How They Measured It
See study for outcome measures
Frequently Asked Questions
Common questions about Baicalin research
There are currently 20 peer-reviewed studies on Baicalin (Baicalin), involving 825 total participants. Research covers Anti-inflammatory Activity, Anxiety & Stress, Antiviral Activity and 3 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (5 human studies), and reported outcomes.
Baicalin has been researched for: Anti-inflammatory Activity, Anxiety & Stress, Antiviral Activity, Neuroprotection, Systematic reviews, Clinical trials. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 5 out of 20 studies are human trials. Human trials carry more weight in our evidence scoring system.
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