Myo-Inositol
Research reviewed: Up until 03/2026
Myo-Inositol is a dietary supplement with 13 published peer-reviewed studies involving 920 participants, researched for PCOS Management, Insulin Sensitivity, Mental Health.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
PCOS Management
StrongInsulin Sensitivity
StrongMental Health
StrongResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
PCOS Management
To assess the effects of myo-inositol in women with PCOS via meta-analysis of RCTs
Study Type
Systematic review and meta-analysis
Purpose
To assess the effects of myo-inositol in women with PCOS via meta-analysis of RCTs
Dose
Various
Participants
247 cases, 249 controls across 9 RCTs
Duration
Various
Results
Myo-inositol significantly decreased fasting insulin (p=0.009) and HOMA-IR (p=0.041) in PCOS women.
How They Measured It
Insulin, HOMA-IR, testosterone, FSH, LH, BMI
To evaluate efficacy of myo-inositol on anthropometric, metabolic, and endocrine outcomes in PCOS
Study Type
Meta-analysis of randomised controlled trials
Purpose
To evaluate efficacy of myo-inositol on anthropometric, metabolic, and endocrine outcomes in PCOS
Dose
Various
Participants
Multiple trials pooled
Duration
Various
Results
Myo-inositol significantly improved BMI, testosterone levels, insulin resistance, and hormonal profile in PCOS.
How They Measured It
BMI, testosterone, FSH, HOMA-IR, AMH
To evaluate myo-inositol on menstrual regularity and hormonal balance in PCOS
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate myo-inositol on menstrual regularity and hormonal balance in PCOS
Dose
4 g/day myo-inositol + 400 ug folic acid
Participants
50 PCOS women
Duration
12 weeks
Results
86% of myo-inositol group restored regular menstruation vs 12% placebo; normalised hormonal profiles.
How They Measured It
Menstrual cycle regularity, testosterone, FSH, LH, ovulation rate
To compare myo-inositol with metformin on metabolic outcomes in PCOS
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To compare myo-inositol with metformin on metabolic outcomes in PCOS
Dose
4 g/day myo-inositol
Participants
92 PCOS women
Duration
14 weeks
Results
Myo-inositol was as effective as metformin in reducing insulin resistance and androgen levels in PCOS.
How They Measured It
BMI, insulin resistance, androgens, lipid profile
To compare myoinositol with metformin vs metformin monotherapy in PCOS
Study Type
Randomised controlled trial
Purpose
To compare myoinositol with metformin vs metformin monotherapy in PCOS
Dose
4 g myo-inositol + 400 mg d-chiro-inositol combined with metformin
Participants
60 PCOS women
Duration
6 months
Results
Combination therapy showed superior metabolic and hormonal improvements vs metformin alone.
How They Measured It
Metabolic parameters, hormone levels, ovulation
Insulin Sensitivity
To evaluate myo-inositol supplementation in gestational diabetes prevention
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate myo-inositol supplementation in gestational diabetes prevention
Dose
4 g/day myo-inositol + 400 ug folic acid
Participants
220 overweight pregnant women
Duration
From first trimester
Results
Myo-inositol significantly reduced gestational diabetes incidence (6% vs 15.3% placebo, p=0.04).
How They Measured It
Gestational diabetes incidence, fasting glucose, insulin
To assess myo-inositol effect on insulin resistance in metabolic syndrome
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To assess myo-inositol effect on insulin resistance in metabolic syndrome
Dose
2 g twice daily
Participants
80 metabolic syndrome patients
Duration
6 months
Results
Myo-inositol significantly reduced insulin resistance, blood pressure, and triglycerides vs placebo.
How They Measured It
HOMA-IR, fasting insulin, postprandial glucose
To evaluate myo-inositol for insulin resistance, metabolic syndrome, PCOS, and gestational diabetes
Study Type
Randomised, controlled trial
Purpose
To evaluate myo-inositol for insulin resistance, metabolic syndrome, PCOS, and gestational diabetes
Dose
2-4 g/day
Participants
Multiple cohorts
Duration
Various
Results
Myo-inositol consistently improved insulin sensitivity across multiple metabolic conditions.
How They Measured It
Insulin sensitivity, HOMA-IR, glucose tolerance
Mental Health
To evaluate high-dose inositol supplementation for panic disorder
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate high-dose inositol supplementation for panic disorder
Dose
18 g/day myo-inositol
Participants
21 panic disorder patients
Duration
4 weeks
Results
Myo-inositol significantly reduced frequency and severity of panic attacks vs placebo (p<0.05).
How They Measured It
Panic attack frequency, Hamilton Anxiety Rating Scale
To evaluate inositol supplementation for depression
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To evaluate inositol supplementation for depression
Dose
12 g/day myo-inositol
Participants
28 depressed patients
Duration
4 weeks
Results
Myo-inositol supplementation significantly reduced HDRS scores vs placebo (p<0.05).
How They Measured It
Hamilton Depression Rating Scale (HDRS)
To assess myo-inositol effect on obsessive-compulsive disorder symptoms
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To assess myo-inositol effect on obsessive-compulsive disorder symptoms
Dose
18 g/day myo-inositol
Participants
13 OCD patients
Duration
6 weeks
Results
Myo-inositol significantly reduced Y-BOCS scores vs placebo in OCD patients.
How They Measured It
Yale-Brown OCD Scale (Y-BOCS)
To compare myo-inositol with fluvoxamine in the treatment of panic disorder
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To compare myo-inositol with fluvoxamine in the treatment of panic disorder
Dose
18 g/day myo-inositol
Participants
20 panic disorder patients
Duration
1 month per treatment (crossover)
Results
Myo-inositol reduced panic attacks as effectively as fluvoxamine with fewer side effects.
How They Measured It
Panic attack frequency, anxiety scales
To assess myo-inositol supplementation for anxiety in women with PCOS
Study Type
Randomised, double-blind, placebo-controlled
Purpose
To assess myo-inositol supplementation for anxiety in women with PCOS
Dose
4 g/day myo-inositol
Participants
46 PCOS women
Duration
12 weeks
Results
Myo-inositol significantly reduced anxiety and depression scores vs placebo in PCOS women.
How They Measured It
State-Trait Anxiety Inventory (STAI), depression scale
Frequently Asked Questions
Common questions about Myo-Inositol research
There are currently 13 peer-reviewed studies on Myo-Inositol (Myo-Inositol), involving 920 total participants. Research covers PCOS management, Insulin sensitivity, Mental health. The overall evidence strength is rated as Very Strong.
The evidence is currently rated as "Very Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (13 human studies), and reported outcomes.
Myo-Inositol has been researched for: PCOS management, Insulin sensitivity, Mental health. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 13 out of 13 studies are human trials. Human trials carry more weight in our evidence scoring system.
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