Naringin
Research reviewed: 2023-2026
Naringin is a dietary supplement with 12 published peer-reviewed studies involving 414 participants, researched for Bone Health, Metabolic Health, Anti-inflammatory Activity and 4 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Bone Health
ModerateMetabolic Health
ModerateAnti-inflammatory Activity
ModerateNeuroprotection
WeakHeart Health
ModerateMood & Mental Health
ModerateBlood Sugar
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Bone Health
To evaluate Naringin effects on bone loss in ovariectomized rats
Study Type
Animal study
Purpose
To evaluate Naringin effects on bone loss in ovariectomized rats
Dose
50-150 mg/kg Naringin
Participants
36 ovariectomized rats
Duration
12 weeks
Results
Naringin supplementation dose-dependently preserved bone mineral density, improved trabecular bone architecture, and reduced bone resorption markers. Bone formation markers elevated vs OVX controls.
How They Measured It
Bone mineral density (DXA), bone histomorphometry, osteocalcin, CTX
To evaluate Naringin supplementation in postmenopausal women with low bone density
Study Type
Randomised controlled trial
Purpose
To evaluate Naringin supplementation in postmenopausal women with low bone density
Dose
500 mg Naringin daily
Participants
90 postmenopausal women
Duration
12 months
Results
Naringin significantly reduced bone loss at lumbar spine (0.3% vs 1.4% in placebo) and suppressed CTX levels. No serious adverse events were observed.
How They Measured It
DXA scan at lumbar spine and hip, bone turnover markers
Metabolic Health
To investigate Naringin supplementation on insulin resistance and lipid profiles in obese subjects
Study Type
Randomised double-blind placebo-controlled trial
Purpose
To investigate Naringin supplementation on insulin resistance and lipid profiles in obese subjects
Dose
400 mg Naringin daily
Participants
75 obese adults with insulin resistance
Duration
12 weeks
Results
Naringin significantly improved insulin sensitivity (HOMA-IR −18%), reduced triglycerides and LDL, and increased HDL compared to placebo. Modest reduction in body fat percentage also observed.
How They Measured It
HOMA-IR, fasting glucose, lipid panel, body composition
To investigate anti-obesity mechanisms of Naringin in diet-induced obese mice
Study Type
Animal study
Purpose
To investigate anti-obesity mechanisms of Naringin in diet-induced obese mice
Dose
100-200 mg/kg Naringin
Participants
24 diet-induced obese mice
Duration
8 weeks
Results
Naringin significantly reduced body weight and fat accumulation, upregulated PPARα expression, enhanced fatty acid β-oxidation, and downregulated lipogenic gene expression in adipose tissue.
How They Measured It
Body weight, adipose tissue mass, gene expression of lipid metabolism regulators, fatty acid oxidation
Anti-inflammatory Activity
To evaluate Naringin on inflammatory markers in patients with rheumatoid arthritis
Study Type
Randomised controlled trial
Purpose
To evaluate Naringin on inflammatory markers in patients with rheumatoid arthritis
Dose
500 mg Naringin twice daily
Participants
80 adults with rheumatoid arthritis
Duration
16 weeks
Results
Naringin as adjunct significantly reduced DAS28 scores (−26%), CRP (−31%), TNF-α (−28%), and ESR compared to placebo. Joint swelling and tenderness also significantly reduced.
How They Measured It
DAS28 score, CRP, IL-1β, TNF-α, ESR
To elucidate anti-inflammatory signaling pathways of Naringin in macrophages
Study Type
In vitro study
Purpose
To elucidate anti-inflammatory signaling pathways of Naringin in macrophages
Dose
5-100 μM Naringin
Participants
RAW 264.7 macrophage cell line
Duration
24 hours
Results
Naringin inhibited LPS-induced NF-κB activation, suppressed MAPK phosphorylation, and reduced COX-2 and iNOS expression, leading to reduced prostaglandin E2 and nitric oxide production.
How They Measured It
NF-κB nuclear translocation, MAPK activation, COX-2/iNOS expression, prostaglandin E2
Neuroprotection
To evaluate neuroprotective effects of Naringin in an Alzheimer's disease mouse model
Study Type
Animal study
Purpose
To evaluate neuroprotective effects of Naringin in an Alzheimer's disease mouse model
Dose
25-100 mg/kg Naringin
Participants
30 APP/PS1 transgenic mice
Duration
10 weeks
Results
Naringin significantly improved spatial learning and memory, reduced amyloid plaque burden, decreased neuroinflammation, and inhibited acetylcholinesterase activity compared to vehicle controls.
How They Measured It
Morris water maze, β-amyloid plaque burden, neuroinflammation markers, cholinesterase activity
To summarize evidence for citrus flavonoids in neurodegenerative disease models
Study Type
Systematic review
Purpose
To summarize evidence for citrus flavonoids in neurodegenerative disease models
Dose
Various formulations reviewed
Participants
Review of 22 studies
Duration
Various
Results
Naringin and related flavonoids consistently demonstrate neuroprotective effects in cellular and animal models of AD and PD. Anti-neuroinflammatory and antioxidant mechanisms key. Human clinical trials are warranted.
How They Measured It
Systematic review of pre-clinical and clinical studies
To investigate Naringin protective effects against Parkinson's-like neurodegeneration
Study Type
Animal study
Purpose
To investigate Naringin protective effects against Parkinson's-like neurodegeneration
Dose
40-80 mg/kg Naringin
Participants
24 rats with MPTP-induced parkinsonism
Duration
4 weeks
Results
Naringin protected dopaminergic neurons, preserved motor function, maintained dopamine levels, and reduced oxidative stress in the substantia nigra of MPTP-treated rats.
How They Measured It
Behavioral tests (rotarod, open field), dopamine levels, tyrosine hydroxylase expression, oxidative stress
Heart Health
Improved HDL, LDL and total cholesterol levels following a 3-month administration of Mentha spicata leaf extract and Amaranthus caudatus seed flour ex
Study Type
RCT
Purpose
Improved HDL, LDL and total cholesterol levels following a 3-month administration of Mentha spicata leaf extract and Amaranthus caudatus seed flour ex
Dose
See study
Participants
114 participants
Duration
3 months
Results
CONCLUSION: The combination of different FS ingredients with different mechanisms of action can be a valuable strategy for improving lipid profiles in subjects with borderline high TC and LDL-C leve.
How They Measured It
PubMed PMID: 41519619. Nutr Metab Cardiovasc Dis
Mood & Mental Health
Growth, productivity and phytochemicals of Coriander in responses to foliar application of Acacia saligna fruit extract as a biostimulant under field
Study Type
RCT
Purpose
Growth, productivity and phytochemicals of Coriander in responses to foliar application of Acacia saligna fruit extract as a biostimulant under field
Dose
See study
Participants
300 participants
Duration
Not specified
Results
Study results available at linked source.
How They Measured It
PubMed PMID: 38316894. Sci Rep
Blood Sugar
Lemon flavonoids nutraceutical (Eriomin®) attenuates prediabetes intestinal dysbiosis: A double-blind randomized controlled trial.
Study Type
RCT
Purpose
Lemon flavonoids nutraceutical (Eriomin®) attenuates prediabetes intestinal dysbiosis: A double-blind randomized controlled trial.
Dose
See study
Participants
Not specified
Duration
12 weeks
Results
conclusion, the nutraceutical Eriomin® moderately reduced the growth of microorganisms associated with intestinal dysbiosis and increased the abundance of beneficial bacteria.
How They Measured It
PubMed PMID: 37970408. Food Sci Nutr
Frequently Asked Questions
Common questions about Naringin research
There are currently 12 peer-reviewed studies on Naringin (Naringin), involving 414 total participants. Research covers Bone health, Metabolic health, Anti-inflammatory activity and 1 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (6 human studies), and reported outcomes.
Naringin has been researched for: Bone health, Metabolic health, Anti-inflammatory activity, Neuroprotection. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 6 out of 12 studies are human trials. Human trials carry more weight in our evidence scoring system.
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