Recent Updates & Clinical Studies on Dietary Supplements

The information on this page relates to all topics covered in Supplement Science and is listed in chronological order with links to the specific page in which the supplement and clinical data is described in more detail.

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July 2017

Updated the Herbal Supplements page to include information on the compound, isoliquiritigenin, in the section discussing the health benefits of Licorice.

March 2017

Updated the Anti-Aging Supplements page to expand and enhance the functions of resveratrol, tyrosol, and curcumin, as well as added information to the section discussing Gynostemma pentaphylum extracts.

February 2017

Added a new page to the site covering anti-aging supplements Anti-Aging Supplements. Several supplements in this discussion have already been introduced and discussed such as quercitin, resveratrol, and curcumin.












February 2012

Discussion of recently discovered effects of resveratrol on reducing age-related metabolic dysfunction in the Resveratrol page.

Park, S-J, Ahmad, F, Philp, A, Baar, K, Williams, T, Luo, H, Ke, H, Rehmann, H, Taussig, R, Brown, AL, Kim, MK, Beaven, MA, Burgin, AB, Manganiello, V, and Chung, JH. 2012. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell 148(3):421-433

January 2012

Added a new section to the Antioxidants page discussing the activities of the flavonoid fisetin

Maher, P 2009. Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin. Genes Nutri. 4(4):297-307

June 2011

Recent news has reported that Boswellia serrata extracts (also known as Frankincense) may be useful in the treatment of rheumatoid arthritis. The extracts have been used for many years in traditional Ayurvedic medicine as an anti-inflammatory. New data evaluating the extracts indicates that the active ingredient in Boswellia extracts is β-boswellic acid.

Abdel-Tawab M, Werz O, and Schubert-Zsilavecz M 2011. Boswellia serrata: An Overall Assessment of In Vitro, Preclinical, Pharmacokinetic and Clinical Data. Clin. Pharmacokinet. 50(6):349-369

June 2011

Added a new page describing the usefulness of Spirulina supplements. Spirulina is a photosynthetic cyanobacteria that is a nearly complete food source. Its' protein complement contains all the amino acids required by humans for growth; it contains high amount of the omega-3 polyunsaturated fatty acids, EPA and DHA; it is rich in antioxidants; it contains most of the vitamins needed lacking only adequate amounts of vitamin B12.

May 2011

New research demonstrates that the polyphenol, epigallocatechin-3-O-gallate (EGCG), enhances insulin sensitivity. EGCG is the major polyphenol in green tea. EGCG has been shown to attenuate the negative effects of free fatty acids (FFAs) on insulin function via regulation of the activity of AMP-activated protein kinase (AMPK).

Li Y, Zhao S, Zhang W, Zhao P, He B, Wu N, and Han P 2011 Epigallocatechin-3-O-gallate (EGCG) attenuates FFAs-induced peripheral insulin resistance through AMPK pathway and insulin signaling pathway in vivo. Diabetes Res. Clin. Pract. Epub April 21, 2011.

January 2011

Added a section discussing the benefits of Morus alba (Mulberry) extracts in the Herbal Supplements page.

January 2011

A recently released study on the efficacy of the use of echinacea for the treatment of the common cold has found that there is no statistically significant difference in several parameters in comparison of placebo versus echinacea treated patients.

Barrett B, Brown R, Rakel D, Mundt M, Bone K, Barlow S, and Ewers T. 2010 Echinacea for treating the common cold: a randomized trial. Ann. Intern. Med. 153(12):769-777

November 2010

The potential for licorice extracts to be used as adjuncts in the treatment of type 2 diabetes was demonstrated when it was shown that compounds in the extracts can activate peroxisome proliferator-activated receptor-gamma (PPARγ). PPARγ is the target of the thiazolidinedione (TZD) class of type 2 diabetes drugs (for more information of the action of the TZDs see The Medical Biochemistry Page). Characterization of the alcohol extraction products from licorice found that at least 39 different phenolic compounds can identified. Of these, 12 were shown to bind to PPARγ. Oral administration of glycyrrhizic acid to high-fat diet-induced obesity rats resulted in a significant reduction in blood glucose levels and improved insulin sensitivity. In addition, the level of lipoprotein lipase, LPL (the blood vessel enzyme that removes fatty acids from circulating lipoproteins such as LDLs) was increased in numerous tissues such as skeletal muscle and adipose tissue but reduced in the liver. The significance of the increase in LPL activity in the various tissue was evidenced by a reduction in circulating free fatty acids, triacylglycerols, and LDL cholesterol. An additionally significant observation in this study was that the levels of HDL cholesterol (so-called "good cholesterol") increased suggesting there may be antiatherosclerotic properties of glycyrrhizic acid.

Eu CH, Lim WY, Ton SH, and bin Abdul Kadir K 2010. Glycyrrhizic acid improved lipoprotein lipase expression, insulin sensitivity, serum lipid and lipid deposition in high-fat diet-induced obese rats. Lipids Health Dis. 9:81

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Last modified: September 7, 2020