Blueberry Extract
Research reviewed: Up until 03/2026
Blueberry Extract (Vaccinium corymbosum) is a dietary supplement with 9 published peer-reviewed studies involving 419 participants, researched for Cognitive Function & Brain Health, Cardiovascular & Metabolic Health.
Evidence at a Glance
Strength is scored by study design, sample size, study type, and outcomes
Cognitive Function & Brain Health
ModerateCardiovascular & Metabolic Health
StrongResearch Visualised
Visual breakdown of the clinical data.
Study Quality Breakdown
What types of studies were conducted
Participants Per Study
Larger samples = more reliable results
Research Timeline
When the studies were published
All Studies
Detailed breakdown of each trial. Click to expand.
Cognitive Function & Brain Health
Wild blueberry polyphenols improve vascular function and cognitive performance in older adults
Study Type
Randomised double-blind placebo-controlled
Purpose
Wild blueberry polyphenols improve vascular function and cognitive performance in older adults
Dose
Daily WBB powder equivalent to 178g fresh weight
Participants
61 healthy older individuals
Duration
12 weeks
Results
Daily intake of wild blueberry powder improved vascular and cognitive function and decreased 24h ambulatory systolic BP. WBB polyphenols may reduce future CVD risk.
How They Measured It
Working memory, executive function, 24h ambulatory BP, FMD
Wild blueberry extract on acute cognitive and cardiovascular effects in older adults
Study Type
Multi-study randomised controlled investigation
Purpose
Wild blueberry extract on acute cognitive and cardiovascular effects in older adults
Dose
Wild blueberry extract (WBE) supplementation
Participants
Multiple studies, 40+ participants each
Duration
Acute and sub-acute
Results
WBE may have cardiovascular benefits and attenuate natural cognitive decline observed over the day. Positive effects particularly observed on circadian rhythm-driven postprandial periods.
How They Measured It
Cognitive battery, cardiovascular markers, circadian effects
Blueberry extract (V. corymbosum) anti-inflammatory effects
Study Type
Anti-inflammatory and antinociceptive study
Purpose
Blueberry extract (V. corymbosum) anti-inflammatory effects
Dose
Hydroalcoholic extract 100, 200, 300mg/kg
Participants
Animal models
Duration
Acute
Results
Demonstrated significant anti-inflammatory and antinociceptive effects at all doses. COX-inhibitory and antioxidant mechanisms identified.
How They Measured It
Anti-inflammatory and antinociceptive models; prostaglandin synthesis inhibition
Cardiovascular & Metabolic Health
Blueberry supplementation for cardiovascular risk factor reduction
Study Type
RCT
Purpose
Blueberry supplementation for cardiovascular risk factor reduction
Dose
Blueberry powder 22g/day
Participants
48 adults with metabolic syndrome
Duration
8 weeks
Results
Significantly reduced systolic blood pressure and improved endothelial function. HDL improved and LDL reduced. Anthocyanin-mediated NO pathway activation proposed.
How They Measured It
Blood pressure, endothelial function, lipid profile, glucose
Blueberry extract for insulin resistance and type 2 diabetes prevention
Study Type
Antidiabetic clinical study
Purpose
Blueberry extract for insulin resistance and type 2 diabetes prevention
Dose
Blueberry bioactive smoothie (44g freeze-dried blueberries)
Participants
32 obese, insulin-resistant volunteers
Duration
6 weeks
Results
Significant improvement in insulin sensitivity in obese volunteers. Improved insulin sensitivity correlated with adiponectin levels. Beneficial in insulin-resistant populations.
How They Measured It
HOMA-IR, fasting insulin, glucose tolerance, adiponectin
Blueberry supplementation for blood pressure reduction in hypertensive patients
Study Type
Hypertension RCT
Purpose
Blueberry supplementation for blood pressure reduction in hypertensive patients
Dose
22g/day blueberry powder
Participants
40 postmenopausal women with pre-hypertension
Duration
8 weeks
Results
Blueberry supplementation significantly reduced systolic blood pressure (-5.1 mmHg) compared with placebo. Endothelial function improved. Suggested for hypertension prevention.
How They Measured It
24h ABPM, FMD, arterial stiffness
Blueberry anthocyanins for systemic oxidative stress reduction
Study Type
Antioxidant study
Purpose
Blueberry anthocyanins for systemic oxidative stress reduction
Dose
600mg blueberry extract daily
Participants
50 healthy adults
Duration
8 weeks
Results
Significantly increased plasma antioxidant capacity and reduced oxidative stress biomarkers. Dose-dependent increases in plasma anthocyanin levels correlated with antioxidant effects.
How They Measured It
Plasma antioxidant capacity (ORAC), F2-isoprostanes, DNA oxidative damage
Blueberry powder for cholesterol and metabolic health in at-risk adults
Study Type
Cholesterol management study
Purpose
Blueberry powder for cholesterol and metabolic health in at-risk adults
Dose
25g freeze-dried blueberry powder daily
Participants
48 obese adults
Duration
8 weeks
Results
Blueberry powder significantly reduced total cholesterol and LDL-C while maintaining HDL. Improvements in inflammatory markers CRP and IL-6 also observed.
How They Measured It
Total cholesterol, LDL, HDL, triglycerides, apolipoprotein
Blueberry polyphenols on gut microbiome and metabolic health
Study Type
Gut microbiome and metabolic study
Purpose
Blueberry polyphenols on gut microbiome and metabolic health
Dose
22g freeze-dried blueberries daily
Participants
40 adults with abdominal obesity
Duration
4 weeks
Results
Blueberry supplementation significantly altered gut microbiome composition, increasing beneficial Bifidobacterium and Akkermansia species. SCFAs and metabolic markers improved.
How They Measured It
Gut microbiome composition, SCFAs, metabolic markers
Frequently Asked Questions
Common questions about Blueberry Extract research
There are currently 9 peer-reviewed studies on Blueberry Extract (Vaccinium corymbosum), involving 419 total participants. Research covers Cognitive function & memory, Cardiovascular protection, Antioxidant and 1 more areas. The overall evidence strength is rated as Strong.
The evidence is currently rated as "Strong Evidence". This rating is based on study design quality (randomisation, blinding, placebo controls), sample sizes, study types (9 human studies), and reported outcomes.
Blueberry Extract has been researched for: Cognitive function & memory, Cardiovascular protection, Antioxidant, Blood pressure management. Each area has its own body of evidence which you can explore in the study breakdowns above.
Yes, 9 out of 9 studies are human trials. Human trials carry more weight in our evidence scoring system.
Similar Supplements
Other supplements researched for similar health goals
