Bifidobacterium bifidum
Research reviewed: Up until 03/2026
Bifidobacterium bifidum is a dietary supplement with 22 published peer-reviewed studies involving 2,016 participants, researched for IBS & Gut Health, Immune Support & Allergy, H. pylori & Gastric Health and 2 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
IBS & Gut Health
StrongImmune Support & Allergy
StrongH. pylori & Gastric Health
ModerateClinical trials
WeakSystematic reviews
WeakResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
IBS & Gut Health
To evaluate B. bifidum MIMBb75 for IBS symptom relief.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate B. bifidum MIMBb75 for IBS symptom relief.
Dose
10^9 CFU/day
Participants
122 IBS patients
Duration
4 weeks
Results
B. bifidum MIMBb75 significantly improved global IBS symptoms (47% vs 11% responder rate). Pain, bloating, and urgency all significantly improved.
How They Measured It
Global IBS symptoms, individual symptom scores, quality of life
To confirm efficacy of B. bifidum MIMBb75 for IBS in a larger trial.
Study Type
Confirmatory double-blind, placebo-controlled
Purpose
To confirm efficacy of B. bifidum MIMBb75 for IBS in a larger trial.
Dose
10^9 CFU/day (heat-inactivated)
Participants
443 IBS patients
Duration
8 weeks
Results
Both live and heat-inactivated B. bifidum MIMBb75 significantly improved IBS-SSS scores compared to placebo. Adequate relief was achieved in significantly more patients.
How They Measured It
IBS-SSS, adequate relief, quality of life
Immune Support & Allergy
To evaluate B. bifidum on immune response to influenza vaccination in healthy adults.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate B. bifidum on immune response to influenza vaccination in healthy adults.
Dose
5 × 10^9 CFU/day
Participants
211 healthy adults
Duration
5 weeks
Results
B. bifidum significantly enhanced seroprotection rates and antibody responses to influenza vaccine. NK cell activity also increased.
How They Measured It
Seroprotection rates, IgG/IgA levels, NK cell activity
To evaluate B. bifidum supplementation in infants at high risk of allergy.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate B. bifidum supplementation in infants at high risk of allergy.
Dose
10^9 CFU/day
Participants
112 infants at high atopic risk
Duration
12 months
Results
B. bifidum significantly reduced eczema incidence at 12 months (18% vs 38% placebo). Total IgE was lower but allergen-specific IgE was not significantly different.
How They Measured It
Incidence of eczema, total and specific IgE levels
To assess B. bifidum on respiratory infections and intestinal health in elderly.
Study Type
Randomised controlled trial
Purpose
To assess B. bifidum on respiratory infections and intestinal health in elderly.
Dose
2 × 10^9 CFU/day
Participants
60 elderly volunteers
Duration
3 months
Results
B. bifidum significantly reduced duration of respiratory infections and increased fecal Bifidobacterium counts compared to placebo.
How They Measured It
Incidence and duration of respiratory infections, fecal microbiome
H. pylori & Gastric Health
To evaluate B. bifidum as adjunct to H. pylori eradication therapy.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate B. bifidum as adjunct to H. pylori eradication therapy.
Dose
5 × 10^9 CFU/day
Participants
82 H. pylori-positive patients
Duration
4 weeks
Results
B. bifidum supplementation improved H. pylori eradication rates (81% vs 68% placebo) and significantly reduced therapy-related GI side effects.
How They Measured It
H. pylori eradication rates, therapy side effects
To evaluate B. bifidum on gastric inflammation markers.
Study Type
Randomised, controlled
Purpose
To evaluate B. bifidum on gastric inflammation markers.
Dose
10^9 CFU/day
Participants
54 asymptomatic H. pylori carriers
Duration
12 weeks
Results
B. bifidum supplementation improved pepsinogen I/II ratio indicating reduced gastric inflammation. H. pylori antibody titers decreased.
How They Measured It
Serum pepsinogen I/II ratio, H. pylori antibodies
Clinical trials
To investigate the effects of Bifidobacterium bifidum in oral probiotics to prevent recurrent vulvovaginal infections during pregnancy-multicenter double-blind, randomized, placebo-controlled trial.
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Bifidobacterium bifidum in oral probiotics to prevent recurrent vulvovaginal infections during pregnancy-multicenter double-blind, randomized, placebo-controlled trial.
Dose
9 CFU
Participants
Participants not specified
Duration
4 months
Results
: The oral probiotic product tested in this study did not reduce the recurrence rate of VVIs in pregnant women following eradication.
How They Measured It
See study for outcome measures
To investigate the effects of Bifidobacterium bifidum in the effect of probiotics on health in pregnancy and infants: a randomized, double-blind, placebo-controlled trial.
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Bifidobacterium bifidum in the effect of probiotics on health in pregnancy and infants: a randomized, double-blind, placebo-controlled trial.
Dose
5 billion
Participants
90 participants
Duration
28 weeks
Results
Probiotic supplementation during the third trimester of pregnancy and lactation is a valid strategy for conferring benefits to mothers and infants.
How They Measured It
See study for outcome measures
To investigate the effects of Bifidobacterium bifidum in multistrain probiotics and telomere length in type 2 diabetes: a 24-week randomized controlled trial.
Study Type
Clinical study
Purpose
To investigate the effects of Bifidobacterium bifidum in multistrain probiotics and telomere length in type 2 diabetes: a 24-week randomized controlled trial.
Dose
Bifidobacterium bifidum (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
This 24-week randomized controlled trial aimed to evaluate the impact of multistrain probiotic supplementation on telomere length in patients with type 2 diabetes (T2DM). The study also assessed secondary outcomes including high-sensitivity C-reactive protein (hs-CRP) and glycated hemoglobin (HbA1c).
How They Measured It
See study for outcome measures
To investigate the effects of Bifidobacterium bifidum in efficacy of oral probiotic supplementation in preventing vulvovaginal infections during pregnancy: a randomized and placebo-controlled clinical trial.
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Bifidobacterium bifidum in efficacy of oral probiotic supplementation in preventing vulvovaginal infections during pregnancy: a randomized and placebo-controlled clinical trial.
Dose
Bifidobacterium bifidum (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
This study aimed to investigate the efficacy of oral probiotic supplementation in preventing vulvovaginal infections (VVIs) in pregnant women, specifically focusing on abnormal vaginal flora (AVF), bacterial vaginosis (BV), and vulvovaginal candidiasis (VVC).
How They Measured It
See study for outcome measures
To investigate the effects of Bifidobacterium bifidum in efficacy of probiotics in preventing chemotherapy-induced diarrhea in gastrointestinal cancer patients.
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Bifidobacterium bifidum in efficacy of probiotics in preventing chemotherapy-induced diarrhea in gastrointestinal cancer patients.
Dose
Bifidobacterium bifidum (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
n lead to significant health complications, including dehydration, electrolyte imbalances, and treatment interruptions. Recent studies have shown that the gut microbiome plays an important role in the development and severity of chemotherapy-induced diarrhea. Modulating the gut microbiome with probiotics has emerged as a potential strategy for preventing and managing chemotherapy-induced diarrhea.
How They Measured It
See study for outcome measures
To investigate the effects of Bifidobacterium bifidum in 12-week preoperative probiotic supplementation versus placebo: effects on inflammation, endotoxemia, adipokines, and gastrointestinal peptides in pati
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Bifidobacterium bifidum in 12-week preoperative probiotic supplementation versus placebo: effects on inflammation, endotoxemia, adipokines, and gastrointestinal peptides in pati
Dose
Bifidobacterium bifidum (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
Disruption in gut microbiota has been identified as a contributor to obesity-related inflammation and metabolic disorders. This study investigates the effects of preoperative probiotic supplementation on inflammation, endotoxemia, adipokines, and gastrointestinal peptides after bariatric surgery.
How They Measured It
See study for outcome measures
To investigate the effects of Bifidobacterium bifidum in effect of supplementation with a specific probiotic (bifidobacterium bifidum prl2010) in pregnancy for the prevention of atopic dermatitis in children
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Bifidobacterium bifidum in effect of supplementation with a specific probiotic (bifidobacterium bifidum prl2010) in pregnancy for the prevention of atopic dermatitis in children
Dose
Bifidobacterium bifidum (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the appearance of recurrent eczematous lesions and intense itching. The World Allergy Organization (WAO) suggested the administration of probiotics in pregnant women at high risk of allergies in their children.
How They Measured It
See study for outcome measures
To investigate the effects of Bifidobacterium bifidum in dual-strain probiotics bifidobacterium bifidum and lactobacillus acidophilus reverse gut dysbiosis in preterm neonates: a randomized controlled trial.
Study Type
Clinical study
Purpose
To investigate the effects of Bifidobacterium bifidum in dual-strain probiotics bifidobacterium bifidum and lactobacillus acidophilus reverse gut dysbiosis in preterm neonates: a randomized controlled trial.
Dose
Bifidobacterium bifidum (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
Preterm neonates exhibit gut dysbiosis, characterized by increased numbers of pathogenic bacteria and decreased Bifidobacterium and Lactobacillus levels. Supplementation with the probiotic Bifidobacterium bifidum/Lactobacillus acidophilus (BB/LA) may reverse gut dysbiosis.
How They Measured It
See study for outcome measures
To investigate the effects of Bifidobacterium bifidum in the effect of probiotic yogurt containing lactobacillus rhamnosus and bifidobacterium bifidum on disease activity and disability in patients with syst
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Bifidobacterium bifidum in the effect of probiotic yogurt containing lactobacillus rhamnosus and bifidobacterium bifidum on disease activity and disability in patients with syst
Dose
2 g
Participants
19 participants
Duration
13 weeks
Results
mount of protein, cholesterol, magnesium, zinc, selenium, and iron intake increased significantly after intervention. There are no significant changes in SLEDAI score and disability (HAQ) between case and control groups at the end of the study. Consumption of probiotic yogurt containing L rhamnosus and B bifidum did not have a significant short-term effect on SLEDAI and disability in SLE patients.
How They Measured It
See study for outcome measures
Systematic reviews
To investigate the effects of Bifidobacterium bifidum in symptomatologic outcomes of gut microbiota modifiers (probiotics, prebiotics and synbiotics) in cancer care: a scoping review of randomized controlled
Study Type
Review
Purpose
To investigate the effects of Bifidobacterium bifidum in symptomatologic outcomes of gut microbiota modifiers (probiotics, prebiotics and synbiotics) in cancer care: a scoping review of randomized controlled
Dose
Bifidobacterium bifidum (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
d clinical outcomes in individuals with cancer. However, there is a lack of comprehensive literature mapping to determine which specific cancer and treatment-related symptoms have been investigated as potential targets for gut microbiota modifiers. This scoping review aims to systematically analyze clinical trials on microbiota modifiers in managing cancer and treatment-related symptoms in adults.
How They Measured It
See study for outcome measures
To investigate the effects of Bifidobacterium bifidum in the use of probiotics and prebiotics can enable the ingestion of dairy products by lactose intolerant individuals.
Study Type
Systematic review
Purpose
To investigate the effects of Bifidobacterium bifidum in the use of probiotics and prebiotics can enable the ingestion of dairy products by lactose intolerant individuals.
Dose
Bifidobacterium bifidum (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
To investigate, through a systematic review, the efficiency of the clinical application of probiotic and prebiotic supplements in reducing the symptoms of lactose intolerance (LI).
How They Measured It
See study for outcome measures
To investigate the effects of Bifidobacterium bifidum in efficacy of probiotic supplementation in preventing necrotizing enterocolitis in preterm infants: a systematic review and meta-analysis.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Bifidobacterium bifidum in efficacy of probiotic supplementation in preventing necrotizing enterocolitis in preterm infants: a systematic review and meta-analysis.
Dose
Bifidobacterium bifidum (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
ants, involving intestinal inflammation and bacterial invasion, leading to high morbidity and mortality. Probiotics may reduce NEC by promoting beneficial gut bacteria, but the role of Bifidobacterium bifidum G001 (BBG001) is not well understood. This meta-analysis evaluates the effectiveness of BBG001 versus placebo in preventing NEC, late-onset sepsis, and all-cause mortality in preterm infants.
How They Measured It
See study for outcome measures
To investigate the effects of Bifidobacterium bifidum in effects of probiotic supplementation on immune and inflammatory markers in athletes: a meta-analysis of randomized clinical trials.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Bifidobacterium bifidum in effects of probiotic supplementation on immune and inflammatory markers in athletes: a meta-analysis of randomized clinical trials.
Dose
Bifidobacterium bifidum (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
: Probiotic supplementation resulted in significant positive changes in the IFN-γ and salivary IgA levels and negative changes in the IL-10 and TNF-α levels. No significant changes in the IL-1β, IL-2, IL-4, IL-6, IL-8, or CRP levels were observed after probiotic use in athletes.
How They Measured It
See study for outcome measures
To investigate the effects of Bifidobacterium bifidum in the effectiveness of probiotics as an adjunct therapy in patients under mechanical ventilation: an umbrella systematic review and meta-analysis.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Bifidobacterium bifidum in the effectiveness of probiotics as an adjunct therapy in patients under mechanical ventilation: an umbrella systematic review and meta-analysis.
Dose
Bifidobacterium bifidum (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
, B. salivarius , Pediococcus pentosaceus , Lactococcus raffinolactis , B. infantis , B. bifidum , Streptococcus thermophilus , Ligilactobacillus salivarius , L. lactis , B. lactis , Saccharomyces boulardii , L. rhamnosus GG, L. johnsonii , L. casei , S. faecalis , Clostridium butyricum , Bacillus mesentericus , L. sporogenes , S. boulardii , L. paracasei , B. subtilis , and Enterococcus faecium .
How They Measured It
See study for outcome measures
To investigate the effects of Bifidobacterium bifidum in efficacy of a probiotic combination on glycemic index and insulin resistance in adults: a systematic review and meta-analysis.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Bifidobacterium bifidum in efficacy of a probiotic combination on glycemic index and insulin resistance in adults: a systematic review and meta-analysis.
Dose
Bifidobacterium bifidum (dose not specified)
Participants
823 participants
Duration
Duration not specified
Results
ept the HOMA-B score) while no significant publication bias was observed. The current study suggests that the probiotic combination of Lactobacillus acidophilus , Lactobacillus casei , and Bifidobacterium bifidum is effective in reducing insulin resistance, improving glycemic index parameters, and improving pancreatic β-cell functioning in adults by improving the gastrointestinal microbiome.
How They Measured It
See study for outcome measures
Frequently Asked Questions
Common questions about Bifidobacterium bifidum research
There are currently 22 peer-reviewed studies on Bifidobacterium bifidum (Bifidobacterium bifidum), involving 2,016 total participants. Research covers IBS & Gut Health, Immune Support & Allergy, H. pylori & Gastric Health and 2 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (16 human studies), and reported outcomes.
Bifidobacterium bifidum has been researched for: IBS & Gut Health, Immune Support & Allergy, H. pylori & Gastric Health, Clinical trials, Systematic reviews. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 16 out of 22 studies are human trials. Human trials carry more weight in our evidence scoring system.
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