Amla
Research reviewed: Up until 03/2026
Amla (Phyllanthus emblica) is a dietary supplement with 22 published peer-reviewed studies involving 634 participants, researched for Cardiovascular & Cholesterol, Blood Sugar Regulation, Antioxidant & Immune Function and 3 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Cardiovascular & Cholesterol
ModerateBlood Sugar Regulation
ModerateAntioxidant & Immune Function
StrongHair & Skin Health
StrongClinical trials
ModerateSystematic reviews
WeakResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Cardiovascular & Cholesterol
To evaluate standardised amla extract on lipid profile in hypercholesterolaemic adults
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate standardised amla extract on lipid profile in hypercholesterolaemic adults
Dose
500 mg/day amla extract
Participants
98 adults with dyslipidaemia
Duration
12 weeks
Results
LDL reduced by 17.3% (p<0.001), total cholesterol by 12.1%, ApoB by 11.5%. HDL increased by 9.7%.
How They Measured It
Total cholesterol, LDL, HDL, triglycerides, ApoB
To compare amla vs simvastatin for lipid reduction in adults with dyslipidaemia
Study Type
Randomised, placebo-controlled
Purpose
To compare amla vs simvastatin for lipid reduction in adults with dyslipidaemia
Dose
1000 mg/day amla fruit powder
Participants
60 patients with mild-moderate hypercholesterolaemia
Duration
6 months
Results
Both amla and simvastatin significantly reduced total cholesterol and LDL. Amla also reduced triglycerides by 25% without affecting liver enzymes.
How They Measured It
Fasting lipid panel, liver enzymes
To evaluate amla effects on cardiovascular risk factors
Study Type
Systematic review and meta-analysis
Purpose
To evaluate amla effects on cardiovascular risk factors
Dose
500-3000 mg/day
Participants
Meta-analysis of 9 RCTs
Duration
4-24 weeks
Results
Significant reductions in total cholesterol (MD -18.3 mg/dL), LDL (MD -12.1 mg/dL), and triglycerides. HDL increased. Consistent across studies.
How They Measured It
Lipid profile, CRP, blood pressure across 9 RCTs
Blood Sugar Regulation
To evaluate amla fruit extract on glycaemic control in type 2 diabetes
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate amla fruit extract on glycaemic control in type 2 diabetes
Dose
1000 mg/day amla extract
Participants
80 type 2 diabetes patients
Duration
12 weeks
Results
Significant reduction in fasting glucose (-16%) and HbA1c (-0.6%) vs placebo. HOMA-IR improved by 18%. Postprandial glucose also reduced significantly.
How They Measured It
Fasting glucose, HbA1c, HOMA-IR, insulin
To assess amla powder on glycaemic parameters in pre-diabetic adults
Study Type
Randomised, placebo-controlled
Purpose
To assess amla powder on glycaemic parameters in pre-diabetic adults
Dose
2000 mg/day amla powder
Participants
55 pre-diabetic adults
Duration
8 weeks
Results
Fasting glucose reduced by 11% and 2-hr glucose by 14% vs placebo. Progression to diabetes prevented in more amla participants.
How They Measured It
FPG, 2hr post-load glucose, insulin resistance
Antioxidant & Immune Function
To evaluate amla supplementation on antioxidant status and immune markers
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate amla supplementation on antioxidant status and immune markers
Dose
500 mg/day amla extract
Participants
45 healthy adults
Duration
8 weeks
Results
Significant increase in antioxidant capacity (TEAC +34%), SOD activity, and NK cell activity. T-lymphocyte proliferation improved by 27%.
How They Measured It
TEAC, SOD, catalase, lymphocyte proliferation, NK cell activity
To assess amla anti-inflammatory effects in rheumatoid arthritis patients
Study Type
Randomised, controlled trial
Purpose
To assess amla anti-inflammatory effects in rheumatoid arthritis patients
Dose
3000 mg/day amla powder
Participants
50 rheumatoid arthritis patients
Duration
12 weeks
Results
Significant reduction in ESR, CRP, and DAS28 scores vs control. Joint tenderness and swelling scores improved significantly.
How They Measured It
ESR, CRP, DAS28, RF titre
To evaluate amla extract on NAFLD and liver function
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate amla extract on NAFLD and liver function
Dose
500 mg/day amla extract
Participants
66 patients with NAFLD
Duration
6 months
Results
Significant reductions in ALT (24%), AST (18%), and liver fat score vs placebo. Liver stiffness reduced in 40% vs 15% placebo.
How They Measured It
ALT, AST, liver fat by ultrasound, fibroscan
Hair & Skin Health
To evaluate amla on hair growth and quality in alopecia
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate amla on hair growth and quality in alopecia
Dose
Topical amla oil + 500 mg oral amla extract
Participants
45 patients with mild alopecia
Duration
12 weeks
Results
Significant increase in hair density (p=0.01) and shaft diameter. Telogen/anagen ratio improved. Patient-reported hair loss reduced significantly.
How They Measured It
Hair density count, hair diameter, telogen ratio
To assess amla extract effects on skin aging markers
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To assess amla extract effects on skin aging markers
Dose
600 mg/day amla extract
Participants
47 women aged 35-65
Duration
12 weeks
Results
Significant improvements in skin elasticity (+14%), hydration, and reduction in wrinkle depth. Collagen synthesis markers increased.
How They Measured It
Cutometry, VISIA skin analysis, collagen density, skin elasticity
Clinical trials
To investigate the effects of Amla in safety and efficacy of a mobiderm compression bandage during intensive phase of decongestive therapy in patients with breast cancer-related lymphedema
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Amla in safety and efficacy of a mobiderm compression bandage during intensive phase of decongestive therapy in patients with breast cancer-related lymphedema
Dose
Amla (dose not specified)
Participants
Participants not specified
Duration
15 days
Results
The use of Mobiderm in multilayer compression bandaging shows benefit in lymphedema reduction and in alleviating functional symptoms/pain in patients with BRCL.
How They Measured It
See study for outcome measures
To investigate the effects of Amla in effects of 12 weeks of chromium, phyllanthus emblica fruit extract, and shilajit supplementation on markers of cardiometabolic health, fitness, and we
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Amla in effects of 12 weeks of chromium, phyllanthus emblica fruit extract, and shilajit supplementation on markers of cardiometabolic health, fitness, and we
Dose
500 mg
Participants
Participants not specified
Duration
12 weeks
Results
: The results suggest that PE and Cr with PE and SJ supplementation may enhance some exercise- and diet-induced changes in markers of health in overweight individuals with at least two risk factors to MetSyn. Registered clinical trial #NCT06641596.
How They Measured It
See study for outcome measures
To investigate the effects of Amla in phyllanthus emblica fruit extract alleviates halitosis and reduces the inflammatory response to oral bacteria.
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Amla in phyllanthus emblica fruit extract alleviates halitosis and reduces the inflammatory response to oral bacteria.
Dose
Amla (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
To assess the efficacy of Phyllanthus emblica extract in alleviating halitosis and reducing the inflammatory response to halitosis-related bacteria.
How They Measured It
See study for outcome measures
To investigate the effects of Amla in optimized multiherbal combination and in vivo anti-skin aging potential: a randomized double blind placebo controlled study.
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Amla in optimized multiherbal combination and in vivo anti-skin aging potential: a randomized double blind placebo controlled study.
Dose
Amla (dose not specified)
Participants
60 participants
Duration
Duration not specified
Results
tly improved skin hydration, elasticity and wrinkles were observed in the test group. In addition, significantly reduced wrinkles were observed after 60 days in both skin areas of the test group. The anti-skin aging emulsion containing this optimized combination exhibited good safety and performance. Ultimately, this product comprises an effective anti-skin aging formulation for applications.
How They Measured It
See study for outcome measures
To investigate the effects of Amla in the effects of add-on therapy of phyllanthus emblica (amla) on laboratory confirmed covid-19 cases: a randomized, double-blind, controlled trial.
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Amla in the effects of add-on therapy of phyllanthus emblica (amla) on laboratory confirmed covid-19 cases: a randomized, double-blind, controlled trial.
Dose
Amla (dose not specified)
Participants
19 participants
Duration
Duration not specified
Results
This randomized, double-blind, controlled trial (RCT) aimed to evaluate the effect of Phyllanthus Emblica (Amla) as an add-on therapy on COVID-19_ related biomarkers and clinical outcomes in COVID-19 patients.
How They Measured It
See study for outcome measures
To investigate the effects of Amla in the effect of an oral product containing amla fruit (phyllanthus emblica l.) on female androgenetic alopecia: a randomized controlled trial.
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Amla in the effect of an oral product containing amla fruit (phyllanthus emblica l.) on female androgenetic alopecia: a randomized controlled trial.
Dose
Amla (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
Amla (Phyllanthus emblica) fruit has been emphasized as a hair tonic in Traditional Persian Medicine (TPM) and recommended for hair loss orally and topically.
How They Measured It
See study for outcome measures
To investigate the effects of Amla in antibacterial and anti-inflammatory effects of a novel herb-mediated nanocomposite mouthwash in plaque-induced gingivitis: a randomized controlled tri
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Amla in antibacterial and anti-inflammatory effects of a novel herb-mediated nanocomposite mouthwash in plaque-induced gingivitis: a randomized controlled tri
Dose
Amla (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
sed, including mechanical and chemical ones. Amla or Indian gooseberry is a medicinal herb; its secondary metabolites, such as phenolic acid, flavonoids and terpenoids, can be used to preferentially reduce metal ions and form nanoparticles (NPs). Green synthesis with the use of the amla seed extract is a unique approach for the production of graphene oxide (GO)-silver (Ag) nanocomposite mouthwash.
How They Measured It
See study for outcome measures
To investigate the effects of Amla in effect of amla extract on body mass index, waist circumference, total body fat, visceral fat, skeletal muscle mass, body age, and related parameters:
Study Type
Randomized, double-blind, placebo-controlled
Purpose
To investigate the effects of Amla in effect of amla extract on body mass index, waist circumference, total body fat, visceral fat, skeletal muscle mass, body age, and related parameters:
Dose
Amla (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
The escalating prevalence and severity of obesity and its associated comorbidities globally necessitate effective interventions. This randomized open-label clinical study aims to assess the efficacy of amla (Emblica officinalis) extract AMX-160 in adult individuals with obesity.
How They Measured It
See study for outcome measures
Systematic reviews
To investigate the effects of Amla in leukoaraiosis severity and outcomes of endovascular thrombectomy for acute ischemic stroke: a systematic review and meta-analysis.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Amla in leukoaraiosis severity and outcomes of endovascular thrombectomy for acute ischemic stroke: a systematic review and meta-analysis.
Dose
Amla (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
Endovascular thrombectomy (EVT) is the standard of care for eligible patients with large vessel occlusion (LVO). Yet, little is known regarding the impact of leukoaraiosis (LA) on outcomes following EVT for LVO.
How They Measured It
See study for outcome measures
To investigate the effects of Amla in the impact of emblica officinalis (amla) on lipid profile, glucose, and c-reactive protein: a systematic review and meta-analysis of randomized contro
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Amla in the impact of emblica officinalis (amla) on lipid profile, glucose, and c-reactive protein: a systematic review and meta-analysis of randomized contro
Dose
Amla (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
Emblica Officinalis (Amla) is a plant often utilized in traditional medicine due to its purported anti-inflammatory, antioxidant, hypoglycemic, and hypolipidemic properties. However, current evidence regarding its potential for preventing and treating metabolic abnormalities associated with chronic diseases remains unclear.
How They Measured It
See study for outcome measures
To investigate the effects of Amla in the efficacy and safety of emblica officinalis aqueous fruit extract among adult patients with dyslipidemia: a systematic review and meta-analysis.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Amla in the efficacy and safety of emblica officinalis aqueous fruit extract among adult patients with dyslipidemia: a systematic review and meta-analysis.
Dose
Amla (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
Flavonoids from Emblica officinalis effectively reduced serum and tissue lipid levels through their inhibitory effect on the hepatic β-hydroxy-β-methylglutaryl coenzyme A reductase activity. This study aimed to determine the efficacy and safety of E. officinalis extract in adults with dyslipidemia.
How They Measured It
See study for outcome measures
To investigate the effects of Amla in clinical effects of emblica officinalis fruit consumption on cardiovascular disease risk factors: a systematic review and meta-analysis.
Study Type
Systematic review and meta-analysis
Purpose
To investigate the effects of Amla in clinical effects of emblica officinalis fruit consumption on cardiovascular disease risk factors: a systematic review and meta-analysis.
Dose
Amla (dose not specified)
Participants
Participants not specified
Duration
Duration not specified
Results
effect on cardiovascular disease (CVD) physiological risk factors in preliminary clinical intervention trials; however, questions remain regarding the overall effectiveness of EO on CVD risk. The purpose of this systematic review and meta-analysis is to: 1) systematically describe the clinical research examining EO; and 2) quantitatively assess the effects of EO on CVD physiological risk factors.
How They Measured It
See study for outcome measures
Frequently Asked Questions
Common questions about Amla research
There are currently 22 peer-reviewed studies on Amla (Phyllanthus emblica), involving 634 total participants. Research covers Cardiovascular & Cholesterol, Blood Sugar Regulation, Antioxidant & Immune Function and 3 more areas. The overall evidence strength is rated as Very Strong.
The evidence is currently rated as "Very Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (17 human studies), and reported outcomes.
Amla has been researched for: Cardiovascular & Cholesterol, Blood Sugar Regulation, Antioxidant & Immune Function, Hair & Skin Health, Clinical trials, Systematic reviews. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 17 out of 22 studies are human trials. Human trials carry more weight in our evidence scoring system.
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