Myo-Inositol
Research reviewed: 2025-2026
Myo-Inositol is a dietary supplement with 18 published peer-reviewed studies involving 506 participants, researched for PCOS Management, Insulin Sensitivity, Mental Health and 4 more areas.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
PCOS Management
ModerateInsulin Sensitivity
StrongMental Health
StrongBlood Sugar
ModerateGeneral Health
ModerateCognitive Function
ModerateHeart Health
ModerateResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
PCOS Management
To assess the effects of myo-inositol in women with PCOS via meta-analysis of RCTs
Study Type
Systematic review and meta-analysis
Purpose
To assess the effects of myo-inositol in women with PCOS via meta-analysis of RCTs
Dose
Various
Participants
247 cases, 249 controls across 9 RCTs
Duration
Various
Results
Myo-inositol significantly decreased fasting insulin (p=0.009) and HOMA-IR (p=0.041) in PCOS women.
How They Measured It
Insulin, HOMA-IR, testosterone, FSH, LH, BMI
To evaluate efficacy of myo-inositol on anthropometric, metabolic, and endocrine outcomes in PCOS
Study Type
Meta-analysis of randomised controlled trials
Purpose
To evaluate efficacy of myo-inositol on anthropometric, metabolic, and endocrine outcomes in PCOS
Dose
Various
Participants
Multiple trials pooled
Duration
Various
Results
Myo-inositol significantly improved BMI, testosterone levels, insulin resistance, and hormonal profile in PCOS.
How They Measured It
BMI, testosterone, FSH, HOMA-IR, AMH
To evaluate myo-inositol on menstrual regularity and hormonal balance in PCOS
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate myo-inositol on menstrual regularity and hormonal balance in PCOS
Dose
4 g/day myo-inositol + 400 ug folic acid
Participants
50 PCOS women
Duration
12 weeks
Results
86% of myo-inositol group restored regular menstruation vs 12% placebo; normalised hormonal profiles.
How They Measured It
Menstrual cycle regularity, testosterone, FSH, LH, ovulation rate
To compare myo-inositol with metformin on metabolic outcomes in PCOS
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To compare myo-inositol with metformin on metabolic outcomes in PCOS
Dose
4 g/day myo-inositol
Participants
92 PCOS women
Duration
14 weeks
Results
Myo-inositol was as effective as metformin in reducing insulin resistance and androgen levels in PCOS.
How They Measured It
BMI, insulin resistance, androgens, lipid profile
To compare myoinositol with metformin vs metformin monotherapy in PCOS
Study Type
Randomised controlled trial
Purpose
To compare myoinositol with metformin vs metformin monotherapy in PCOS
Dose
4 g myo-inositol + 400 mg d-chiro-inositol combined with metformin
Participants
60 PCOS women
Duration
6 months
Results
Combination therapy showed superior metabolic and hormonal improvements vs metformin alone.
How They Measured It
Metabolic parameters, hormone levels, ovulation
Insulin Sensitivity
To evaluate myo-inositol supplementation in gestational diabetes prevention
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate myo-inositol supplementation in gestational diabetes prevention
Dose
4 g/day myo-inositol + 400 ug folic acid
Participants
220 overweight pregnant women
Duration
From first trimester
Results
Myo-inositol significantly reduced gestational diabetes incidence (6% vs 15.3% placebo, p=0.04).
How They Measured It
Gestational diabetes incidence, fasting glucose, insulin
To assess myo-inositol effect on insulin resistance in metabolic syndrome
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To assess myo-inositol effect on insulin resistance in metabolic syndrome
Dose
2 g twice daily
Participants
80 metabolic syndrome patients
Duration
6 months
Results
Myo-inositol significantly reduced insulin resistance, blood pressure, and triglycerides vs placebo.
How They Measured It
HOMA-IR, fasting insulin, postprandial glucose
To evaluate myo-inositol for insulin resistance, metabolic syndrome, PCOS, and gestational diabetes
Study Type
Randomised, controlled trial
Purpose
To evaluate myo-inositol for insulin resistance, metabolic syndrome, PCOS, and gestational diabetes
Dose
2-4 g/day
Participants
Multiple cohorts
Duration
Various
Results
Myo-inositol consistently improved insulin sensitivity across multiple metabolic conditions.
How They Measured It
Insulin sensitivity, HOMA-IR, glucose tolerance
Mental Health
To evaluate high-dose inositol supplementation for panic disorder
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate high-dose inositol supplementation for panic disorder
Dose
18 g/day myo-inositol
Participants
21 panic disorder patients
Duration
4 weeks
Results
Myo-inositol significantly reduced frequency and severity of panic attacks vs placebo (p<0.05).
How They Measured It
Panic attack frequency, Hamilton Anxiety Rating Scale
To evaluate inositol supplementation for depression
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate inositol supplementation for depression
Dose
12 g/day myo-inositol
Participants
28 depressed patients
Duration
4 weeks
Results
Myo-inositol supplementation significantly reduced HDRS scores vs placebo (p<0.05).
How They Measured It
Hamilton Depression Rating Scale (HDRS)
To assess myo-inositol effect on obsessive-compulsive disorder symptoms
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To assess myo-inositol effect on obsessive-compulsive disorder symptoms
Dose
18 g/day myo-inositol
Participants
13 OCD patients
Duration
6 weeks
Results
Myo-inositol significantly reduced Y-BOCS scores vs placebo in OCD patients.
How They Measured It
Yale-Brown OCD Scale (Y-BOCS)
To compare myo-inositol with fluvoxamine in the treatment of panic disorder
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To compare myo-inositol with fluvoxamine in the treatment of panic disorder
Dose
18 g/day myo-inositol
Participants
20 panic disorder patients
Duration
1 month per treatment (crossover)
Results
Myo-inositol reduced panic attacks as effectively as fluvoxamine with fewer side effects.
How They Measured It
Panic attack frequency, anxiety scales
To assess myo-inositol supplementation for anxiety in women with PCOS
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To assess myo-inositol supplementation for anxiety in women with PCOS
Dose
4 g/day myo-inositol
Participants
46 PCOS women
Duration
12 weeks
Results
Myo-inositol significantly reduced anxiety and depression scores vs placebo in PCOS women.
How They Measured It
State-Trait Anxiety Inventory (STAI), depression scale
Blood Sugar
Effect of Myo-Inositol Treatment on Serum Asprosin Levels of Pregnant Women: A Prospective Randomized Controlled Pilot Study.
Study Type
RCT
Purpose
Effect of Myo-Inositol Treatment on Serum Asprosin Levels of Pregnant Women: A Prospective Randomized Controlled Pilot Study.
Dose
See study
Participants
40 participants
Duration
22 weeks
Results
CONCLUSIONS: Asprosin may be modulated by myo-inositol.
How They Measured It
PubMed PMID: 41497562. J Pregnancy
General Health
Expression of Concern on "Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controll
Study Type
RCT
Purpose
Expression of Concern on "Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controll
Dose
See study
Participants
Not specified
Duration
Not specified
Results
Study results available at linked source.
How They Measured It
PubMed PMID: 41489236. Eur Rev Med Pharmacol Sci
Cognitive Function
Nutritional supplements to improve esports player performance: a systematic review of randomized controlled trials.
Study Type
Meta-Analysis
Purpose
Nutritional supplements to improve esports player performance: a systematic review of randomized controlled trials.
Dose
See study
Participants
466 participants
Duration
Not specified
Results
CONCLUSION: Specific nutritional supplements may improve esports players' cognitive function, psychological mood, and gaming performance.
How They Measured It
PubMed PMID: 41424341. J Int Soc Sports Nutr
Beyond Inflammation: Why Understanding the Brain Matters in Inflammatory Arthritis.
Study Type
RCT
Purpose
Beyond Inflammation: Why Understanding the Brain Matters in Inflammatory Arthritis.
Dose
See study
Participants
Not specified
Duration
Not specified
Results
Study results available at linked source.
How They Measured It
PubMed PMID: 41236146. Arthritis Care Res (Hoboken)
Heart Health
Effect of Insulin Sensitizers on Glycemic and Lipid Profile in Patients with Polycystic Ovary Syndrome (PCOS).
Study Type
RCT
Purpose
Effect of Insulin Sensitizers on Glycemic and Lipid Profile in Patients with Polycystic Ovary Syndrome (PCOS).
Dose
See study
Participants
Not specified
Duration
6 months
Results
Conclusion: Myoinositol improved cholesterol in PCOS patients regardless of BMI.
How They Measured It
PubMed PMID: 41363914. Pril (Makedon Akad Nauk Umet Odd Med Nauki)
Frequently Asked Questions
Common questions about Myo-Inositol research
There are currently 18 peer-reviewed studies on Myo-Inositol (Myo-Inositol), involving 506 total participants. Research covers PCOS management, Insulin sensitivity, Mental health. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (15 human studies), and reported outcomes.
Myo-Inositol has been researched for: PCOS management, Insulin sensitivity, Mental health. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 15 out of 18 studies are human trials. Human trials carry more weight in our evidence scoring system.
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