Ubiquinol
Research reviewed: Up until 03/2026
Ubiquinol (Ubiquinol (reduced Coenzyme Q10)) is a dietary supplement with 8 published peer-reviewed studies involving 1,620 participants, researched for Cardiovascular Health, Energy & Fatigue, Fertility and 1 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Cardiovascular Health
StrongEnergy & Fatigue
StrongFertility
StrongAntioxidant Protection
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Cardiovascular Health
To evaluate ubiquinol supplementation on cardiac function and exercise capacity in heart failure patients.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate ubiquinol supplementation on cardiac function and exercise capacity in heart failure patients.
Dose
300 mg/day ubiquinol
Participants
80 patients with heart failure (NYHA II-III)
Duration
12 weeks
Results
Ubiquinol significantly improved LVEF, 6-minute walk distance, and NYHA functional class compared to placebo. BNP decreased significantly, indicating improved cardiac function.
How They Measured It
LVEF, 6-minute walk test, BNP, NYHA class
To compare bioavailability and plasma CoQ10 of ubiquinol versus ubiquinone.
Study Type
Randomised, double-blind, crossover
Purpose
To compare bioavailability and plasma CoQ10 of ubiquinol versus ubiquinone.
Dose
300 mg/day ubiquinol vs 300 mg/day ubiquinone
Participants
24 healthy adults
Duration
4 weeks per arm
Results
Ubiquinol supplementation produced significantly higher plasma CoQ10 levels (3.5-fold greater absorption) than equimolar ubiquinone. Ubiquinol represents the more bioavailable form of CoQ10.
How They Measured It
Plasma total CoQ10, plasma ubiquinol:ubiquinone ratio
Energy & Fatigue
To assess ubiquinol on fatigue and physical performance in statin-treated patients.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To assess ubiquinol on fatigue and physical performance in statin-treated patients.
Dose
200 mg/day ubiquinol
Participants
96 statin-treated patients with muscle fatigue complaints
Duration
8 weeks
Results
Ubiquinol supplementation significantly reduced fatigue scores and improved grip strength and walk distance in statin-treated patients with exercise intolerance. Plasma CoQ10 increased 3-fold.
How They Measured It
Fatigue VAS, grip strength, 6-minute walk test, plasma CoQ10
To evaluate ubiquinol supplementation on exercise capacity in older adults.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate ubiquinol supplementation on exercise capacity in older adults.
Dose
100 mg/day ubiquinol
Participants
78 trained older adults
Duration
6 weeks
Results
Ubiquinol significantly improved peak power output and VO2max compared to placebo. Fatigue questionnaire scores were significantly lower with ubiquinol, suggesting improved exercise performance and recovery.
How They Measured It
VO2max, anaerobic threshold, muscle strength, fatigue questionnaire
Fertility
To assess ubiquinol on sperm quality parameters in infertile men.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To assess ubiquinol on sperm quality parameters in infertile men.
Dose
200 mg/day ubiquinol
Participants
228 infertile men with idiopathic oligoasthenoteratozoospermia
Duration
26 weeks
Results
Ubiquinol significantly improved sperm concentration (+53%), total motility (+26%), and forward motility compared to placebo. Morphology also improved. Ubiquinol is a well-supported therapy for male factor infertility.
How They Measured It
Sperm concentration, motility, morphology, seminal plasma CoQ10
To evaluate ubiquinol on ovarian response and embryo quality in IVF patients with poor ovarian reserve.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate ubiquinol on ovarian response and embryo quality in IVF patients with poor ovarian reserve.
Dose
600 mg/day ubiquinol
Participants
186 women undergoing IVF with poor ovarian response
Duration
60 days pre-IVF cycle
Results
Ubiquinol pre-treatment significantly improved the number of mature oocytes retrieved, fertilisation rate, and embryo quality scores. Live birth rates were higher in the ubiquinol group.
How They Measured It
Number of oocytes retrieved, fertilisation rate, embryo quality score, live birth rate
Antioxidant Protection
To evaluate ubiquinol on oxidative stress markers in elderly subjects.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate ubiquinol on oxidative stress markers in elderly subjects.
Dose
150 mg/day ubiquinol
Participants
79 elderly adults
Duration
4 weeks
Results
Ubiquinol supplementation significantly raised plasma ubiquinol and total antioxidant capacity while reducing 8-isoprostane and MDA. Ubiquinol is the primary lipid-soluble antioxidant in cell membranes.
How They Measured It
Plasma ubiquinol, 8-isoprostane, MDA, total antioxidant capacity
To compare the antioxidant efficacy of ubiquinol versus ubiquinone in cell membrane models.
Study Type
In-vitro study
Purpose
To compare the antioxidant efficacy of ubiquinol versus ubiquinone in cell membrane models.
Dose
Various concentrations in cell culture
Participants
Human erythrocyte and hepatocyte cell models
Duration
N/A
Results
Ubiquinol directly quenched lipid peroxyl radicals in cell membranes with significantly greater potency than ubiquinone. Ubiquinol is the active antioxidant form of CoQ10 in biological membranes.
How They Measured It
Lipid peroxidation rates, ROS generation, membrane integrity under oxidative stress
Frequently Asked Questions
Common questions about Ubiquinol research
There are currently 10 peer-reviewed studies on Ubiquinol (Ubiquinol (reduced Coenzyme Q10)), involving 1,620 total participants. Research covers Cardiovascular health, Energy & fatigue, Fertility and 1 more areas. The overall evidence strength is rated as Very Strong.
The evidence is currently rated as "Very Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (7 human studies), and reported outcomes.
Ubiquinol has been researched for: Cardiovascular health, Energy & fatigue, Fertility, Antioxidant protection. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 7 out of 10 studies are human trials. Human trials carry more weight in our evidence scoring system.
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