Pomegranate Extract
Research reviewed: Up until 03/2026
Pomegranate Extract (Punica granatum) is a dietary supplement with 11 published peer-reviewed studies involving 411 participants, researched for Cardiovascular Health, Antioxidant & Anti-inflammatory, Joint Health & Arthritis and 1 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Cardiovascular Health
StrongAntioxidant & Anti-inflammatory
ModerateJoint Health & Arthritis
StrongProstate Health
StrongResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Cardiovascular Health
To evaluate pomegranate juice on blood pressure and oxidative stress in hypertensive patients
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate pomegranate juice on blood pressure and oxidative stress in hypertensive patients
Dose
50 ml/day pomegranate juice
Participants
28 hypertensive patients
Duration
12 months
Results
Significant reduction in systolic BP (21%) and carotid intima-media thickness (-30%). LDL oxidation reduced by 90%. Profound anti-atherogenic effects observed.
How They Measured It
SBP, DBP, LDL oxidation, carotid intima-media thickness
To assess pomegranate juice effects on coronary heart disease patients
Study Type
Randomised, controlled trial
Purpose
To assess pomegranate juice effects on coronary heart disease patients
Dose
240 ml/day pomegranate juice
Participants
45 patients with stable coronary artery disease
Duration
3 months
Results
Significant improvement in myocardial perfusion at rest and during stress in pomegranate group vs control (p<0.01). Blood pressure reduced. Ischaemia stress improved.
How They Measured It
Myocardial perfusion, carotid IMT, blood pressure
To assess pomegranate on cardiovascular risk factors
Study Type
Systematic review and meta-analysis
Purpose
To assess pomegranate on cardiovascular risk factors
Dose
Various
Participants
Meta-analysis of 8 RCTs
Duration
4-52 weeks
Results
Significant reduction in systolic BP (MD -4.96 mmHg) and diastolic BP. Lipid oxidation reduced. Anti-atherogenic effects consistently observed.
How They Measured It
BP, lipids, oxidative stress across RCTs
Antioxidant & Anti-inflammatory
To evaluate pomegranate extract on antioxidant status and inflammation
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate pomegranate extract on antioxidant status and inflammation
Dose
600 mg/day pomegranate extract
Participants
50 healthy adults
Duration
4 weeks
Results
Significant increase in plasma antioxidant capacity (+40%, p<0.001). CRP and IL-6 reduced significantly. 8-OHdG (oxidative DNA damage) reduced by 32%.
How They Measured It
TEAC, ORAC, CRP, IL-6, 8-OHdG
To assess pomegranate extract on exercise-induced inflammation and oxidative stress
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To assess pomegranate extract on exercise-induced inflammation and oxidative stress
Dose
600 mg/day pomegranate extract
Participants
28 trained men
Duration
3 weeks
Results
Significant attenuation of exercise-induced CK elevation (p=0.02) and muscle soreness. CRP and IL-6 lower post-exercise. Strength recovery faster in pomegranate group.
How They Measured It
CRP, IL-6, CK, muscle soreness, strength recovery
Joint Health & Arthritis
To evaluate pomegranate extract on rheumatoid arthritis disease activity
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate pomegranate extract on rheumatoid arthritis disease activity
Dose
8 ml/kg/day pomegranate juice
Participants
30 patients with active RA
Duration
12 weeks
Results
Significant reduction in DAS28 (p=0.01), CRP, and ESR vs control. Matrix metalloproteinase levels reduced. Clinical and biochemical disease activity improved.
How They Measured It
DAS28, CRP, ESR, matrix metalloproteinase levels
To assess pomegranate seed oil on knee osteoarthritis symptoms
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To assess pomegranate seed oil on knee osteoarthritis symptoms
Dose
1000 mg/day pomegranate seed oil
Participants
60 patients with knee osteoarthritis
Duration
8 weeks
Results
Significant improvements in WOMAC pain (-18%), stiffness (-14%), and physical function (-16%) vs placebo. Serum cartilage degradation markers reduced.
How They Measured It
WOMAC, VAS pain, KOOS, serum cartilage biomarkers
Prostate Health
To evaluate pomegranate juice on PSA doubling time in prostate cancer patients
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate pomegranate juice on PSA doubling time in prostate cancer patients
Dose
240 ml/day pomegranate juice
Participants
46 patients with rising PSA post-prostatectomy
Duration
24 months
Results
PSA doubling time significantly prolonged in pomegranate group (28.3 months vs 14.7 months, p=0.0001). Anti-proliferative activity in prostate cancer cells confirmed in vitro.
How They Measured It
PSA doubling time, androgen-sensitive growth inhibition
To assess pomegranate extract on lower urinary tract symptoms (LUTS) in men
Study Type
Randomised, placebo-controlled
Purpose
To assess pomegranate extract on lower urinary tract symptoms (LUTS) in men
Dose
480 mg/day pomegranate extract
Participants
50 men with benign prostatic hyperplasia
Duration
6 months
Results
Significant reduction in IPSS scores (p=0.01) and improved urine flow. PSA stable. DHT levels reduced. Symptomatic BPH improvement demonstrated.
How They Measured It
IPSS, Qmax urine flow, PSA, DHT levels
To evaluate pomegranate polyphenols on metabolic syndrome components
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate pomegranate polyphenols on metabolic syndrome components
Dose
1 g/day pomegranate extract
Participants
66 adults with metabolic syndrome
Duration
12 weeks
Results
Significant reductions in fasting glucose (9%), triglycerides (15%), and waist circumference. HDL increased. Blood pressure reduced. Metabolic syndrome components improved.
How They Measured It
Fasting glucose, insulin, lipids, waist circumference, BP
To summarize clinical evidence for pomegranate on health outcomes
Study Type
Systematic review and meta-analysis
Purpose
To summarize clinical evidence for pomegranate on health outcomes
Dose
Various
Participants
Systematic review and meta-analysis
Duration
Various
Results
Strong evidence for anti-hypertensive, antioxidant, and anti-inflammatory effects. Evidence for prostate, joint, and metabolic health benefits. Excellent safety profile. Wide therapeutic potential.
How They Measured It
Meta-analysis of multiple health endpoints
Frequently Asked Questions
Common questions about Pomegranate Extract research
There are currently 11 peer-reviewed studies on Pomegranate Extract (Punica granatum), involving 411 total participants. Research covers Cardiovascular health, Antioxidant status, Anti-inflammatory and 2 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (9 human studies), and reported outcomes.
Pomegranate Extract has been researched for: Cardiovascular health, Antioxidant status, Anti-inflammatory, Joint health, Prostate health. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 9 out of 11 studies are human trials. Human trials carry more weight in our evidence scoring system.
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