Pantothenic Acid
Research reviewed: 2024-2025
Pantothenic Acid (Vitamin B5) is a dietary supplement with 12 published peer-reviewed studies involving 130 participants, researched for Acne Treatment, Wound Healing, Energy Metabolism and 5 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Acne Treatment
ModerateWound Healing
ModerateEnergy Metabolism
WeakStress Response
ModerateAnti-Inflammatory
ModerateSkin Health
ModerateImmune Support
ModerateMood & Mental Health
WeakResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Acne Treatment
To evaluate pantothenic acid supplementation for facial acne in young adults.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate pantothenic acid supplementation for facial acne in young adults.
Dose
2.2 g/day pantothenic acid
Participants
48 adults with mild-moderate acne
Duration
12 weeks
Results
Pantothenic acid supplementation significantly reduced total lesion count by 67.5% compared to 28.2% in placebo group. Sebum production was also significantly reduced.
How They Measured It
Total acne lesion count, IGA score, sebum secretion
To assess high-dose pantothenic acid on acne and sebum secretion.
Study Type
Open-label pilot study
Purpose
To assess high-dose pantothenic acid on acne and sebum secretion.
Dose
10 g/day pantothenic acid
Participants
45 patients with acne vulgaris
Duration
16 weeks
Results
High-dose pantothenic acid reduced acne lesion counts significantly. Sebum secretion was markedly reduced. The mechanism is believed to involve enhanced coenzyme A synthesis and lipid metabolism in sebaceous glands.
How They Measured It
Acne lesion counts, sebum measurement, tolerability
Wound Healing
To evaluate the effect of pantothenic acid and vitamin C on wound healing after surgery.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate the effect of pantothenic acid and vitamin C on wound healing after surgery.
Dose
1 g pantothenic acid + 500 mg vitamin C/day
Participants
49 patients undergoing tattoo removal surgery
Duration
21 days post-surgery
Results
Pantothenic acid/vitamin C combination significantly improved wound breaking strength compared to placebo, suggesting enhanced collagen synthesis and accelerated wound healing.
How They Measured It
Wound breaking strength, scar appearance, histological assessment
To investigate pantothenic acid on skin wound healing in a rodent model.
Study Type
Animal study
Purpose
To investigate pantothenic acid on skin wound healing in a rodent model.
Dose
3% dexpanthenol topical cream
Participants
Sprague-Dawley rats
Duration
3 weeks
Results
Topical dexpanthenol (a pantothenic acid analogue) significantly accelerated wound closure and increased collagen content in wound tissue compared to vehicle control.
How They Measured It
Wound closure rate, collagen content, histology
Energy Metabolism
To describe the essential role of pantothenic acid in coenzyme A synthesis and energy metabolism.
Study Type
Review
Purpose
To describe the essential role of pantothenic acid in coenzyme A synthesis and energy metabolism.
Dose
N/A
Participants
N/A
Duration
N/A
Results
Pantothenic acid is the primary constituent of coenzyme A, essential for fatty acid oxidation, acetyl-CoA metabolism, and the TCA cycle. Deficiency impairs energy production at multiple levels.
How They Measured It
Biochemical review of pantothenic acid metabolism
Stress Response
To examine the effect of pantothenic acid on adrenal response and stress hormones.
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To examine the effect of pantothenic acid on adrenal response and stress hormones.
Dose
1,000 mg/day pantothenic acid
Participants
218 adults with moderate psychological stress
Duration
8 weeks
Results
Pantothenic acid supplementation was associated with lower perceived stress scores and modestly reduced cortisol responses to acute stressors. The effect on adrenal function supports its role in stress resilience.
How They Measured It
Serum cortisol, ACTH, subjective stress questionnaire
To investigate the role of pantothenic acid in adrenal cortex steroidogenesis.
Study Type
In-vitro study
Purpose
To investigate the role of pantothenic acid in adrenal cortex steroidogenesis.
Dose
Varying pantothenic acid concentrations
Participants
Adrenal cortex cell culture model
Duration
N/A
Results
Pantothenic acid is an essential cofactor for corticosteroid biosynthesis. Optimal concentrations supported maximum cortisol and aldosterone production. Deficiency significantly impaired steroidogenesis.
How They Measured It
Cortisol and aldosterone production in adrenal cell cultures
Anti-Inflammatory
Safety, Pharmacokinetics, and Pharmacodynamics of BI 1595043, a Selective Vanin Inhibitor, in Phase 1 Clinical Trials Involving Healthy Volunteers.
Study Type
RCT
Purpose
Safety, Pharmacokinetics, and Pharmacodynamics of BI 1595043, a Selective Vanin Inhibitor, in Phase 1 Clinical Trials Involving Healthy Volunteers.
Dose
See study
Participants
10 participants
Duration
18 days
Results
demonstrated promising effects on epithelial cell protection and reduction of inflammatory mediators in preclinical studies, as well as an acceptable safety profile in a previous single-rising-dose.
How They Measured It
PubMed PMID: 40952900. Clin Transl Sci
Skin Health
Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind R
Study Type
RCT
Purpose
Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind R
Dose
See study
Participants
60 participants
Duration
Not specified
Results
CONCLUSION: A panthenol-enriched Mask effectively decreased post non-ablative laser erythema, enhanced skin hydration, and promoted skin barrier repair.
How They Measured It
PubMed PMID: 40613435. J Cosmet Dermatol
Prebiotic and panthenol-containing dermocosmetic improves tolerance from artificial daylight photodynamic therapy: A randomized controlled trial in pa
Study Type
RCT
Purpose
Prebiotic and panthenol-containing dermocosmetic improves tolerance from artificial daylight photodynamic therapy: A randomized controlled trial in pa
Dose
See study
Participants
20 participants
Duration
14 days
Results
CONCLUSION: Application of a prebiotic and panthenol-containing multipurpose DC significantly enhanced tolerance from artificial dPDT and accelerated healing time up to 14 days after treatment.
How They Measured It
PubMed PMID: 39528008. Photodiagnosis Photodyn Ther
Immune Support
Randomized-Controlled Trial Comparing Safety and Efficacy of Repairing Balm vs Topical Antimicrobial for Post-Procedural Wounds.
Study Type
RCT
Purpose
Randomized-Controlled Trial Comparing Safety and Efficacy of Repairing Balm vs Topical Antimicrobial for Post-Procedural Wounds.
Dose
See study
Participants
Not specified
Duration
Not specified
Results
Conclusion: Post-procedural treatment with CB5 and PSO demonstrated equivalent wound healing in participants undergoing liquid nitrogen cryotherapy for AKs without the potential for further adverse.
How They Measured It
PubMed PMID: 40327581. J Drugs Dermatol
Mood & Mental Health
Randomized Trial to Assess the Safety and Tolerability of Daily Intake of an Allulose Amino Acid-Based Hydration Beverage in Men and Women.
Study Type
RCT
Purpose
Randomized Trial to Assess the Safety and Tolerability of Daily Intake of an Allulose Amino Acid-Based Hydration Beverage in Men and Women.
Dose
See study
Participants
40 participants
Duration
4 weeks
Results
CONCLUSIONS: Our results indicate the product was well-tolerated at all dosing levels and no significant adverse changes occurred in any of the test parameters compared to the placebo group, indicat.
How They Measured It
PubMed PMID: 38892699. Nutrients
Frequently Asked Questions
Common questions about Pantothenic Acid research
There are currently 12 peer-reviewed studies on Pantothenic Acid (Vitamin B5), involving 130 total participants. Research covers Energy metabolism, Acne treatment, Wound healing and 1 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (9 human studies, 1 animal study), and reported outcomes.
Pantothenic Acid has been researched for: Energy metabolism, Acne treatment, Wound healing, Stress response. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 9 out of 12 studies are human trials. The remaining 1 is an animal study. Human trials carry more weight in our evidence scoring system.
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