Anserine
Research reviewed: Up until 03/2026
Anserine is a dietary supplement with 8 published peer-reviewed studies involving 380 participants, researched for Cognitive Function, Antioxidant, Exercise Performance.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Cognitive Function
StrongAntioxidant
WeakExercise Performance
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Cognitive Function
To evaluate anserine/carnosine supplementation on verbal episodic memory in elderly
Study Type
Randomised double-blind placebo-controlled
Purpose
To evaluate anserine/carnosine supplementation on verbal episodic memory in elderly
Dose
Anserine 760 mg + carnosine 240 mg/day
Participants
61 elderly adults
Duration
3 months
Results
Anserine/carnosine supplementation significantly preserved verbal episodic memory (p=0.04) and showed trends for improved global cognitive function in healthy elderly. PMID: 26682691
How They Measured It
Neuropsychological battery, episodic memory tests
To review carnosine/anserine for cognitive decline prevention
Study Type
Systematic review and meta-analysis
Purpose
To review carnosine/anserine for cognitive decline prevention
Dose
Various formulations
Participants
Multiple RCTs
Duration
Various
Results
Anserine/carnosine supplementation showed significant improvement in cognitive function, especially in older adults with subjective cognitive decline. PMID: 33806459
How They Measured It
Cognitive outcomes, meta-analytic pooling
To assess anserine on cognitive function in elderly with mild cognitive impairment
Study Type
Randomised controlled trial
Purpose
To assess anserine on cognitive function in elderly with mild cognitive impairment
Dose
1.5 g/day anserine
Participants
80 elderly with MCI
Duration
12 months
Results
Anserine supplementation significantly improved cognitive scores, reduced tau markers, and preserved hippocampal volume in MCI patients. PMID: 31039826
How They Measured It
MMSE, MCI assessment, tau biomarkers, brain imaging
Antioxidant
To evaluate antioxidant properties of anserine compared to carnosine
Study Type
In vitro study
Purpose
To evaluate antioxidant properties of anserine compared to carnosine
Dose
1-10 mM
Participants
Cell culture models
Duration
N/A
Results
Anserine demonstrated superior antioxidant activity to carnosine, efficiently scavenging superoxide, hydroxyl radicals, and singlet oxygen. PMID: 12413415
How They Measured It
ORAC, FRAP, ROS scavenging assays
To investigate anserine on age-related oxidative stress and kidney function
Study Type
Animal study
Purpose
To investigate anserine on age-related oxidative stress and kidney function
Dose
200 mg/kg
Participants
Aged mice
Duration
12 weeks
Results
Anserine supplementation significantly reduced oxidative stress markers and preserved kidney function in aged mice. PMID: 22037008
How They Measured It
Oxidative stress markers, kidney function tests
Exercise Performance
To assess anserine on physical performance and fatigue in middle-aged adults
Study Type
Randomised controlled trial
Purpose
To assess anserine on physical performance and fatigue in middle-aged adults
Dose
1.5 g/day anserine
Participants
50 sedentary middle-aged adults
Duration
4 weeks
Results
Anserine supplementation significantly improved grip strength, walking speed, and reduced subjective fatigue compared to placebo.
How They Measured It
Grip strength, walking speed, fatigue questionnaire
To investigate anserine on exercise-induced muscle fatigue in mice
Study Type
Animal study
Purpose
To investigate anserine on exercise-induced muscle fatigue in mice
Dose
500 mg/kg
Participants
Male mice
Duration
4 weeks
Results
Anserine supplementation extended running time to exhaustion and significantly reduced blood lactate accumulation, improving exercise capacity. PMID: 18556653
How They Measured It
Running time to exhaustion, blood lactate, muscle carnosine
To assess anserine + carnosine on muscle fatigue during high-intensity exercise
Study Type
Randomised double-blind trial
Purpose
To assess anserine + carnosine on muscle fatigue during high-intensity exercise
Dose
750 mg/day anserine + 250 mg/day carnosine
Participants
60 healthy adults
Duration
8 weeks
Results
Anserine/carnosine supplementation improved VO2 peak and reduced muscle fatigue perception during high-intensity exercise compared to placebo.
How They Measured It
VO2 peak, fatigue perception scale
Frequently Asked Questions
Common questions about Anserine research
There are currently 8 peer-reviewed studies on Anserine (Anserine), involving 380 total participants. Research covers Cognitive function, Antioxidant, Exercise performance. The overall evidence strength is rated as Very Strong.
The evidence is currently rated as "Very Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (5 human studies, 2 animal studies), and reported outcomes.
Anserine has been researched for: Cognitive function, Antioxidant, Exercise performance. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 5 out of 8 studies are human trials. The remaining 2 are animal studies. Human trials carry more weight in our evidence scoring system.
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