White Mulberry
Research reviewed: Up until 03/2026
White Mulberry (Morus alba) is a dietary supplement with 10 published peer-reviewed studies involving 520 participants, researched for Blood Sugar Control, Cholesterol Management, Antioxidant.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Blood Sugar Control
StrongCholesterol Management
ModerateAntioxidant
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Blood Sugar Control
To meta-analyze Morus alba for blood sugar management
Study Type
Systematic review and meta-analysis
Purpose
To meta-analyze Morus alba for blood sugar management
Dose
Various
Participants
Multiple RCTs
Duration
Various
Results
White mulberry significantly reduced fasting and postprandial glucose across multiple clinical trials. DNJ (1-deoxynojirimycin) identified as primary active compound inhibiting alpha-glucosidase. PMCID: PMC9152381
How They Measured It
Fasting glucose, postprandial glucose, HbA1c, pooled analysis
To assess Morus alba leaf extract on metabolic profiles in type 2 diabetes
Study Type
Randomised double-blind placebo-controlled
Purpose
To assess Morus alba leaf extract on metabolic profiles in type 2 diabetes
Dose
1000 mg/day Morus alba extract
Participants
68 type 2 diabetic patients
Duration
12 weeks
Results
Morus alba extract significantly improved HDL-C and insulin levels and reduced MDA oxidative stress marker in type 2 diabetics. PMID: 35623877
How They Measured It
HbA1c, insulin, HDL-C, MDA, metabolic profiles
To compare Morus alba tablet vs glibenclamide for blood glucose in type 2 diabetes
Study Type
Randomised controlled trial
Purpose
To compare Morus alba tablet vs glibenclamide for blood glucose in type 2 diabetes
Dose
3 tablets/day (equivalent to 1g mulberry)
Participants
40 type 2 diabetics
Duration
4 weeks
Results
Mulberry tablet produced significant glucose reduction comparable to glibenclamide. Traditional glucose-lowering use supported by clinical data.
How They Measured It
Fasting glucose, postprandial glucose, HbA1c
To review phytochemistry, pharmacology, and clinical trials of Morus alba
Study Type
Review
Purpose
To review phytochemistry, pharmacology, and clinical trials of Morus alba
Dose
Various
Participants
N/A
Duration
N/A
Results
Clinical trials confirmed Morus alba reduces blood glucose and cholesterol and enhances cognitive ability. Rich phytochemical profile includes flavonoids, alkaloids, and stilbenes. PMID: 26850343
How They Measured It
Clinical trial evidence review for multiple indications
Cholesterol Management
To investigate White mulberry tea on lipid metabolism in type 2 diabetes rat model
Study Type
Animal study
Purpose
To investigate White mulberry tea on lipid metabolism in type 2 diabetes rat model
Dose
Mulberry leaf tea ad libitum
Participants
Diabetic rats
Duration
4 weeks
Results
Mulberry leaf tea significantly reduced total cholesterol, LDL-C, and triglycerides in diabetic rats. Hepatic lipid enzyme activity modulated. PMID: 25850211
How They Measured It
Total cholesterol, LDL-C, triglycerides, liver lipid enzymes
To assess White mulberry on LDL-C and cardiovascular risk factors
Study Type
Randomised controlled trial
Purpose
To assess White mulberry on LDL-C and cardiovascular risk factors
Dose
3 g/day mulberry leaf powder
Participants
45 adults with mild hyperlipidaemia
Duration
12 weeks
Results
White mulberry significantly reduced LDL-C and total cholesterol while maintaining HDL-C levels. Inflammatory marker hs-CRP also reduced. PMID: 20578839
How They Measured It
Total cholesterol, LDL-C, HDL-C, triglycerides, hs-CRP
To investigate mulberry leaf hypoglycaemic mechanisms and lipid effects
Study Type
Animal study
Purpose
To investigate mulberry leaf hypoglycaemic mechanisms and lipid effects
Dose
Various concentrations mulberry extract
Participants
HepG2 liver cells and T2DM rats
Duration
N/A and 4 weeks
Results
Mulberry leaf significantly inhibited alpha-glucosidase, activated AMPK, and reduced hepatic lipid synthesis. Multiple synergistic mechanisms for glucose and lipid lowering confirmed. PMCID: PMC10117911
How They Measured It
Alpha-glucosidase inhibition, AMPK activation, lipid metabolism
Antioxidant
To assess White mulberry extract on oxidative stress and inflammation in T2DM
Study Type
Randomised controlled trial
Purpose
To assess White mulberry extract on oxidative stress and inflammation in T2DM
Dose
1000 mg/day White mulberry extract
Participants
50 type 2 diabetic patients
Duration
8 weeks
Results
White mulberry extract significantly reduced MDA lipid peroxidation and inflammatory markers while improving antioxidant enzyme activities in diabetic patients.
How They Measured It
MDA, SOD, CAT, hs-CRP, IL-6
To characterize antioxidant and anti-inflammatory properties of mulberry leaf compounds
Study Type
In vitro study
Purpose
To characterize antioxidant and anti-inflammatory properties of mulberry leaf compounds
Dose
Various concentrations
Participants
Cell-free antioxidant assays and LPS-stimulated macrophages
Duration
N/A
Results
Mulberry leaf compounds (rutin, quercetin, chlorogenic acid) demonstrated potent antioxidant and anti-inflammatory activities, inhibiting COX-2 and NF-kB in macrophages.
How They Measured It
DPPH scavenging, ABTS, anti-inflammatory assays
To assess White mulberry on oxidative stress and non-alcoholic fatty liver disease
Study Type
Animal study
Purpose
To assess White mulberry on oxidative stress and non-alcoholic fatty liver disease
Dose
400 mg/kg mulberry extract
Participants
Obese mice
Duration
8 weeks
Results
White mulberry extract significantly reduced hepatic fat accumulation, liver enzymes, and oxidative stress in obese mice, demonstrating hepatoprotective and antioxidant effects.
How They Measured It
Liver enzymes, oxidative stress, liver histology, fat accumulation
Frequently Asked Questions
Common questions about White Mulberry research
There are currently 10 peer-reviewed studies on White Mulberry (Morus alba), involving 520 total participants. Research covers Blood sugar control, Cholesterol management, Antioxidant. The overall evidence strength is rated as Very Strong.
The evidence is currently rated as "Very Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (6 human studies, 3 animal studies), and reported outcomes.
White Mulberry has been researched for: Blood sugar control, Cholesterol management, Antioxidant. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 6 out of 10 studies are human trials. The remaining 3 are animal studies. Human trials carry more weight in our evidence scoring system.
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